Search Results - "Raschko, J W"

Oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough pain in cancer patients: a controlled dose titration study by Portenoy, R K, Payne, R, Coluzzi, P, Raschko, J W, Lyss, A, Busch, M A, Frigerio, V, Ingham, J, Loseth, D B, Nordbrock, E, Rhiner, M

“…Oral transmucosal fentanyl citrate (OTFC) is a novel opioid formulation in which the potent synthetic mu-agonist fentanyl is embedded in a sweetened matrix…”
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High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma: toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome by SOMLO, G, DOROSHOW, J. H, RASCHKO, J. W, SHIBATA, S. I, TETEF, M. L, YEN, Y, KOGUT, N, SCHRIBER, J, ALVARNAS, J, SYNOLD, T, LONGMATE, J, REARDON, D, CHOW, W, FORMAN, S. J, LEONG, L. A, MARGOLIN, K. A, MORGAN, R. J

“…We assessed the feasibility and pharmacokinetics of high-dose infusional paclitaxel in combination with doxorubicin, cyclophosphamide, and peripheral blood…”
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Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis by TETEF, M. L, MARGOLIN, K. A, CARROLL, M. I, NEWMAN, E. M, DOROSHOW, J. H, AKMAN, S, LEONG, L. A, MORGAN, R. J, RASCHKO, J. W, SLATKIN, N, SOMLO, G, LONGMATE, J. A

“…To evaluate the pharmacokinetics and toxicity of high-dose intravenous (i.v.) methotrexate (MTX) with leucovorin in patients with meningeal carcinomatosis. Of…”
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A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies by Shibata, S.I, Pezner, R, Chu, D, Doroshow, J.H, Chow, W.A, Leong, L.A, Margolin, K.A, McNamara, M.V, Morgan, R.J, Raschko, J.W, Somlo, G, Tetef, M.L, Yen, Y, Synold, T.W, Wagman, L, Vora, N, Carroll, M, Lin, S, Longmate, J

“…Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically…”
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Effect of low-dose prophylactic dopamine on high-dose cisplatin-induced electrolyte wasting, ototoxicity, and epidermal growth factor excretion: a randomized, placebo-controlled, double-blind trial by Somlo, G, Doroshow, J H, Lev-Ran, A, Ahn, D C, Hwang, L, Raschko, J W, Forman, S J, Margolin, K A, Morgan, R J, Leong, L A

“…To evaluate the protective effect of low-dose dopamine given as continuous infusion in patients who undergo chemotherapy with the nephrotoxin cisplatin…”
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High-dose cisplatin, etoposide, and cyclophosphamide with autologous stem cell reinfusion in patients with responsive metastatic or high-risk primary breast cancer by Somlo, G, Doroshow, J H, Forman, S J, Leong, L A, Margolin, K A, Morgan, Jr, R J, Raschko, J W, Akman, S A, Ahn, C, Sniecinski, I

“…This study was designed to establish the feasibility of combining high-dose cisplatin, etoposide, and cyclophosphamide followed by stem cell rescue in patients…”
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Phase I study of mitomycin C and menadione in advanced solid tumors by MARGOLIN, K. A, AKMAN, S. A, LEONG, L. A, MORGAN, R. J, SOMLO, G, RASCHKO, J. W, CHUL AHN, DOROSHOW, J. H

“…A phase I study of mitomycin C with menadione (2-methyl-1,4-naphthoquinone, a vitamin K analogue which lowers intracellular pools of reduced glutathione) was…”
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Pharmacokinetics and toxicity of 120-hour continuous-infusion hydroxyurea in patients with advanced solid tumors by NEWMAN, E. M, CARROLL, M, SHIBATA, S, SOMLO, G, TETEF, M, YEN, Y, AHN, C. W, DOROSHOW, J. H, AKMAN, S. A, CHOW, W, COLUZZI, P, HAMASAKI, V, LEONG, L. A, MARGOLIN, K. A, MORGAN, R. J, RASCHKO, J. W

“…A group of 18 patients with advanced cancer were entered on a phase I study of a 120-h continuous intravenous infusion of hydroxyurea. The dose of hydroxyurea…”
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Effective initial therapy of advanced breast cancer with fluorouracil and high-dose, continuous infusion calcium leucovorin by Margolin, K A, Doroshow, J H, Akman, S A, Leong, L A, Morgan, R J, Raschko, J W, Somlo, G, Blevins, C

“…The use of leucovorin (LV) to modulate fluorouracil (FU)-mediated inhibition of thymidylate synthase has been shown both in vitro and in vivo to improve the…”
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Phase II trial of 5-fluorouracil and high-dose folinic acid as first- or second-line therapy for advanced breast cancer by Margolin, K A, Green, S, Osborne, K, Doroshow, J H, Akman, S A, Leong, L A, Morgan, R J, Raschko, J W, Somlo, G, Hutchins, L

“…The use of leucovorin to modulate 5-fluorouracil (FUra)-mediated inhibition of thymidylate synthase has been shown both in vitro and in vivo to improve the…”
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Pharmacokinetics and toxicity of continuous infusion (6S)-folinic acid and bolus 5-fluorouracil in patients with advanced cancer by NEWMAN, E. M, AKMAN, S. A, HARRISON, J. S, LEONG, L. A, MARGOLIN, K. A, MORGAN, R. J, RASCHKO, J. W, SOMLO, G, AHN, C. W, DOROSHOW, J. H

“…Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a…”
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Phase I study of 5-day continuous infusion fluorodeoxyuridine and high-dose folinic acid with oral hydroxyurea by RASCHKO, J. W, AKMAN, S. A, LEONG, L. A, MARGOLIN, K. A, MORGAN, R. J, NEWMAN, E, SOMLO, G, AHN, C, DOROSHOW, J. H

“…Fluorodeoxyuridine (FUdR), the deoxynucleoside metabolite of 5-fluorouracil (5-FU), can be converted in a single step to fluorodeoxyuridine monophosphate…”
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Pulmonary fibrosis after bone marrow transplantation responsive to treatment with prednisone and cyclosporine by Raschko, J W, Cottler-Fox, M, Abbondanzo, S L, Torrisi, J R, Spitzer, T R, Deeg, H J

“…Interstitial pneumonitis and biopsy-proven pulmonary fibrosis developed in a 35-year-old man with acute myeloblastic leukemia 4 months after conditioning with…”
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A phase I study of carboplatin and etoposide administered in conjunction with dipyridamole, prochlorperazine and cyclosporine A by RASCHKO, James W, SYNOLD, Timothy W, TETEF, Merry L, YUN YEN, TER VEER, Anna, DOROSHOW, James H, CHOW, Warren, COLUZZI, Paul, HAMASAKI, Victor, LEONG, Lucille A, MARGOLIN, Kim A, MORGAN, Robert J, SHIBATA, Stephen I, SOMLO, George

“…In recognition of the variety of available chemotherapeutic modulating agents and their potential to enhance the efficacy of platinum-based therapy, we…”
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Five-day infusion of fluorodeoxyuridine with high-dose oral leucovorin : a phase I study by VOKES, E. E, RASCHKO, J. W, VOGELZANG, N. J, WARFIELD, E. E, RATAIN, M. J, DOROSHOW, J. H, SCHILSKY, R. L

“…Fluorodeoxyuridine (FUdR) interferes with cellular metabolism by inhibiting thymidylate synthase. Therefore, we sought to modulate its activity with leucovorin…”
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Continuous infusion 5-fluorouracil with bolus adriamycin and mitomycin and low-dose cisplatin (FAMP) in the treatment of metastatic gastric carcinoma: an evaluation of efficacy and toxicity by Raschko, J W, Johnson, E A, Ueno, W, Woolley, P V, Treat, J

“…A pilot study was performed to evaluate the feasibility of administering prolonged continuous infusion 5-fluorouracil with multiple bolus chemotherapeutic…”
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High-dose doxorubicin, etoposide, and cyclophosphamide with stem cell reinfusion in patients with metastatic or high-risk primary breast cancer. City of Hope Bone Marrow Oncology Team by Somlo, G, Doroshow, J H, Forman, S J, Leong, L A, Margolin, K A, Morgan, Jr, R J, Raschko, J W, Akman, S A, Ahn, C, Nagasawa, S

“…Chemotherapy with a doxorubicin-containing regimen results in high overall response rates in the treatment of metastatic adenocarcinoma of the breast; the…”
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