Search Results - "Rape, Andrew"

Microenvironmental stiffness enhances glioma cell proliferation by stimulating epidermal growth factor receptor signaling by Umesh, Vaibhavi, Rape, Andrew D, Ulrich, Theresa A, Kumar, Sanjay

“…The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the…”
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A composite hydrogel platform for the dissection of tumor cell migration at tissue interfaces by Rape, Andrew D, Kumar, Sanjay

“…Abstract Glioblastoma multiforme (GBM), the most prevalent primary brain cancer, is characterized by diffuse infiltration of tumor cells into brain tissue,…”
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The regulation of traction force in relation to cell shape and focal adhesions by Rape, Andrew D, Guo, Wei-hui, Wang, Yu-li

“…Abstract Mechanical forces provide critical inputs for proper cellular functions. The interplay between the generation of, and response to, mechanical forces…”
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A synthetic hydrogel for the high-throughput study of cell–ECM interactions by Rape, Andrew D., Zibinsky, Mikhail, Murthy, Niren, Kumar, Sanjay

“…It remains extremely challenging to dissect the cooperative influence of multiple extracellular matrix (ECM) parameters on cell behaviour. This stems in part…”
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Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion by Thomas, Dustin G, Yenepalli, Aishwarya, Denais, Celine Marie, Rape, Andrew, Beach, Jordan R, Wang, Yu-Li, Schiemann, William P, Baskaran, Harihara, Lammerding, Jan, Egelhoff, Thomas T

“…Non-muscle myosin II (NMII) is reported to play multiple roles during cell migration and invasion. However, the exact biophysical roles of different NMII…”
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Migration regulates cellular mechanical states by Chang, Stephanie S, Rape, Andrew D, Wong, Stephanie A, Guo, Wei-Hui, Wang, Yu-Li

“…Recent studies indicate that adherent cells are keenly sensitive to external physical environment, such as substrate rigidity and topography, and internal…”
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Carbon Nanotubes Reorganize Actin Structures in Cells and ex Vivo by Holt, Brian D, Short, Philip A, Rape, Andrew D, Wang, Yu-li, Islam, Mohammad F, Dahl, Kris Noel

“…The ability of globular actin to form filaments and higher-order network structures of the cytoskeleton is essential for cells to maintain their shape and…”
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Microtubule depolymerization induces traction force increase through two distinct pathways by Rape, Andrew, Guo, Wei-hui, Wang, Yu-li

“…Traction forces increase after microtubule depolymerization; however, the signaling mechanisms underlying this, in particular the dependence upon myosin II,…”
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Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates by Booth-Gauthier, Elizabeth A, Du, Vicard, Ghibaudo, Marion, Rape, Andrew D, Dahl, Kris Noel, Ladoux, Benoit

“…Cell migration through tight interstitial spaces in three dimensional (3D) environments impacts development, wound healing and cancer metastasis and is altered…”
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Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin by Holt, Brian D, Shams, Hengameh, Horst, Travis A, Basu, Saurav, Rape, Andrew D, Wang, Yu-Li, Rohde, Gustavo K, Mofrad, Mohammad R K, Islam, Mohammad F, Dahl, Kris Noel

“…With a range of desirable mechanical and optical properties, single wall carbon nanotubes (SWCNTs) are a promising material for nanobiotechnologies. SWCNTs…”
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Engineering strategies to mimic the glioblastoma microenvironment by Rape, Andrew, Ananthanarayanan, Badriprasad, Kumar, Sanjay

“…Glioblastoma multiforme (GBM) is the most common and deadly brain tumor, with a mean survival time of only 21months. Despite the dramatic improvements in our…”
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Dorsal Adhesion Slows Glioblastoma Migration in Perivascular Mimics by Rape, Andrew, Kumar, Sanjay

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Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substratesElectronic supplementary information (ESI) available: Electronic supplementary movies are captions are provided online. See DOI: 10.1039/c3ib20231c by Booth-Gauthier, Elizabeth A, Du, Vicard, Ghibaudo, Marion, Rape, Andrew D, Dahl, Kris Noel, Ladoux, Benoit

“…Cell migration through tight interstitial spaces in three dimensional (3D) environments impacts development, wound healing and cancer metastasis and is altered…”
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The Regulation of Cellular Traction Forces by Rape, Andrew D

“…In the body, cells are exposed to a diverse array of signaling cascades that compel cells to function properly. In addition to chemical signals, cells are also…”
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Micropatterning cell adhesion on polyacrylamide hydrogels by Zhang, Jian, Guo, Wei-Hui, Rape, Andrew, Wang, Yu-Li

“…Cell shape and substrate rigidity play critical roles in regulating cell behaviors and fate. Controlling cell shape on elastic adhesive materials holds great…”
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