Toxicological and hygiene characterization of titanium dioxide nanoparticles introduced to the gastrointestinal tract of rats. Communication 1. Integral, biochemical and hematologic indices, small intestinal macromolecule absorption, DNA damage

Water suspensions of titanium dioxide nanoparticles were introduced intragastrically to growing male Wistar rats daily for 28 days. The data obtained revealed the presence of toxic risks related to said nanomaterials action and demonstrate the necessity of sanitary regulation of titanium dioxide nan...

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Bibliographic Details
Published in:	Voprosy pitaniia Vol. 79; no. 4; p. 21
Main Authors:	Raspolov, R V, Vernikov, V M, Shumakova, A A, Sentsova, T B, Trushina, E N, Mustafina, O K, Kravchenko, L V, Aksenov, I V, Selifanov, A V, Guseva, G V, Avren'eva, L I, Lashneva, N V, Ivanova, G N, Gmoshinskiĭ, I V, Bessonov, V V, Khotimchenko, S A, Tutel'ian, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2010
Subjects:	Administration, Oral Animals Blood Cell Count Body Weight - drug effects Crystallization DNA Damage Hemoglobins - analysis Intestinal Absorption - drug effects Intestine, Small - drug effects Intestine, Small - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Liver Function Tests Male Nanoparticles - toxicity Nanoparticles - ultrastructure Particle Size Rats Rats, Wistar Sulfhydryl Compounds - metabolism Titanium - chemistry Titanium - pharmacokinetics Titanium - toxicity Toxicity Tests, Chronic
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Summary:	Water suspensions of titanium dioxide nanoparticles were introduced intragastrically to growing male Wistar rats daily for 28 days. The data obtained revealed the presence of toxic risks related to said nanomaterials action and demonstrate the necessity of sanitary regulation of titanium dioxide nanoparticles used in food contact materials, cosmetics and other commodity.
ISSN:	0042-8833