Search Results - "Rasheed, Suhail Ahmed Kabeer"

Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells by Schwab, Annemarie, Siddiqui, Aarif, Vazakidou, Maria Eleni, Napoli, Francesca, Böttcher, Martin, Menchicchi, Bianca, Raza, Umar, Saatci, Özge, Krebs, Angela M, Ferrazzi, Fulvia, Rapa, Ida, Dettmer-Wilde, Katja, Waldner, Maximilian J, Ekici, Arif B, Rasheed, Suhail Ahmed Kabeer, Mougiakakos, Dimitrios, Oefner, Peter J, Sahin, Ozgur, Volante, Marco, Greten, Florian R, Brabletz, Thomas, Ceppi, Paolo

“…Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene…”
Get full text

The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors by Rasheed, Suhail Ahmed Kabeer, Subramanyan, Lalitha Vaishnavi, Lim, Wei Kiang, Udayappan, Udhaya Kumari, Wang, Mei, Casey, Patrick J.

“…G12 proteins comprise a subfamily of G-alpha subunits of heterotrimeric GTP-binding proteins (G proteins) that link specific cell surface G protein-coupled…”
Get full text

A mechanistic study on the metastasis inducing function of FUS‐CHOP fusion protein in liposarcoma by Patil, Nitin, Ahmed Kabeer Rasheed, Suhail, Abba, Mohammed, Hendrik Leupold, Jörg, Schwarzbach, Matthias, Allgayer, Heike

“…The FUS‐CHOP fusion protein has been found to be instrumental for specific oncogenic processes in liposarcoma, but its ability to induce metastasis and the…”
Get full text

First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases by Rasheed, Suhail Ahmed Kabeer, Efferth, Thomas, Asangani, Irfan Ahmed, Allgayer, Heike

“…Despite progress in treatment, progressive non–small cell lung cancer (NSCLC) still limits survival dramatically, and novel therapeutic compounds are needed…”
Get full text

GNA13 suppresses proliferation of ER+ breast cancer cells via ERα dependent upregulation of the MYC oncogene by Subramanyan, Lalitha Vaishnavi, Rasheed, Suhail Ahmed Kabeer, Wang, Lijin, Ghosh, Sujoy, Ong, Michelle Shi Ning, Lakshmanan, Manikandan, Wang, Mei, Casey, Patrick J

“…GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is known to…”
Get full text

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers by Siddiqui, Aarif, Gollavilli, Paradesi Naidu, Schwab, Annemarie, Vazakidou, Maria Eleni, Ersan, Pelin G., Ramakrishnan, Mallika, Pluim, Dick, Coggins, Si’Ana, Saatci, Ozge, Annaratone, Laura, HM Schellens, Jan, Kim, Baek, Asangani, Irfan Ahmed, Rasheed, Suhail Ahmed Kabeer, Marchiò, Caterina, Sahin, Ozgur, Ceppi, Paolo

“…Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor…”
Get full text

MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells by Rasheed, Suhail Ahmed Kabeer, Teo, Cui Rong, Beillard, Emmanuel Jean, Voorhoeve, P Mathijs, Zhou, Wei, Ghosh, Sujoy, Casey, Patrick J

“…Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). Our recent study…”
Get full text

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers by Rasheed, Suhail Ahmed Kabeer, Leong, Hui Sun, Lakshmanan, Manikandan, Raju, Anandhkumar, Dadlani, Dhivya, Chong, Fui-Teen, Shannon, Nicholas B, Rajarethinam, Ravisankar, Skanthakumar, Thakshayeni, Tan, Ern Yu, Hwang, Jacqueline Siok Gek, Lim, Kok Hing, Tan, Daniel Shao-Weng, Ceppi, Paolo, Wang, Mei, Tergaonkar, Vinay, Casey, Patrick J., Iyer, N. Gopalakrishna

“…Treatment failure in solid tumors occurs due to the survival of specific subpopulations of cells that possess tumor-initiating (TIC) phenotypes. Studies have…”
Get full text

GNA13 suppresses proliferation of ER+ breast cancer cells via ER[alpha] dependent upregulation of the MYC oncogene by Subramanyan, Lalitha Vaishnavi, Rasheed, Suhail Ahmed Kabeer, Wang, Lijin, Ghosh, Sujoy, Ong, Michelle Shi Ning, Lakshmanan, Manikandan, Wang, Mei, Casey, Patrick J

“…GNA13 (G[alpha]13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is…”
Get full text

MicroRNA-182 and MicroRNA-200a Control G-protein Subunit α-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells by Rasheed, Suhail Ahmed Kabeer, Teo, Cui Rong, Beillard, Emmanuel Jean, Voorhoeve, P.Mathijs, Casey, Patrick J.

“…G protein-coupled receptors (GPCRs) and their ligands have been implicated in progression and metastasis of several cancers. GPCRs signal through…”
Get full text

Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB by Lim, Wei Kiang, Chai, Xiaoran, Ghosh, Sujoy, Ray, Debleena, Wang, Mei, Rasheed, Suhail Ahmed Kabeer, Casey, Patrick J.

“…GNA13, the α subunit of a heterotrimeric G protein, mediates signaling through G-protein–coupled receptors (GPCRs). GNA13 is up-regulated in many solid tumors,…”
Get full text

The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins by Teo, Cui Rong, Casey, Patrick J, Rasheed, Suhail Ahmed Kabeer

“…Gα13 (encoded by GNA13 gene) is the alpha subunit of a heterotrimeric G-protein that mediates signaling through specific G-protein-coupled receptors (GPCRs)…”
Get full text

Abstract 2660: HMBD-501 - a novel Fc engineered, exatecan-based next generation HER3 targeting antibody drug conjugate shows robust efficacy and tolerability in pre-clinical solid tumor models by Rasheed, Suhail Ahmed Kabeer, Thakkar, Dipti, Paliwal, Shalini, Chin, Wen Jie, Bansal, Akshaya, Ayers, Ben, ng, Che Theng, Hanson, Brendon, Ingram, Piers, Boyd-Kirkup, Jerome

“…Abstract HER3 is a member of the epidermal growth factor receptor (ERBB) family of tyrosine kinase receptors overexpressed in a broad range of tumors and is…”
Get full text

Abstract 3887: GNA13 is a theranostic target that drives drug resistance and cancer stem-like phenotypes in solid tumors by Rasheed, Suhail Ahmed Kabeer, Leong, Hui Sun, Lakshmanan, Manikandan, Raju, Anandhkumar, Dadlani, Dhivya, Chong, Fui-Teen, Rajarethinam, Ravisankar, Skanthakumar, Thakshayeni, Tan, Ern Yu, Hwang, Jacqueline Siok Gek, Lim, Kok Hing, Tan, Daniel Shao-Weng, Ceppi, Paolo, Wang, Mei, Tergaonkar, Vinay, Casey, Patrick J., Iyer, N. Gopalakrishna

“…Abstract Treatment failure in solid tumors occurs due to the survival of specific subpopulations of cells that possess stem cell-like (CSC) phenotypes. Studies…”
Get full text

Gα-13 induces C X C motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB by Lim, Wei Kiang, Chai, Xiaoran, Ghosh, Sujoy, Ray, Debleena, Wang, Mei, Rasheed, Suhail Ahmed Kabeer, Casey, Patrick J

“…GNA13, the α subunit of a heterotrimeric G protein, mediates signaling through G-protein-coupled receptors (GPCRs). GNA13 is up-regulated in many solid tumors,…”
Get full text

Abstract LB-278: MicroRNA control of GNA13 expression and cancer cell invasion by Rasheed, Suhail Ahmed Kabeer, Teo, Cui Rong, Beillard, Emmanuel, Voorhoeve, P. Mathijs, Casey, Patrick

“…Abstract Heterotrimeric guanine nucleotide binding proteins (G proteins) transmit a variety of extracellular signals from cell surface G protein-coupled…”
Get full text

Abstract LB-358: A mechanistic study on the metastasis inducing function of FUS-CHOP fusion protein in liposarcoma by Patil, Nitin, Rasheed, Kabeer Suhail Ahmed, Leupold, Jörg Hendrik, Schwarzbach, Matthias, Allgayer, Heike

“…Abstract Myxoid liposarcoma exhibits a stable reciprocal translocation, leading to expression of FUS-CHOP chimeric oncogenic protein. Furthermore, studies have…”
Get full text

Abstract LB-272: First evidence that FUS-CHOP leads to increased invasion and migration via MMPs in liposarcoma by Patil, Nitin, Rasheed, Suhail Ahmed Kabeer, Laufs, Stephanie, Schwarzbach, Matthias, Allgayer, Heike

“…Abstract A unique feature of human soft tissue liposarcoma is that it exhibits a characteristic and stable translocation (12;16)(113;p11), resulting in (a)…”
Get full text

Abstract 1466: Smad 7 induces invasion, migration and in vivo metastasis in Non Small Cell Lung Cancer by Udainiya, Savita, Rasheed, Suhail Ahmed Kabeer, Meyer, Christoph, Leupold, Jörg Hendrick, Ceppi, Paolo, Dooley, Steven, Karunagaran, Devarajan, Papotti, Mauro, Allgayer, Heike

“…Abstract Lung cancer is one of the most common cancers, 75% of the cases being non small cell lung cancer (NSCLC). Despite recent advances in the cancer…”
Get full text