Search Results - "Raslova, H."

Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia by Antony-Debré, I, Duployez, N, Bucci, M, Geffroy, S, Micol, J-B, Renneville, A, Boissel, N, Dhédin, N, Réa, D, Nelken, B, Berthon, C, Leblanc, T, Mozziconacci, M-J, Favier, R, Heller, P G, Abdel-Wahab, O, Raslova, H, Latger-Cannard, V, Preudhomme, C

Get full text

The cell division control protein 42–Src family kinase–neural Wiskott–Aldrich syndrome protein pathway regulates human proplatelet formation by Palazzo, A., Bluteau, O., Messaoudi, K., Marangoni, F., Chang, Y., Souquere, S., Pierron, G., Lapierre, V., Zheng, Y., Vainchenker, W., Raslova, H., Debili, N.

“…Essentials The role of the cytoskeleton during megakaryocyte differentiation was examined. Human megakaryocytes are derived from in vitro cultured CD34+ cells…”
Get full text

Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development by Donada, A., Basso-Valentina, F., Arkoun, B., Monte-Mor, B., Plo, I., Raslova, H.

“…•iPSC and hematopoietic differentiation.•iPSC: a powerful tool for inherited and acquired hematological disease modeling.•iPSC: a robust model for drug…”
Get full text

Developmental changes in human megakaryopoiesis by Bluteau, O., Langlois, T., Rivera‐Munoz, P., Favale, F., Rameau, P., Meurice, G., Dessen, P., Solary, E., Raslova, H., Mercher, T., Debili, N., Vainchenker, W.

“…Summary Background The molecular bases of the cellular changes that occur during human megakaryocyte (MK) ontogeny remain unknown, and may be important for…”
Get full text

The abnormal proplatelet formation in MYH9‐related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition by Chen, Y., Boukour, S., Milloud, R., Favier, R., Saposnik, B., Schlegel, N., Nurden, A., Raslova, H., Vainchenker, W., Balland, M., Nurden, P., Debili, N.

“…Summary Background Mutations in the MYH9 gene cause autosomal dominant MYH9‐related diseases (MYH9‐RD) that associate macrothrombocytopenia with various other…”
Get full text

Regulation of megakaryocyte maturation and platelet formation by BLUTEAU, D., LORDIER, L., DI STEFANO, A., CHANG, Y., RASLOVA, H., DEBILI, N., VAINCHENKER, W.

“…Each day in every human, approximately 1 × 1011 platelets are produced by the cytoplasmic fragmentation of megakaryocytes (MK), their marrow precursor cells…”
Get full text

Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets by Glembotsky, A. C., Bluteau, D., Espasandin, Y. R., Goette, N. P., Marta, R. F., Marin Oyarzun, C. P., Korin, L., Lev, P. R., Laguens, R. P., Molinas, F. C., Raslova, H., Heller, P. G.

“…Summary Background Familial platelet disorder with a predisposition to acute myelogenous leukemia (FPD/AML) is an inherited platelet disorder caused by a…”
Get full text

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms by Ali, A, Bluteau, O, Messaoudi, K, Palazzo, A, Boukour, S, Lordier, L, Lecluse, Y, Rameau, P, Kraus-Berthier, L, Jacquet-Bescond, A, Lelièvre, H, Depil, S, Dessen, P, Solary, E, Raslova, H, Vainchenker, W, Plo, I, Debili, N

“…Abexinostat is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound…”
Get full text

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro by Moniz, H, Gastou, M, Leblanc, T, Hurtaud, C, Crétien, A, Lécluse, Y, Raslova, H, Larghero, J, Croisille, L, Faubladier, M, Bluteau, O, Lordier, L, Tchernia, G, Vainchenker, W, Mohandas, N, Da Costa, L

“…Diamond-Blackfan anemia (DBA) is caused by aberrant ribosomal biogenesis due to ribosomal protein (RP) gene mutations. To develop mechanistic understanding of…”
Get full text

The serum response factor (SRF) megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development by Ragu, C, Boukour, S, Elain, G, Wagner-Ballon, O, Raslova, H, Debili, N, Olson, E N, Daegelen, D, Vainchenker, W, Bernard, O A, Penard-Lacronique, V

Get full text

COOPERAÇÃO DAS MUTAÇÕES CALR E TP53 NA TRANSFORMAÇÃO LEUCÊMICA DAS NEOPLASIAS MIELOPROLIFERATIVAS by S Benedito, P Sabbo, B Arkoun, M Bonamino, CM Oiarzun, H Raslova, I Antony-Debré, I Plo, B Monte-Mór

“…Introdução: As Neoplasias Mieloproliferativas (NMPs) são caracterizadas por mutações driver nos genes JAK2, CALR ou MPL que levam à ativação constitutiva do…”
Get full text

p210 reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription by Buet, D, Raslova, H, Geay, J-F, Jarrier, P, Lazar, V, Turhan, A, Morlé, F, Vainchenker, W, Louache, F

“…The BCR-ABL oncoprotein exhibits deregulated protein tyrosine kinase activity and is implicated in the pathogenesis of Philadelphia chromosome (Ph)-positive…”
Get full text

Occurrence of human papillomavirus 16 and 18 in smears from the two cervix regions of onco-gynecological patients in Slovakia by Kúdelová, M, Krivos, V, Raslová, H, Valovicová, M, Belvoncíková, P, Matis, J

“…We evaluated the relevance of tests for Human papillomavirus 16 and 18 (HPV-16, HPV-18) in two cervix regions (exocervical and endocervical) separately. The…”
Get more information

A murine gammaherpesvirus by Mistríková, J, Raslová, H, Mrmusová, M, Kúdelová, M

“…In 1976, within a project on isolation of herpesviruses from small rodents in former Czechoslovakia, the mouse herpesvirus strain 68 (MHV-68) was isolated…”
Get more information

Immunophenotypic study of atypical lymphocytes. Generated in peripheral blood and spleen of nude mice After MHV-72 infection by Raslova, H, Mistrikova, J, Kudelova, M, Mishal, Z, Sarasin, A, Blangy, D, Berebbi, M

“…Inbred athymic nude mice (BALB/c) were injected subcutaneously with the wild-type murine gammaherpesvirus 72 (MHV-72), which has been shown to induce the…”
Get more information

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies by Saliba, Joseph, Saint-Martin, Cécile, Di Stefano, Antonio, Lenglet, Gaëlle, Marty, Caroline, Keren, Boris, Pasquier, Florence, Valle, Véronique Della, Secardin, Lise, Leroy, Gwendoline, Mahfoudhi, Emna, Grosjean, Sarah, Droin, Nathalie, Diop, M'boyba, Dessen, Philippe, Charrier, Sabine, Palazzo, Alberta, Merlevede, Jane, Meniane, Jean-Côme, Delaunay-Darivon, Christine, Fuseau, Pascal, Isnard, Françoise, Casadevall, Nicole, Solary, Eric, Debili, Najet, Bernard, Olivier A, Raslova, Hana, Najman, Albert, Vainchenker, William, Bellanné-Chantelot, Christine, Plo, Isabelle

“…Isabelle Plo, Christine Bellanné-Chantelot, William Vainchenker and colleagues report a 700-kb germline duplication including the ATG2B and GSKIP genes in four…”
Get full text

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera by Ugo, Valérie, Lacout, Catherine, Villeval, Jean Luc, Le Couédic, Jean-Pierre, James, Chloé, Vainchenker, William, Berger, Roland, Raslova, Hana, Casadevall, Nicole, Bennaceur-Griscelli, Annelise, Delhommeau, François, Garçon, Loïc, Staerk, Judith, Constantinescu, Stefan N

“…Myeloproliferative disorders are clonal haematopoietic stem cell malignancies characterized by independency or hypersensitivity of haematopoietic progenitors…”
Get full text

Eltrombopag, a potent stimulator of megakaryopoiesis by Raslova, Hana, Vainchenker, William, Plo, Isabelle

Get full text

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy by CASTEDO, Maria, PERFETTINI, Jean-Luc, VAINCHENKER, William, KROEMER, Guido, ROUMIER, Thomas, VALENT, Alexander, RASLOVA, Hana, YAKUSHIJIN, Kenichi, HORNE, David, FEUNTEUN, Jean, LENOIR, Gilbert, MEDEMA, René

“…A conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe when the DNA structure checkpoints are inactivated, for instance when the…”
Get full text

Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation by Raslova, Hana, Baccini, Véronique, Loussaief, Lamya, Comba, Béatrice, Larghero, Jérôme, Debili, Najet, Vainchenker, William

“…A major determinant in platelet production is the megakaryocyte (MK) size that is regulated both by ploidization and the increase in cytoplasmic volume at the…”
Get full text