Search Results - "Rashbrook, Victoria S."

Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion by Brash, James T., Bolton, Rebecca L., Rashbrook, Victoria S., Denti, Laura, Kubota, Yoshiaki, Ruhrberg, Christiana

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Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia by Rashbrook, Victoria S, Denti, Laura, Ruhrberg, Christiana

“…Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown…”
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PHACTR1 modulates vascular compliance but not endothelial function: a translational study by Wood, Alice, Antonopoulos, Alexios, Chuaiphichai, Surawee, Kyriakou, Theodosios, Diaz, Rebeca, Al Hussaini, Abtehale, Marsh, Anna-Marie, Sian, Manjit, Meisuria, Mitul, McCann, Gerry, Rashbrook, Victoria S, Drydale, Edward, Draycott, Sally, Polkinghorne, Murray David, Akoumianakis, Ioannis, Antoniades, Charalambos, Watkins, Hugh, Channon, Keith M, Adlam, David, Douglas, Gillian

“…The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele in myocardial infarction and multiple other…”
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Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression by Douglas, Gillian, Hale, Ashley B, Patel, Jyoti, Chuaiphichai, Surawee, Al Haj Zen, Ayman, Rashbrook, Victoria S, Trelfa, Lucy, Crabtree, Mark J, McNeill, Eileen, Channon, Keith M

“…Abstract Aims GTP cyclohydrolase I catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for…”
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Mutagenesis on a complex mouse genetic background by site-specific nucleases by Davies, Benjamin, Trelfa, Lucy, Rashbrook, Victoria S, Drydale, Edward, Martin, Rachel, Bai, Boyan, Golebka, Jedrzej, Biggs, Daniel Stephen, Channon, Keith M, Bhattacharya, Shoumo, Douglas, Gillian

“…Mouse models with complex genetic backgrounds are increasingly used in preclinical research to accurately model human disease and to enable temporal and…”
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A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction by Douglas, Gillian, Mehta, Vedanta, Al Haj Zen, Ayman, Akoumianakis, Ioannis, Goel, Anuj, Rashbrook, Victoria S, Trelfa, Lucy, Donovan, Lucy, Drydale, Edward, Chuaiphichai, Surawee, Antoniades, Charalambos, Watkins, Hugh, Kyriakou, Theodosios, Tzima, Ellie, Channon, Keith M

“…Abstract Aims Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on…”
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Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm by Chuaiphichai, Surawee, Rashbrook, Victoria S., Hale, Ashley B., Trelfa, Lucy, Patel, Jyoti, McNeill, Eileen, Lygate, Craig A., Channon, Keith M., Douglas, Gillian

“…GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function…”
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P7 LOSS OF KIAA1462, A CORONARY ARTERY DISEASE ASSOCIATED GENE, DECREASES ATHEROSCLEROSIS by Douglas, Gillian, Kyriakou, Theodosios, Rashbrook, Victoria S, Drydale, Edward, Al Haj Zen, Ayman, Trelfa, Lucy, Mehta, Vedanta, Tzima, Ellie, Watkins, Hugh, Channon, Keith M

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Abstract 442: Loss of Kiaa1462 , a Coronary Artery Disease Associated Gene, Decreases Atherosclerosis by Douglas, Gillian, Kyriakou, Theodosios, Rashbrook, Victoria S, Al Haj Zen, Ayman, Trelfa, Lucy, Mehta, Vedanta, Tzima, Ellie, Watkins, Hugh, Channon, Keith

“…Abstract only Introduction: KIAA1462 is the only coding gene in a chromosome 10 genomic locus consistently associated with Coronary Artery Disease (CAD) in…”
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