Search Results - "Raso, Maria G"

Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling by SULLIVAN, James P, SPINOLA, Monica, HONORIO, Sofia, YANG XIE, SCAGLIONI, Pier P, DIMAIO, J. Michael, GAZDAR, Adi F, SHAY, Jerry W, WISTUBA, Ignacio I, MINNA, John D, DODGE, Michael, RASO, Maria G, BEHRENS, Carmen, BONING GAO, SCHUSTER, Katja, CHUNLI SHAO, LARSEN, Jill E, SULLIVAN, Laura A

“…Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-like properties. Immunohistochemical staining of a large panel of…”
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Immunohistochemical Expression of Estrogen and Progesterone Receptors Identifies a Subset of NSCLCs and Correlates with EGFR Mutation by RASO, Maria G, BEHRENS, Carmen, LEE, J. Jack, WISTUBA, Ignacio I, HERYNK, Matthew H, SUYU LIU, PRUDKIN, Ludmila, OZBURN, Natalie C, WOODS, Denise M, XIMING TANG, MEHRAN, Reza J, MORAN, Cesar

“…Purpose: To determine the frequency of estrogen receptor α and β and progesterone receptor protein immunohistochemical expression in a large set of non–small…”
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Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer by Padhye, Aparna, Konen, Jessica M, Rodriguez, B Leticia, Fradette, Jared J, Ochieng, Joshua K, Diao, Lixia, Wang, Jing, Lu, Wei, Solis, Luisa S, Batra, Harsh, Raso, Maria G, Peoples, Michael D, Minelli, Rosalba, Carugo, Alessandro, Bristow, Christopher A, Gibbons, Don L

“…Lack of sustained response to therapeutic agents in patients with KRAS-mutant lung cancer poses a major challenge and arises partly due to intratumor…”
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Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung by Tsuta, Koji, Raso, Maria G, Kalhor, Neda, Liu, Diane D, Wistuba, Ignacio I, Moran, Cesar A

“…Abstract Background Determining the differential diagnosis between typical (TCs) and atypical carcinoid tumors (ACs) is imperative, as the distinction between…”
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Sox10-positive sustentacular cells in neuroendocrine carcinoma of the lung by Tsuta, Koji, Raso, Maria G, Kalhor, Neda, Liu, Diane C, Wistuba, Ignacio I, Moran, Cesar A

“…Tsuta K, Raso M G, Kalhor N, Liu D C, Wistuba I I & Moran C A
(2011) Histopathology 58, 276–285
Sox10‐positive sustentacular cells in neuroendocrine carcinoma…”
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MYB expression by immunohistochemistry is highly specific and sensitive for detection of solid variant of adenoid cystic carcinoma of the breast among all triple‐negative breast cancers by Batra, Harsh, Bose, Priya S C, Ding, Yang, Dai, Alan, Chen, Hui, Albarracin, Constance T, Sun, Hongxia, Sahin, Aysegul A, Yang, Fei, Wistuba, Ignacio I, Raso, Maria G

“…Background Adenoid cystic carcinoma is a rare subtype of triple‐negative breast carcinoma. These low‐grade tumours, which are treated by simple mastectomy and…”
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PRECISE: Preoperative Radiation Therapy to Elicit Critical Immune Stimulating Effects – A Phase 2 Clinical Trial by Shaitelman, Simona F., Le-Petross, Huong, Raso, Maria G., Swanson, David M., Schalck, Aislyn P., Contreras, Alejandro, Yang, Fei, Muruganandham, Manickam, Zhao, George Z., Sawakuchi, Gabriel O., Kim, Leonard H., Batra, Harsh, Smith, Benjamin D., Stauder, Michael C., Woodward, Wendy A., Reddy, Jay P., Litton, Jennifer K., Thompson, Alastair, Bedrosian, Isabelle, Mittendorf, Elizabeth A.

“…Radiation therapy is an underinvestigated tool for priming the immune system in intact human breast cancers. We sought here to investigate if a preoperative…”
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Impad1 and Syt11 work in an epistatic pathway that regulates EMT-mediated vesicular trafficking to drive lung cancer invasion and metastasis by Bajaj, Rakhee, Rodriguez, B. Leticia, Russell, William K., Warner, Amanda N., Diao, Lixia, Wang, Jing, Raso, Maria G., Lu, Wei, Khan, Khaja, Solis, Luisa S., Batra, Harsh, Tang, Ximing, Fradette, Jared F., Kundu, Samrat T., Gibbons, Don L.

“…Lung cancer is a highly aggressive and metastatic disease responsible for approximately 25% of all cancer-related deaths in the United States. Using…”
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HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy by Perera, Samanthi A, Li, Danan, Shimamura, Takeshi, Raso, Maria G, Ji, Hongbin, Chen, Liang, Borgman, Christa L, Zaghlul, Sara, Brandstetter, Kathleyn A, Kubo, Shigeto, Takahashi, Masaya, Chirieac, Lucian R, Padera, Robert F, Bronson, Roderick T, Shapiro, Geoffrey I, Greulich, Heidi, Meyerson, Matthew, Guertler, Ulrich, Chesa, Pilar Garin, Solca, Flavio, Wistuba, Ignacio I, Wong, Kwok-Kin

“…Mutations in the HER2 kinase domain have been identified in human clinical lung cancer specimens. Here we demonstrate that inducible expression of the most…”
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Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non―Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy by FEI YANG, XIMING TANG, RASO, Maria G, GIRARD, Luc, COOMBES, Kevin, LEE, J. Jack, HERBST, Roy S, MINNA, John D, HEYMACH, John V, WISTUBA, Ignacio I, RIQUELME, Erick, BEHRENS, Carmen, NILSSON, Monique B, GIRI, Uma, VARELLA-GARCIA, Marileila, BYERS, Lauren A, LIN, Heather Y, JING WANG

“…VEGF receptor-2 (VEGFR-2 or kinase insert domain receptor; KDR) is a known endothelial target also expressed in NSCLC tumor cells. We investigated the…”
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Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC by Guo, Chengcheng, Shao, Ruping, Correa, Arlene M, Behrens, Carmen, Johnson, Faye M, Raso, Maria G, Prudkin, Ludmila, Solis, Luisa M, Nunez, Maria I, Fang, Bingliang, Roth, Jack A, Wistuba, Ignacio I, Swisher, Stephen G, Lin, Tongyu, Pataer, Apar

“…RNA-dependent protein kinase (PKR) is an independent prognostic variable in patients with non-small-cell lung cancer (NSCLC). In the current study, we…”
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Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion by Moussalli, Micheline J, Wu, Yuanqing, Zuo, Xiangsheng, Yang, Xiu L, Wistuba, Ignacio Ivan, Raso, Maria G, Morris, Jeffrey S, Bowser, Jessica L, Minna, John D, Lotan, Reuben, Shureiqi, Imad

“…Loss of terminal cell differentiation promotes tumorigenesis. 15-Lipoxygenase-1 (15-LOX-1) contributes to terminal cell differentiation in normal cells. The…”
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Analysis of tumor- and circulating-free DNA methylation to identify clinically relevant small cell lung cancer subtypes by Heeke, Simon, Gay, Carl Michael, Estecio, Marcos Roberto, Tran, Hai T., Morris, Benjamin B., Zhang, Bingnan, Tang, XiMing, Raso, Maria G, Rocha, Pedro, Arriola, Edurne, Hofman, Paul, Kopparapu, Prasad, Lovly, Christine M., Concannon, Kyle, Xi, Yuanxin, Diao, Lixia, Wang, Qi, Wang, Jing, Byers, Lauren Averett, Heymach, John

“…8577 Background: Small-cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, defined by the predominant expression…”
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Abstract P058: Anti-tumor activity of ATR inhibitor BAY 1895344 in patient-derived xenograft (PDX) models with DNA damage response (DDR) pathway alterations by Pico, Christian X. Cruz, Li, Dali, Lanier, Christopher D., Evans, Kurt, Raso, Maria G., DiPeri, Timothy, Rizvi, Yasmeen, Ha, Min Jin, Chen, Huiqin, Zhao, Ming, Akcakanat, Argun, Zheng, Xiaofeng, Toruner, Gokce, Yuca, Erkan, Scott, Stephen, Wengner, Antje M., Yap, Timothy A., Meric-Bernstam, Funda

“…Abstract Introduction: The ATR (ataxia-telangiectasia and Rad3 related protein) kinase inhibitor BAY 1895344 is currently in clinical development for the…”
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Abstract 6180: Antitumor activity of the ATR inhibitor Elimusertib in patient-derived xenograft models with DNA damage response pathway alterations by Varadarajan, Kaushik, Pico, Christian X., Evans, Kurt, Raso, Maria G., Rizvi, Yasmeen, Zheng, Xiaofeng, Diperi, Timothy P., Wang, Bailiang, Scott, Stephen, Zhao, Ming, Akcakanat, Argun, Wengner, Antje M., Yap, Timothy A., Meric-Bernstam, Funda

“…Abstract Introduction: The ataxia telangiectasia and RAD3-related (ATR) kinase is a key component of the DNA damage response (DDR) and functions in conjunction…”
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Abstract 515: Single-cell transcriptomic analysis of HR+/HER2- breast cancer identifies gene signatures that predict outcomes of luminal A and B subtypes by Mastoraki, Sofia, Lin, Jerome, Rao, Xiayu, Liu, Sophie R., Batra, Harsh, Raso, Maria G., Cuentas, Edwin R. Parra, Raghavendra, Akshara S., Rasaputra, Komal S., Yi, Min, Wang, Jing, Sahin, Aysegul, Tripathy, Debasish, Hunt, Kelly K., Navin, Nicholas E., Keyomarsi, Khandan

“…Abstract Introduction: Patients with luminal A and B early-stage ER+/HER2- breast cancer (BrCa) are uniformly treated with adjuvant endocrine therapy (ET)…”
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Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response by Zhao, Mei, Wang, Tianxiao, Gleber-Netto, Frederico O., Chen, Zhen, McGrail, Daniel J., Gomez, Javier A., Ju, Wutong, Gadhikar, Mayur A., Ma, Wencai, Shen, Li, Tang, Ximing, Pathak, Sen, Raso, Maria G., Burks, Jared, Lin, Shiaw-Yih, Wang, Jing, Multani, Asha S., Pickering, Curtis R., Chen, Junjie, Myers, Jeffrey N., Zhou, Ge

“…Abstract TP53 mutations are the most common cancer driver mutations among all cancers. Although some TP53 mutations lead to a loss of function of wild-type…”
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Use of a proliferation-based mRNA signature to predict outcome in early-stage non-small cell lung adenocarcinoma by Behrens, Carmen, Lombardi, Francesca, Wagner, Susanne, Fujimoto, Junya, Raso, Maria G, Spaggiari, Lorenzo, Galetta, Domenico, Huges, Elisha, Reid, Julia E., Sangale, Zaina, Swisher, Stephen, Kalhor, Neda, Moran, Cesar, Gutin, Alexander, Lanchbury, Jerry S., Kim, Edward S., Barberis, Massimo, Wistuba, Ignacio I.

“…Abstract only 7023 Background: Adjuvant treatment of patients with early-stage lung adenocarcinoma is based on post-surgical pathological staging and patient…”
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Abstract 1417: Molecular abnormalities associated to the progression of lung adenocarcinomas with BAC features from non-invasive to invasive patterns by Solis, Luisa M., Raso, Maria G., Fujimoto, Junya, Behrens, Carmen, Woods, Denise M., Mendoza, Gabriela, Kalhor, Neda, Moran, Cesar A., Wistuba, Ignacio I.

“…Abstract Background: Most invasive lung adenocarcinomas (LAC) consist of mixed histological growth patterns including a non-invasive component referred as…”
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Abstract 787: Differences in protein expression patterns in lung adenocarcinomas arising in never versus ever smokers by Behrens, Carmen, Lin, Heather, Nunez, Maria, Yuan, Ping, Solis, Luisa, Raso, Maria G., Prudkin, Ludmila, Sun, Menghong, Li, Xiaoling, Tang, Ximing, Roth, Jack A., Minna, John D., Stewart, David J., Hong, Waun K., Lee, J. Jack, Wistuba, Ignacio I.

“…Abstract Background. Approximately 25% of lung cancer cases worldwide, mostly adenocarcinomas, are not attributable to tobacco use. Despite that some striking…”
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