Search Results - "Rapaka, Rekha R."

How do adjuvants enhance immune responses? by Rapaka, Rekha R

“…By altering which peptide antigens are presented to CD4 T cells, adjuvants affect the specificity of the immune response…”
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The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus by Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, Kolls, Jay K, Brown, Gordon D

“…Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data…”
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Using Adjuvants to Drive T Cell Responses for Next-Generation Infectious Disease Vaccines by Rapaka, Rekha R., Cross, Alan S., McArthur, Monica A.

“…Using adjuvants to drive features of T cell responses to vaccine antigens is an important technological challenge in the design of new and improved vaccines…”
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Immune reconstitution inflammatory syndrome associated with pulmonary pathogens by Gopal, Radha, Rapaka, Rekha R, Kolls, Jay K

“…Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response to a variety of pathogens in response to antiretroviral therapy-mediated…”
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Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina by Rapaka, Rekha R, Ricks, David M, Alcorn, John F, Chen, Kong, Khader, Shabaana A, Zheng, Mingquan, Plevy, Scott, Bengtén, Eva, Kolls, Jay K

“…Host defense against opportunistic fungi requires coordination between innate and adaptive immunity for resolution of infection. Antibodies generated in mice…”
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Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type S . Typhi in humans by Booth, Jayaum S, Rapaka, Rekha R, McArthur, Monica A, Fresnay, Stephanie, Darton, Thomas C, Blohmke, Christoph J, Jones, Claire, Waddington, Claire S, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…Despite decades of intense research, our understanding of the correlates of protection against Typhi ( . Typhi) infection and disease remains incomplete. T…”
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Bigger Foot: Kaposi's Sarcoma by Rapaka, Rekha R., MD, PhD, Fischer, Max, MD, Finucane, Thomas E., MD, Mwakingwe, Agnes, MD, PhD

“…A normal CD4+ T cell count does not preclude opportunistic infection in an HIV-positive patient. This point was illustrated by the evaluation of a 33-year-old…”
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Closing the Brief Case: Streptococcus intermedius Brain Abscesses in an Otherwise Healthy Young Man Diagnosed by 16S rRNA Gene Sequencing by Hauser, Naomi, Werzen, Alissa, Rapaka, Rekha R

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The Brief Case: Streptococcus intermedius Brain Abscesses in an Otherwise Healthy Young Man Diagnosed by 16S rRNA Gene Sequencing by Hauser, Naomi, Werzen, Alissa, Rapaka, Rekha R

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Are Some COVID-19 Vaccines Better Than Others? Interpreting and Comparing Estimates of Efficacy in Vaccine Trials by Rapaka, Rekha R, Hammershaimb, Elizabeth A, Neuzil, Kathleen M

“…Abstract Coronavirus disease 2019 (COVID-19) vaccine trials provide valuable insight into the safety and efficacy of vaccines, with individually randomized,…”
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Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella by Rapaka, Rekha R, Wahid, Rezwanul, Fresnay, Stephanie, Booth, Jayaum S, Darton, Thomas C, Jones, Claire, Waddington, Claire S, Levine, Myron M, Pollard, Andrew J, Sztein, Marcelo B

“…Objective There are no vaccines for most of the major invasive Salmonella strains causing severe infection in humans. We evaluated the specificity of adaptive…”
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Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis by MATTILA, Polly E, METZ, Allison E, RAPAKA, Rekha R, BAUER, Lynne D, STEELE, Chad

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An Immunocompromised Woman with a Brain Lesion by Hauser, Naomi, Luethy, Paul M., Rapaka, Rekha R.

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Enhanced Defense against Pneumocystis carinii Mediated by a Novel Dectin-1 Receptor Fc Fusion Protein by Rapaka, Rekha R, Goetzman, Eric S, Zheng, Mingquan, Vockley, Jerry, McKinley, Laura, Kolls, Jay K, Steele, Chad

“…Pneumocystis carinii (PC) pneumonia is a leading opportunistic infection found among HIV-infected individuals worldwide. Although CD4(+) T cell deficiency…”
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Role of Interleukin-23-Dependent Antifungal Immune Responses in Dendritic Cell-Vaccinated Mice by MINGQUAN ZHENG, RAPAKA, Rekha R, YU, Amy C, SHELLITO, Judd E, KOLLS, Jay K

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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CD4 + T Cell Regulation of Antibodies Cross-Reactive with Fungal Cell Wall-Associated Carbohydrates after Pneumocystis murina Infection by Rapaka, Rekha R, Dai, Guixiang, Zheng, Mingquan, Kolls, Jay K

“…pneumonia is a life-threatening opportunistic fungal infection observed in individuals with severe immunodeficiencies, such as AIDS. Molecules with the ability…”
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Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial by Lyke, Kirsten E, Chua, Joel V, Koren, Michael, Friberg, Heather, Gromowski, Gregory D, Rapaka, Rekha R, Waickman, Adam T, Joshi, Sudhaunshu, Strauss, Kathleen, McCracken, Michael K, Gutierrez-Barbosa, Hernando, Shrestha, Biraj, Culbertson, Christopher, Bernal, Paula, De La Barrera, Rafael A, Currier, Jeffrey R, Jarman, Richard G, Edelman, Robert

“…Dengue human infection models (DHIMs) are important tools to down-select dengue vaccine candidates and establish tetravalent efficacy before advanced clinical…”
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A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2 by Paules, Catharine I, Wang, Jing, Tomashek, Kay M, Bonnett, Tyler, Singh, Kanal, Marconi, Vincent C, Davey, Jr, Richard T, Lye, David C, Dodd, Lori E, Yang, Otto O, Benson, Constance A, Deye, Gregory A, Doernberg, Sarah B, Hynes, Noreen A, Grossberg, Robert, Wolfe, Cameron R, Nayak, Seema U, Short, William R, Voell, Jocelyn, Potter, Gail E, Rapaka, Rekha R

“…The ACTT risk profile, which was developed from ACTT-1 (Adaptive COVID-19 Treatment Trial-1), demonstrated that hospitalized patients with COVID-19 in the…”
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Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data by Paules, Catharine I, Gallagher, Shannon K, Rapaka, Rekha R, Davey, Richard T, Doernberg, Sarah B, Grossberg, Robert, Hynes, Noreen A, Ponce, Philip O, Short, William R, Voell, Jocelyn, Wang, Jing, Yang, Otto O, Wolfe, Cameron R, Lye, David C, Dodd, Lori E, Benson, Constance A

“…Abstract This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on…”
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Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial by Potter, Gail E, Bonnett, Tyler, Rubenstein, Kevin, Lindholm, David A, Rapaka, Rekha R, Doernberg, Sarah B, Lye, David C, Mularski, Richard A, Hynes, Noreen A, Kline, Susan, Paules, Catharine I, Wolfe, Cameron R, Frank, Maria G, Rouphael, Nadine G, Deye, Gregory A, Sweeney, Daniel A, Colombo, Rhonda E, Davey, Jr, Richard T, Mehta, Aneesh K, Whitaker, Jennifer A, Castro, Jose G, Amin, Alpesh N, Colombo, Christopher J, Levine, Corri B, Jain, Mamta K, Maves, Ryan C, Marconi, Vincent C, Grossberg, Robert, Hozayen, Sameh, Burgess, Timothy H, Atmar, Robert L, Ganesan, Anuradha, Gomez, Carlos A, Benson, Constance A, Lopez de Castilla, Diego, Ahuja, Neera, George, Sarah L, Nayak, Seema U, Cohen, Stuart H, Lalani, Tahaniyat, Short, William R, Erdmann, Nathaniel, Tomashek, Kay M, Tebas, Pablo

“…The COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear. To evaluate whether recovery and…”
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