Hypogammaglobulinemia and anemia 18 years after thymoma resection

Immunodeficiency with a thymoma (Good's syndrome) is a rare condition occurring in 7% to 13% of patients with adult-onset hypogammaglobulinemia. In 80% of cases, hypogammaglobulinemia is detected within 5 years of the identification of the thymoma. A 70-year-old man was found to have hypogammag...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 100; no. 6; pp. 846 - 848
Main Authors:	Raschal, Susan, Siegel, Joan N., Huml, Jeffrey, Richmond, G.Wendell
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-12-1997 Elsevier
Subjects:	Agammaglobulinemia - etiology Agammaglobulinemia - immunology Anemia - etiology Anemia - immunology Biological and medical sciences Cytokines - biosynthesis Good's syndrome Humans Hypogammaglobulinemia Immunodeficiencies. Immunoglobulinopathies immunodeficiency Immunoglobulinopathies Immunopathology Immunophenotyping Male Mediastinal Neoplasms - immunology Mediastinal Neoplasms - surgery Medical sciences Middle Aged Syndrome T-Lymphocyte Subsets - classification T-Lymphocyte Subsets - metabolism thymoma Thymoma - immunology Thymoma - surgery IFN PHA Good's syndrome Hypogammaglobulinemia immunodeficiency thymoma PBMC Human Immunopathology Thymoma Mediastinum disease Anemia Agammaglobulinemia Male Hemopathy Thymus pathology Case study Treatment Immunoglobulinopathy Exeresis Surgery Tumor Adult
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Summary:	Immunodeficiency with a thymoma (Good's syndrome) is a rare condition occurring in 7% to 13% of patients with adult-onset hypogammaglobulinemia. In 80% of cases, hypogammaglobulinemia is detected within 5 years of the identification of the thymoma. A 70-year-old man was found to have hypogammaglobulinemia 18 years after a thymoma had been resected. Cellular immunophenotyping revealed there were no detectable B cells, decreased CD4 + cells, and increased CD8 + cells. Both CD4 + and CD8 + subsets expressed increased populations of CD38 + DR + cells and CD45RO + cells. The CD8 + CD28 + population was markedly reduced. Inducible cytokine production by the patient's peripheral blood mononuclear cells revealed decreased IL-2, IL-10, and interferon-γ production. These data suggest that patients with Good's syndrome have activated memory T cells that have dysregulated cytokine production. (J Allergy Clin Immunol 1997;100:846-8.)
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0091-6749 1097-6825
DOI:	10.1016/S0091-6749(97)70283-5