Reduced sensory gating of the P1 potential in rape victims and combat veterans with posttraumatic stress disorder

The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age‐matched female control group; and in male combat veterans with PTSD and compared to three groups of age‐matched male control subjects. Sensory gating of the...

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Bibliographic Details
Published in:	Depression and anxiety Vol. 9; no. 3; pp. 122 - 130
Main Authors:	Skinner, R.D., Rasco, L.M., Fitzgerald, J., Karson, C.N., Matthew, M., Williams, D.K., Garcia-Rill, E.
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 1999
Subjects:	Acoustic Stimulation Adult Alcoholism - physiopathology Analysis of Variance Arousal - physiology auditory evoked potentials Auditory Pathways - physiopathology Case-Control Studies Combat Disorders - physiopathology combat veterans Crime Victims Evoked Potentials, Auditory, Brain Stem - physiology Female Habituation, Psychophysiologic - physiology Humans locus coeruleus Male Middle Aged Neural Inhibition - physiology P1/P50 potential pedunculopontine nucleus posttraumatic stress disorder Rape rape victims Reticular Formation - physiopathology Stress Disorders, Post-Traumatic - physiopathology Time Factors
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Summary:	The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age‐matched female control group; and in male combat veterans with PTSD and compared to three groups of age‐matched male control subjects. Sensory gating of the P1 potential was determined using a paired click stimulus paradigm in which the stimuli were presented at 250, 500 and 1000 msec interstimulus intervals (ISI). Results showed that sensory gating of the P1 potential was significantly decreased at the 250 msec ISI, and that there was a numerical, but not a statistically significant, decrease in sensory gating at the other intervals tested in both male and female PTSD subjects compared to all control groups. Since the P1 potential may be generated, at least in part, by the reticular activating system, dysregulation of sensory processing by elements of this system may be present in PTSD. Depression and Anxiety 9:122–130, 1999.© 1999 Wiley‐Liss, Inc.
Bibliography:	ark:/67375/WNG-B9DZG6MT-7 ArticleID:DA4 USPHS - No. NS20246 istex:57F77602DB372C73F5123D68CB700D09512AF813 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1091-4269 1520-6394
DOI:	10.1002/(SICI)1520-6394(1999)9:3<122::AID-DA4>3.0.CO;2-M