Search Results - "Raplee, Isaac"

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice by Xu, Lei, Surathu, Anil, Raplee, Isaac, Chockalingam, Ashok, Stewart, Sharron, Walker, Lacey, Sacks, Leonard, Patel, Vikram, Li, Zhihua, Rouse, Rodney

“…Emergence of antibiotic resistance is a global public health concern. The relationships between antibiotic use, the gut community composition, normal…”
Get full text

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits by Datta, Meenal, Via, Laura E, Dartois, Véronique, Weiner, Danielle M, Zimmerman, Matthew, Kaya, Firat, Walker, April M, Fleegle, Joel D, Raplee, Isaac D, McNinch, Colton, Zarodniuk, Maksym, Kamoun, Walid S, Yue, Changli, Kumar, Ashwin S, Subudhi, Sonu, Xu, Lei, Barry, 3rd, Clifton E, Jain, Rakesh K

“…Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and…”
Get full text

Emergence of nosocomial associated opportunistic pathogens in the gut microbiome after antibiotic treatment by Raplee, Isaac, Walker, Lacey, Xu, Lei, Surathu, Anil, Chockalingam, Ashok, Stewart, Sharron, Han, Xiaomei, Rouse, Rodney, Li, Zhihua

“…According to the Centers for Disease Control's 2015 Hospital Acquired Infection Hospital Prevalence Survey, 1 in 31 hospital patients was infected with at…”
Get full text

Aligning the Aligners: Comparison of RNA Sequencing Data Alignment and Gene Expression Quantification Tools for Clinical Breast Cancer Research by Raplee, Isaac D, Evsikov, Alexei V, Marín de Evsikova, Caralina

“…The rapid expansion of transcriptomics and affordability of next-generation sequencing (NGS) technologies generate rocketing amounts of gene expression data…”
Get full text

The Transcriptomic Toolbox: Resources for Interpreting Large Gene Expression Data within a Precision Medicine Context for Metabolic Disease Atherosclerosis by Marín de Evsikova, Caralina, Raplee, Isaac D, Lockhart, John, Jaimes, Gilberto, Evsikov, Alexei V

“…As one of the most widespread metabolic diseases, atherosclerosis affects nearly everyone as they age; arteries gradually narrow from plaque accumulation over…”
Get full text

Abstract 2248: Dynamic changes in transposon expression and epigenetic regulators detected during early breast cancer transition to malignancy by Raplee, Isaac D., Evsikov, Alexei, Evsikova, Caralina Marin de

“…Abstract Introduction: Breast cancer is the second leading cause of cancer-related deaths in women. In 2017, about 315,000 women were diagnosed with breast…”
Get full text

Contribution of Retrotransposons to Breast Cancer Malignancy by Raplee, Isaac D

“…The components contributing to cancer progression, especially the transition from early to invasive are unknown. Consequently, the biological reasons are…”
Get full text

Abstract 2040: Indication switching of the FDA-approved anticancer tyrosine kinase inhibitors to treat metabolic diseases by Sun, Jiazhi, Yang, Lun, Li, Minghua, Wang, Zhixin, Haynes, Amy, Wang, Qian, Raplee, Isaac, Melchisedek, Jean, Prasad, Anand, Sneed, Kevin B., He, Lin, Zhou, Shufeng

“…Abstract Drug switching is a unique way to identify and extend new indications for approved drugs in drug discovery & development. Tyrosine kinase inhibitors…”
Get full text