Formulation, characterization of glucosamine loaded transfersomes and in vivo evaluation using papain induced arthritis model

Formulation, characterization of glucosamine loaded transfersomes and in vivo evaluation using papain induced arthritis model

The aim of current study was to develop the transdermal transfersomes of glucosamine for better drug delivery. Stretch ability and plasticity of transfersomes membranes mitigate the risk of vesicle rupture in the skin and allows the drug carrying transfersome to pass through the epidermis following...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; pp. 19813 - 13
Main Authors: Rasheed, Muhammad Shahzad, Ansari, Sameen Fatima, Shahzadi, Iram
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 17-11-2022
Nature Publishing Group
Nature Portfolio
Subjects:
639/925
692/308
692/699
Administration, Cutaneous
Animals
Arthritis
Drug delivery
Epidermis
Glucosamine
Humanities and Social Sciences
multidisciplinary
Oral administration
Osteoarthritis
Papain
Rabbits
Radiology
Risk reduction
Science
Science (multidisciplinary)
Shelf life
Skin
Skin Absorption
Thin films
Zeta potential
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Summary:The aim of current study was to develop the transdermal transfersomes of glucosamine for better drug delivery. Stretch ability and plasticity of transfersomes membranes mitigate the risk of vesicle rupture in the skin and allows the drug carrying transfersome to pass through the epidermis following the natural water gradient. Transdermal delivery of Glucosamine has an advantage over oral route, having greater local concentration and fewer systemic effects. Thin Film Rotary method was use to prepare transfersomes, and characterization was carried out physio-chemically using electron microscopic studies, zeta potential evaluation, entrapment efficiency studies. To add on in the stability, development of a secondary topical vehicle using Carbopol 940 was carried out to enhance the shelf life of transfersomes. Furthermore, in vivo studies on rabbits were also carried out using the papain induced arthritis model to support the effectiveness of treatment. The radiology studies of knee joint of rabbits proved the effectiveness of glucosamine loaded transfersomes in healing the osteoarthritis with the blood plasma analysis remain unaltered. In vitro characterization showed the successful development of nano-deformable entities with good entrapment efficiency but with little stability, therefore modified into a gel. In a nut shell this modified new dosage from can be best alternative to other conventional options that owe lot of demerits.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-23103-1