Search Results - "Raschke, Marian"

Translating in vitro to in vivo and animal to human by Steger-Hartmann, Thomas, Raschke, Marian

“…This review summarizes the recent advances in the field of investigative toxicology with a particular focus on the toxicological endpoint drug-induced liver…”
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Rat pancreas tissue slices as in vitro model for studying drug-induced pancreatic toxicity by Hellmund, Maria, Raschke, Marian, Frisk, Anna-Lena

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Differentiation of Aneugens and Clastogens in the In Vitro Micronucleus Test by Kinetochore Scoring Using Automated Image Analysis by Wilde, Sabrina, Queisser, Nina, Holz, Christian, Raschke, Marian, Sutter, Andreas

“…The in vitro micronucleus test according to OECD Test Guideline 487 (TG 487) is widely used to investigate the genotoxic potential of drugs. Besides the…”
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Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model by Hübner, Juliane, Raschke, Marian, Rütschle, Isabel, Gräßle, Sarah, Hasenberg, Tobias, Schirrmann, Kerstin, Lorenz, Alexandra, Schnurre, Susanne, Lauster, Roland, Maschmeyer, Ilka, Steger-Hartmann, Thomas, Marx, Uwe

“…Antibody therapies targeting the epithelial growth factor receptor (EGFR) are being increasingly applied in cancer therapy. However, increased tumour…”
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Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688 by Battista, Christina, Shoda, Lisl K.M., Watkins, Paul B., Groettrup‐Wolfers, Esther, Rottmann, Antje, Raschke, Marian, Generaux, Grant T.

“…BAY1128688 is a selective inhibitor of AKR1C3, investigated recently in a trial that was prematurely terminated due to drug‐induced liver injury. These…”
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A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization by Stock, Valerie, Sutter, Andreas, Raschke, Marian, Queisser, Nina, Gollapudi, B.

“…Chemical‐induced disruption of the cellular microtubule network is one key mechanism of aneugenicity. Since recent data indicate that genotoxic effects of…”
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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity by Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

“…Monopolar spindle 1 (Mps1) has been shown to function as the key kinase that activates the spindle assembly checkpoint (SAC) to secure proper distribution of…”
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Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer by Mowat, Jeffrey, Carretero, Rafael, Leder, Gabriele, Aiguabella Font, Nuria, Neuhaus, Roland, Berndt, Sandra, Günther, Judith, Friberg, Anders, Schäfer, Martina, Briem, Hans, Raschke, Marian, Miyatake Ondozabal, Hideki, Buchmann, Bernd, Boemer, Ulf, Kreft, Bertolt, Hartung, Ingo V., Offringa, Rienk

“…Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a serine/threonine kinase that acts as an immune checkpoint downstream of T-cell receptor…”
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A microfluidic thyroid-liver platform to assess chemical safety in humans by Kühnlenz, Julia, Karwelat, Diana, Steger-Hartmann, Thomas, Raschke, Marian, Bauer, Sophie, Vural, Özlem, Marx, Uwe, Tinwell, Helen, Bars, Remi

“…Thyroid hormones (THs) are crucial regulators of human metabolism and early development. During the safety assessment of plant protection products, the human…”
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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase by Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

“…Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are…”
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A rodent thyroid-liver chip to capture thyroid toxicity on organ function level by Karwelat, Diana, Kühnlenz, Julia, Steger-Hartmann, Thomas, Bars, Remi, Tinwell, Helen, Marx, Uwe, Bauer, Sophie, Born, Oliver, Raschke, Marian

“…Endocrine disruption by environmental chemicals continues to be a concern for human safety. The rat, a widely used model organism in toxicology, is very…”
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New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension by Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus

“…Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the…”
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Abstract LB-027: Evaluation of EGFR induced on-target and target-mediated adverse effects in a 3D human lung tumour/skin microphysiological co-culture system by Huebner, Juliane, Raschke, Marian, Schimek, Katharina, Ruetschle, Isabel, Graessle, Sarah, Schnurre, Susanne, Lauster, Roland, Maschmeyer, Ilka, Steger-Hartmann, Thomas, Marx, Uwe

“…Abstract Organs-on-a-chip or microphysiological systems (MPS) are increasingly contributing to the preclinical characterization of mode of action and adverse…”
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Fail Early, Fail Cheap: Project Termination During Lead Optimization Due to Mitochondrial Toxicity by Himmel, Herbert, Raschke, Marian, Siemeister, Gerhard, Baerfacker, Lars, Ruehl-Fehlert, Christine, Zierz, Rupprecht

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A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay by Igl, Bernd-Wolfgang, Dertinger, Stephen D., Dobrovolsky, Vasily N., Raschke, Marian, Sutter, Andreas, Vonk, Richardus

“…•The proposed statistical model uses both treatment and longitudinal information.•Treatment and longitudinal effects can be determined within and between…”
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Best practices for application of attachment cells to in vitro micronucleus assessment by flow cytometry by Bemis, Jeffrey C., Bryce, Steven M., Nern, Marlies, Raschke, Marian, Sutter, Andreas

“…•We provide best practices information for the conduct of the in vitro micronucleus assay.•The information covers cell handling, exposure, processing,…”
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Comparison of the Mesoscale Discovery and Luminex multiplex platforms for measurement of urinary biomarkers in a cisplatin rat kidney injury model by Pavkovic, Mira, Riefke, Björn, Gutberlet, Katrin, Raschke, Marian, Ellinger-Ziegelbauer, Heidrun

“…In the past years several new urinary nephrotoxicity biomarkers have been qualified for use in preclinical studies by the FDA and EMA. Subsequently, kits have…”
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The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury by Ellinger-Ziegelbauer, Heidrun, Adler, Melanie, Amberg, Alexander, Brandenburg, Arnd, Callanan, John J., Connor, Susan, Fountoulakis, Michael, Gmuender, Hans, Gruhler, Albrecht, Hewitt, Philip, Hodson, Mark, Matheis, Katja A., McCarthy, Diane, Raschke, Marian, Riefke, Björn, Schmitt, Christina S., Sieber, Max, Sposny, Alexandra, Suter, Laura, Sweatman, Brian, Mally, Angela

“…The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of…”
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Abstract 1163: Phosphoserine aminotransferase 1 (PSAT1) as a novel anti-tumor target in hepatocellular carcinoma by Ding, Zhaobing, Wee, Kenneth, Kim, Eung-Sam, Samanta, Animesh, Steckel, Michael, Raschke, Marian, Velan, Sendhil, Chang, Young-Tae, Haegebarth, Andrea, Ziegelbauer, Karl, Gruenewald, Sylvia, Han, Weiping

“…Abstract With an estimated 700,000 new cases per year, hepatocellular carcinoma (HCC) represents the fifth commonest cancer and is the third leading cause of…”
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The Role of Residual Gadolinium in the Induction of Nephrogenic Systemic Fibrosis-Like Skin Lesions in Rats by Pietsch, Hubertus, Raschke, Marian, Ellinger-Ziegelbauer, Heidrun, Jost, Gregor, Walter, Jakob, Frenzel, Thomas, Lenhard, Diana, Hütter, Joachim, Sieber, Martin A

“…OBJECTIVE:Nephrogenic systemic fibrosis (NSF) is an acquired, idiopathic disorder. Most of the cases are observed in patients with end stage renal disease…”
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