Search Results - "Rask, Philip J"
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SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers
Published in The Journal of clinical investigation (01-06-2022)“…Poly(ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in the treatment of ovarian and breast cancers. PARP inhibitors are…”
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Journal Article -
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A Novel Salt Inducible Kinase 2 Inhibitor, ARN-3261, Sensitizes Ovarian Cancer Cell Lines and Xenografts to Carboplatin
Published in Cancers (25-01-2021)“…Salt-induced kinase 2 (SIK2) is a serine-threonine kinase that regulates centrosome splitting, activation of PI3 kinase and phosphorylation of class IIa HDACs,…”
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Journal Article -
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DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
Published in Cancers (18-04-2019)“…Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role…”
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Journal Article