Neurocysticercosis: a major aetiological factor of late‐onset epilepsy in Madagascar

To assess the impact of cysticercosis on public health in Madagascar, we compared patients < 15 years with late‐onset epilepsy to non‐epileptic controls in a matched case‐control study. The association between epilepsy and cysticercosis was studied by enzyme‐linked immunoelectrotransfer blot (EIT...

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Bibliographic Details
Published in:	Tropical medicine & international health Vol. 2; no. 8; pp. 741 - 746
Main Authors:	Andriantsimahavandy, A., Lesbordes, J. L., Rasoaharimalala, B., Peghini, M., Rabarijaona, L., Roux, J., Boisier, P.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-08-1997 Blackwell Science
Subjects:	Adolescent Adult Aged Animals Antibodies, Helminth - analysis Antibodies, Helminth - blood Antibodies, Helminth - cerebrospinal fluid Biological and medical sciences Case-Control Studies Cysticercosis Cysticercosis - complications Cysticercosis - epidemiology Diseases caused by cestodes enzyme‐linked immunoelectrotransfer blot Epilepsy - epidemiology Epilepsy - etiology Epilepsy - parasitology Female Helminthic diseases Humans Immunoblotting Infectious diseases late‐onset epilepsy Madagascar Madagascar - epidemiology Male Medical sciences Middle Aged Parasitic diseases population attributable risk percent Risk Seroepidemiologic Studies Taenia - immunology Tropical medicine Malagasy Republic Africa Madagascar Human Nervous system diseases Cysticercosis Epilepsy Parasitosis Helminthiasis Cestode disease Cerebral disorder Infection Etiology Central nervous system disease Risk factor Frequency Brain (vertebrata)
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Summary:	To assess the impact of cysticercosis on public health in Madagascar, we compared patients < 15 years with late‐onset epilepsy to non‐epileptic controls in a matched case‐control study. The association between epilepsy and cysticercosis was studied by enzyme‐linked immunoelectrotransfer blot (EITB) assay for antibodies specific to Taenia solium. The EITB assay was performed on 104 pairs of sera specimens and on 95 pairs of cerebrospinal fluid (CSF) specimens. Depending on whether we consider the results obtained from sera or from CSF, we obtain for the population attributable risk percent of cysticercosis in late‐onset epilepsy two slightly different estimates: 22.3% and 17.6%. Therefore cysticercosis is a major aetiological factor of late‐onset epilepsy in Madagascar. In the control group, the frequency of positive results, especially in CSF specimens (7.4%), confirms the existence of asymptomatic cases of neurocysticercosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1360-2276 1365-3156
DOI:	10.1046/j.1365-3156.1997.d01-379.x