Search Results - "Rappailles, Aurélien"
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Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes
Published in Genome research (01-04-2010)“…Neutral nucleotide substitutions occur at varying rates along genomes, and it remains a major issue to unravel the mechanisms that cause these variations and…”
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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome
Published in PLoS computational biology (01-12-2011)“…Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by…”
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Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines
Published in PLoS computational biology (01-04-2012)“…In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about…”
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From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains
Published in Journal of molecular biology (29-11-2013)“…The Replicon Theory proposed 50years ago has proven to apply for replicons of the three domains of life. Here, we review our knowledge of genome organization…”
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Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm
Published in Nature protocols (01-01-2013)“…In this protocol, we describe the use of the LastWave open-source signal-processing command language ( http://perso.ens-lyon.fr/benjamin.audit/LastWave/ ) for…”
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Recruitment of Drosophila polycomb group proteins to chromatin by DSP1
Published in Nature (24-03-2005)“…Polycomb and trithorax group (PcG and trxG) proteins maintain silent and active transcriptional states, respectively, throughout development. In Drosophila,…”
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Replication-Associated Mutational Asymmetry in the Human Genome
Published in Molecular biology and evolution (01-08-2011)“…During evolution, mutations occur at rates that can differ between the two DNA strands. In the human genome, nucleotide substitutions occur at different rates…”
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Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome: e1002322
Published in PLoS computational biology (01-12-2011)“…Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by…”
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DSP1, a Drosophila HMG protein, is involved in spatiotemporal expression of the homoeotic gene Sex combs reduced
Published in Biology of the cell (01-10-2005)“…Background information. The Pc‐G (Polycomb group) and trx‐G (trithorax group) genes play a key role in the regulation of the homoeotic genes. The homoeotic…”
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