labdane diterpene glucoside from the rhizomes of Curcuma mangga

A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxyc...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 68; no. 7; pp. 1090 - 1093
Main Authors:	Abas, F, Lajis, N.H, Shaari, K, Israf, D.A, Stanslas, J, Yusuf, U.K, Raof, S.M
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-07-2005 Glendale, AZ American Society of Pharmacognosy
Subjects:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences chemical reactions chemical structure cultured cells Curcuma Curcuma - chemistry Curcuma mangga curcumanggoside cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor General pharmacology glucosides Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology human health Humans Inhibitory Concentration 50 labdane Malaysia Medical sciences medicinal plants Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant biochemistry plant extracts Plants, Medicinal - chemistry Rhizome - chemistry rhizomes spectral analysis vegetable crops Malaysia Asia Monocotyledones Five membered ring Cytotoxicity Oxygen heterocycle Medicinal plant Angiospermae Rhizome Glycoside Labdane derivatives Tumor cell Food Below ground plant part Human Terpenoid Pharmacognosy Glucoside Lactone Antioxidant Tricyclic compound In vitro Biological activity Cell line Plant origin Diterpene Isolation Flavoring crop Spermatophyta Curcuma Zingiberaceae Structural analysis
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Summary:	A new labdane diterpene glucoside, curcumanggoside (1), together with nine known compounds, including labda-8(17),12-diene-15,16-dial (2), calcaratarin A (3), zerumin B (4), scopoletin, demethoxycurcumin, bisdemethoxycurcumin, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, curcumin, and p-hydroxycinnamic acid, have been isolated from the rhizomes of Curcuma mangga. Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, HSQC, HMBC) NMR techniques. All diarylheptanoids and scopoletin showed significant antioxidant activity. Zerumin B, demethoxycurcumin, bisdemethoxycurcumin, and curcumin also exhibited cytotoxic activity against a panel of five human tumor cell lines.
Bibliography:	ark:/67375/TPS-VP049XJQ-4 istex:71176AB78DC57154B804AEB6BE1D505A7625DC26
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0500171