Search Results - "Rapoport, S I"

Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients by Rao, J S, Harry, G J, Rapoport, S I, Kim, H W

“…Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD) suggest that the disease progresses over time. The worsening…”
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Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients by Rao, J S, Keleshian, V L, Klein, S, Rapoport, S I

“…Alzheimer's disease (AD) and bipolar disorder (BD) are progressive brain disorders. Upregulated mRNA and protein levels of neuroinflammatory and arachidonic…”
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n-3 Polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism by RAO, J. S, ERTLEY, R. N, LEE, H.-J, DEMAR, J. C, ARNOLD, J. T, RAPOPORT, S. I, BAZINET, R. P

“…Decreased docosahexaenoic acid (DHA) and brain-derived neurotrophic factor (BDNF) have been implicated in bipolar disorder. It also has been reported that…”
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Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? by Rao, J S, Lee, H-J, Rapoport, S I, Bazinet, R P

“…Bipolar disorder is a major medical, social and economic burden worldwide. However, the mechanisms of action of effective antibipolar disorder drugs remain…”
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Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients by Kim, H-W, Rapoport, S I, Rao, J S

“…Mood stabilizers that are approved for treating bipolar disorder (BD), when given chronically to rats, decrease expression of markers of the brain arachidonic…”
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Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex by RAO, J. S, ERTLEY, R. N, DEMAR, J. C, RAPOPORT, S. I, BAZINET, R. P, LEE, H.-J

“…The enzymes that regulate the brain arachidonic acid (AA) cascade have been implicated in bipolar disorder and neuroinflammation. Fifteen weeks of dietary n-3…”
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Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E2 concentration in rat brain by BOSETTI, F, RINTALA, J, SEEMANN, R, ROSENBERGER, T. A, CONTRERAS, M. A, RAPOPORT, S. I, CHANA, M. C

“…Rats treated with lithium chloride for 6 weeks have been reported to demonstrate reduced turnover of arachidonic acid (AA) in brain phospholipids, and…”
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The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults by DECARLI, C, MURPHY, D. G. M, SCHAPIRO, M. B, TRANH, M, GRADY, C. L, HAXBY, J. V, GILLETTE, J. A, SALERNO, J. A, GONZALES-AVILES, A, HORWITZ, B, RAPOPORT, S. I

“…To assess the association of MRI white matter hyperintensities (WMHI) with cognitive performance, cerebral structure, and cerebral metabolism in 51 healthy…”
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Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease by IBANEZ, V, PIETRINI, P, ALEXANDER, G. E, FUREY, M. L, TEICHBERG, D, RAJAPAKSE, J. C, RAPOPORT, S. I, SCHAPIRO, M. B, HORWITZ, B

“…To determine whether the hypometabolism observed in PET images of patients with Alzheimer's disease (AD) is due entirely to brain atrophy. Reduced brain…”
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Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy by Rapoport, S I

“…The blood-brain barrier (BBB) to water-soluble drugs and macromolecules can be opened in vivo by infusing a hypertonic solution of arabinose or mannitol into…”
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Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to 'switching' in bipolar disorder? by Lee, H-J, Rao, J S, Chang, L, Rapoport, S I, Kim, H-W

“…Agents effective against mania in bipolar disorder are reported to decrease turnover of arachidonic acid (AA) in phospholipids and expression of…”
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Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome by Siarey, R.J., Stoll, J., Rapoport, S.I., Galdzicki, Z.

“…We investigated the phenomenon of long-term potentiation (LTP) in a genetic model of Down Syndrome, the segmental trisomy mouse (Ts65Dn). Ts65Dn mice survive…”
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Is phosphoadenosine phosphate phosphatase a target of lithium’s therapeutic effect? by Shaltiel, G., Deutsch, J., Rapoport, S. I., Basselin, M., Belmaker, R. H., Agam, G.

“…Lithium, which is approved for treating patients with bipolar disorder, is reported to inhibit 3′(2′)-phosphoadenosine-5′-phosphate (PAP) phosphatase activity…”
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Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer’s disease in relation to dementia severity: evidence for early neocortical degeneration by Teipel, S.J, Bayer, W, Alexander, G.E, Bokde, A.L.W, Zebuhr, Y, Teichberg, D, Müller-Spahn, F, Schapiro, M.B, Möller, H.-J, Rapoport, S.I, Hampel, H

“…We used volumetric MRI and analysis of areas under receiver operating characteristic (ROC) curves to directly compare the extent of hippocampus–amygdala…”
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Network analysis of cortical visual pathways mapped with PET by McIntosh, AR, Grady, CL, Ungerleider, LG, Haxby, JV, Rapoport, SI, Horwitz, B

“…Brain metabolic mapping techniques, such as positron emission tomography (PET), can provide information about the functional interactions within entire neural…”
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Face Encoding and Recognition in the Human Brain by Haxby, James V., Ungerleider, Leslie G., Horwitz, Barry, Jose Ma. Maisog, Rapoport, Stanley I., Grady, Cheryl L.

“…A dissociation between human neural systems that participate in the encoding and later recognition of new memories for faces was demonstrated by measuring…”
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Cholinergic Stimulation Alters Performance and Task-Specific Regional Cerebral Blood Flow During Working Memory by Furey, M. L., Pietrini, P., Haxby, J. V., Alexander, G. E., Lee, H. C., VanMeter, J., Grady, C. L., Shetty, U., Rapoport, S. I., Schapiro, M. B., Freo, U.

“…Modulation of the cholinergic neurotransmitter system results in changes in memory performance, including working memory (WM), in animals and in patients with…”
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Dissociation of Object and Spatial Visual Processing Pathways in Human Extrastriate Cortex by Haxby, James V., Grady, Cheryl L., Horwitz, Barry, Ungerleider, Leslie G., Mishkin, Mortimer, Carson, Richard E., Herscovitch, Peter, Schapiro, Mark B., Rapoport, Stanley I.

“…The existence and neuroanatomical locations of separate extrastriate visual pathways for object recognition and spatial localization were investigated in…”
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Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome by Siarey, Richard J, Carlson, Elaine J, Epstein, Charles J, Balbo, Andrea, Rapoport, Stanley I, Galdzicki, Zygmunt

“…Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse…”
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Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer’s disease brain by Rao, J S, Rapoport, S I, Kim, H-W

“…Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A recent positron emission tomography…”
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