Search Results - "Rappolee, D.A"

High throughput screen using viable fluorescent ESC reporter of stress forced differentiation to the first lineage by Puscheck, E.E, Yang, Y, Rappolee, D.A

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Validation of a high throughput screen (HTS) for viable fluorescent ESC reporters of stressed-induced of differentiation of the first lineage by Puscheck, E.E, Li, Q, Yang, Y, Rappolee, D.A

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Development of a viable double potency factor reporter for high throughput screens of stress responses in embryonic stem cells by Puscheck, E.E, Li, Q, Yang, Y, Rappolee, D.A

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Impact of transient stress and stress enzymes on development by Rappolee, D.A.

“…Stress enzymes triggered by transient stress mediate reprioritization of developmental and homeostatic events to flexibly accomplish the next essential…”
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Pipetting causes shear stress and elevation of phosphorylated stress-activated protein kinase/jun kinase in preimplantation embryos by Xie, Y., Wang, F., Puscheck, E.E., Rappolee, D.A.

“…Shear stress at 1.2 dynes/cm2 induces stress‐activated protein kinase/jun kinase phosphorylation that precedes and causes apoptosis in embryos (Xie et al.,…”
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SAPK activity is a better marker than AMPK activity for measuring stressful O2 levels in stem cells by Puscheck, E.E, Jiang, Z, Xie, Y.F, Zhou, S.C, Rappolee, D.A

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Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress by Zhou, S, Xie, Y, Puscheck, E.E, Rappolee, D.A

“…Abstract Accumulating data suggest that 20% O2 causes human and mouse placental trophoblast stem cell (TSC) differentiation and suppresses proliferation. We…”
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cellular and toxicological stress causes adaptive “PRIORITIZED” AND “Compensatory” differentiation of embryonic and placental stem cells of the implanting blastocyst by Rappolee, D.A, Xie, Y.F, Zhou, S.C, Slater, J, Puscheck, E.E

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Hypoxia induces maximal preparation for, but incomplete differentiation of stem cells that is associated with decreased mitochondrial function and increased expression of two potency factors by Rappolee, D.A, Xie, Y.F, Zhou, S.C, Huttemann, M, Lee, I.S, Puscheck, E.E

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Hyperosmolar Stress Induces Global mRNA Responses in Placental Trophoblast Stem Cells that Emulate Early Post-implantation Differentiation by Liu, J, Xu, W, Sun, T, Wang, F, Puscheck, E, Brigstock, D, Wang, Q.T, Davis, R, Rappolee, D.A

“…Abstract Hyperosmolar stress acts in two ways on the implanting embryo and its major constituent, placental trophoblast stem cells (TSC). Stress causes…”
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Eomesodermin, HAND1, and CSH1 proteins are induced by cellular stress in a stress-activated protein kinase-dependent manner by Awonuga, A.O., Zhong, W., Abdallah, M.E., Slater, J.A., Zhou, S.C., Xie, Y.F., Puscheck, E.E., Rappolee, D.A.

“…Eomesodermin (Eomes) is a transcription factor essential for trophoblast development. Stress stimuli activate stress‐activated protein kinase (MAPK8/9) and…”
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Benzopyrene activates SAPK and induces HAND1 that favors differentiation of trophoblast stem cells by Abdallah, M, Xie, Y, Puscheck, E.E, Rappolee, D.A, Awonuga, A.O

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Impact of stress and stress enzymes on early mammalian development by Slater, J, Puscheck, E.E, Zhou, S, Xie, Y, Rappolee, D.A

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Eomesodermin (Eomes) and heart and neural crest derivatives expressed (HAND)1 are upregulated by stress in trophoblast stem cells in a stress activated protein kinase (SAPK)-dependent manner by Awonuga, A.O, Abdallah, M.E, Xie, Y, Diamond, M.P, Puscheck, E.E, Rappolee, D.A

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Two-cell embryos express distinct populations of Cdx2 that bind Oct4 or are phosphorylated on serine 60 by Xie, Y, Puscheck, E.E, Liu, J, Rappolee, D.A

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Stress rapidly down regulates inhibitor of differentiation 2 in trophoblast stem cells via AMP activated Kinase-dependent pathway by Abdallah, M.E, Awonuga, A.O, Xie, Y, Puscheck, E.E, Daimond, M.P, Rappolee, D.A

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Impact of stress and stress enzymes on early mammalian development by Puscheck, E.E, Xie, Y, Liu, J, Proteasa, S, Proteasa, G, Rappolee, D.A

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Mitochondrial inhibition during 20% o2culture is sufficient to emulate hypoxic-stress induced potency loss and TGC differentiation in MTSC by Puscheck, E., Yang, Y., Rappolee, D.A.

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WITHDRAWN: Novel high throughput screen reports that benzo(a)pyrene overrides trophoblast stem cell multipotency, inducing SAPK activity, HAND1 and differentiated trophoblast giant cells by Kidder, B.L., Ruden, X., Singh, A., Marben, T.A., Rass, L., Chakravarty, A., Xie, Y., Puscheck, E.E., Awonuga, A.O., Harris, S., Ruden, D.M., Rappolee, D.A.

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High throughput screens using stress-forced ESC identify and classify drugs by embryotoxicity and dose-dependent stress effects by Puscheck, E., Perez, G., Dutta, S., Abdulhasan, M., Louden, E., Rappolee, D.A.

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