Search Results - "Rappley, Irit"

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin by Penchala, Sravan C., Connelly, Stephen, Wang, Yu, Park, Miki S., Zhao, Lei, Baranczak, Aleksandra, Rappley, Irit, Vogel, Hannes, Liedtke, Michaela, Witteles, Ronald M., Powers, Evan T., Reixach, Natàlia, Chan, William K., Wilson, Ian A., Kelly, Jeffery W., Graef, Isabella A., Alhamadsheh, Mamoun M.

“…The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac…”
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Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange by Rappley, Irit, Monteiro, Cecília, Novais, Marta, Baranczak, Aleksandra, Solis, Gregory, Wiseman, R. Luke, Helmke, Stephen, Maurer, Mathew S, Coelho, Teresa, Powers, Evan T, Kelly, Jeffery W

“…The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation. Kinetic…”
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CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML) by Lopez-Girona, Antonia, Lu, Gang, Rychak, Emily, Mendy, Derek, Lu, Chin-Chun, Rappley, Irit, Fontanillo, Celia, Cathers, Brian E., Daniel, Thomas O., Hansen, Joshua

“…The cereblon E3 ligase modulator (CELMoD) CC-885 co-opts the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex to trigger the ubiquitination and…”
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Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype by Rappley, Irit, Myers, David S, Milne, Stephen B, Ivanova, Pavlina T, LaVoie, Matthew J, Brown, H. Alex, Selkoe, Dennis J

“…Advances in lipidomics technology have facilitated the precise detection, identification and profiling of lipid species within tissues. Mass spectrometry…”
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Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets by Rudnick, Jenny, Nadella, Kiran, Neumann, Chase, Rowley, Shane, Gardner, Ethan, Swaidani, Shadi, Iberg, Aimee, Chen, Lu, Beshnova, Daria, Blucher, Aurora, Basso, Rebecca Sarto, Rajan, Malini, Fales, Kevin, Saeed, Ashraf, Bailey, Christopher, Judd, Weston, Egbert, Chrissy, Ellis, Joel, Ansede, John, Hadipour, Pouya, Jessing, Kevin, Paulsen, Janet, Rearden, Paul, Manda, Vamshi, Kasimsetty, Sashi, Hancock, Michael, Shankaran, Harish, Ellis, Bryan, Iyer, Meenakshy, Brooks, Carl, Bhandari, Ashish, Gibson, Chris, Rappley, Irit, Schaevitz, Laura, Haque, Imran, Donnella, Hayley, Cuccarese, Michael, Evangelista, Marie

“…Abstract The emergence of technological innovations has created the opportunity to envision new approaches to discover therapeutics at scale. We combined…”
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Evidence That α-Synuclein Does Not Inhibit Phospholipase D by Rappley, Irit, Gitler, Aaron D, Selvy, Paige E, LaVoie, Matthew J, Levy, Bruce D, Brown, H. Alex, Lindquist, Susan, Selkoe, Dennis J

“…α-Synuclein (αSyn) is a small cytosolic protein of unknown function, which is highly enriched in the brain. It is genetically linked to Parkinson’s disease…”
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Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with [alpha]-synuclein genotype by Rappley, Irit, Myers, David S, Milne, Stephen B, Ivanova, Pavlina T, LaVoie, Matthew J, Brown, H Alex, Selkoe, Dennis J

“…Advances in lipidomics technology have facilitated the precise detection, identification and profiling of lipid species within tissues. Mass spectrometry…”
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Evidence That a-Synuclein Does Not Inhibit Phospholipase D by Rappley, Irit, Gitler, Aaron D, Selvy, Paige E, Lavoie, Matthew J, Levy, Bruce D, Brown, H Alex, Lindquist, Susan, Selkoe, Dennis J

“…*a-Synuclein (*aSyn) is a small cytosolic protein of unknown function, which is highly enriched in the brain. It is genetically linked to Parkinson's disease…”
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Selective effects of alpha-synuclein on membrane phospholipids and mitochondrial function by Rappley, Irit

“…α-Synuclein (αSyn) is a small cytosolic protein that is highly enriched in neurons, particularly at presynaptic terminals, and has been implicated in the…”
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