Search Results - "Rapraeger, A C"

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins by Jung, O, Trapp-Stamborski, V, Purushothaman, A, Jin, H, Wang, H, Sanderson, R D, Rapraeger, A C

“…Multiple myeloma arises when malignant plasma cells invade and form multiple tumors in the bone marrow. High levels of heparanase (HPSE) correlate with poor…”
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Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4 by GUIMOND, S, MACCARANA, M, OLWIN, B. B, LINDAHL, U, RAPRAEGER, A. C

“…Chlorate-treated Swiss 3T3 fibroblasts, with impaired synthesis of heparan sulfate proteoglycan, were used as target cells in assessing the ability of…”
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Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues by Friedl, A, Chang, Z, Tierney, A, Rapraeger, AC

“…Fibroblast growth factors (FGFs) play multiple roles during development and in adult tissues as paracrine regulators of growth and differentiation. FGFs signal…”
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Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation by Rapraeger, Alan C., Krufka, Alison, Olwin, Bradley B.

“…Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of…”
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Post-Transcriptional Regulation of Syndecan-1 Expression by cAMP in Peritoneal Macrophages by Yeaman, Charles, Rapraeger, Alan C.

“…Syndecan-1 is a cell surface heparan sulfate proteoglycan that is proposed to serve in cell-cell adhesion, cell-matrix anchorage, and growth factor signaling…”
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Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations by REILAND, J, RAPRAEGER, A. C

“…Basic FGF is a prototype of a family of heparin binding growth factors that regulate a variety of cellular responses including cell growth, morphogenesis and…”
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Syndecan-Regulated Receptor Signaling by Rapraeger, Alan C.

“…The syndecans are transmembrane heparan sulfate (HS) proteoglycans expressed on all adherent cells. Iba et al describe an important regulation of integrin…”
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Syndecan-3 and Syndecan-4 Specifically Mark Skeletal Muscle Satellite Cells and Are Implicated in Satellite Cell Maintenance and Muscle Regeneration by Cornelison, D.D.W., Filla, Mark S., Stanley, Heather M., Rapraeger, Alan C., Olwin, Bradley B.

“…Myogenesis in the embryo and the adult mammal consists of a highly organized and regulated sequence of cellular processes to form or repair muscle tissue that…”
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Regulation by heparan sulfate in fibroblast growth factor signaling by Rapraeger, A C, Guimond, S, Krufka, A, Olwin, B B

“…The integral role of heparan sulfate proteoglycans in FGF signaling provides a potential means of regulating FGF activity. This regulation may be used by the…”
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Heparan sulfate proteoglycans from mouse mammary epithelial cells. A putative membrane proteoglycan associates quantitatively with lipid vesicles by Rapraeger, A C, Bernfield, M

“…Mouse mammary epithelial (NMuMG) cells produce both cellular and extracellular heparan sulfate-rich proteoglycans. A cellular proteoglycan, but no…”
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Molecular interactions of syndecans during development by Rapraeger, Alan C

“…The syndecans, cell surface heparan sulfate proteoglycans (HSPGs), bind numerous ligands via their HS glycosaminoglycan chains. The response to this binding is…”
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Membrane-anchored proteoglycans of mouse macrophages: P388D1 cells express a syndecan-4-like heparan sulfate proteoglycan and a distinct chondroitin sulfate form by Yeaman, C, Rapraeger, A C

“…Proteoglycan accumulation by thioglycollate-elicited mouse peritoneal macrophages and a panel of murine monocyte-macrophage cell lines has been examined to…”
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Role of Heparan Sulfate as a Tissue-Specific Regulator of FGF-4 and FGF Receptor Recognition by Allen, Benjamin L., Filla, Mark S., Rapraeger, Alan C.

“…FGF signaling uses receptor tyrosine kinases that form high-affinity complexes with FGFs and heparan sulfate (HS) proteoglycans at the cell surface. It is…”
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Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ by CHANG, ZHEN, MEYER, KRISTY, RAPRAEGER, ALAN C., FRIEDL, ANDREAS

“…ABSTRACT Fibroblast growth factors (FGFs) require heparan sulfate proteoglycans (HSPGs) as cofactors for signaling. The heparan sulfate chains (HS) mediate…”
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Molecular interactions of the syndecan core proteins by Rapraeger, Alan C, Ott, Vanessa L

“…The syndecan family of cell-surface heparan sulfate proteoglycans participate in multiple cell behaviors ranging from growth factor signaling to cell adhesion…”
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Tissue-specific binding by FGF and FGF receptors to endogenous heparan sulfates by Friedl, A, Filla, M, Rapraeger, A C

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Characterization of the High Affinity Cell-binding Domain in the Cell Surface Proteoglycan Syndecan-4 by McFall, Aidan J., Rapraeger, Alan C.

“…The syndecan family of cell surface proteoglycans regulates cell adhesion via their glycosaminoglycan chains and discrete domains of their core proteins. Core…”
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Tyrosine Phosphorylation of Syndecan-1 and -4 Cytoplasmic Domains in Adherent B82 Fibroblasts by Ott, V L, Rapraeger, A C

“…The syndecans, a family of cell surface proteoglycans, have highly conserved cytoplasmic domains that bind proteins containing PDZ domains and co-localize with…”
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Syndecan-1 Mediates Cell Spreading in Transfected Human Lymphoblastoid (Raji) Cells by Lebakken, Connie S., Rapraeger, Alan C.

“…Syndecan-1 is a cell surface proteoglycan containing a highly conserved transmembrane and cytoplasmic domain, and an extracellular domain bearing heparan…”
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Two Hierarchies of FGF-2 Signaling in Heparin:  Mitogenic Stimulation and High-Affinity Binding/Receptor Transphosphorylation by Krufka, Alison, Guimond, Scott, Rapraeger, Alan C

“…FGF-2 activates multiple signaling pathways by a cell surface signaling complex assembled with FGF, its receptor tyrosine kinase, and heparan sulfate…”
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