Search Results - "Rao, Shan"
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Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration
Published in Nanoscale (21-11-2019)“…In elderly people particularly in postmenopausal women, inadequate bone formation by osteoblasts originating from bone marrow mesenchymal stem cells (BMSCs)…”
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Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
Published in Nature communications (18-03-2022)“…Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related…”
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3
Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function
Published in Theranostics (2018)“…The application of blood plasma for soft tissue wound healing is receiving much more attention recently. Exosomes are critical paracrine mediators that can be…”
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4
Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines
Published in Bone research (30-03-2018)“…Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone…”
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The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
Published in Advanced science (01-06-2022)“…Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated degenerative diseases and are strongly correlated with clinical epidemiology…”
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Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8 + T Cells and Macrophages
Published in International journal of nanomedicine (01-01-2021)“…Prostate cancer (PCa) is one of the most common malignancies in males. Despite the success of immunotherapy in many malignant cancers, strategies are still…”
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7
The cancer metabolic reprogramming and immune response
Published in Molecular cancer (05-02-2021)“…The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence…”
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Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy
Published in Theranostics (2021)“…Alzheimer's disease (AD) is currently ranked as the third leading cause of death for eldly people, just behind heart disease and cancer. Autophagy is declined…”
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Ångstrom‐Scale Silver Particles as a Promising Agent for Low‐Toxicity Broad‐Spectrum Potent Anticancer Therapy
Published in Advanced functional materials (01-06-2019)“…Cancer incidence is rising, and the efficacy of current available anticancer agents is limited by severe dose‐limiting toxicities and drug resistance problems…”
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Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
Published in Theranostics (01-01-2020)“…Osteoporosis and osteoporotic fractures severely compromise quality of life in elderly people and lead to early death. Human umbilical cord mesenchymal stromal…”
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Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength
Published in Advanced science (01-05-2021)“…Recently, the gut microbiota (GM) has been shown to be a regulator of bone homeostasis and the mechanisms by which GM modulates bone mass are still being…”
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12
Exosomal miRNAs in tumor microenvironment
Published in Journal of experimental & clinical cancer research (16-04-2020)“…Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune…”
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Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK
Published in Theranostics (01-01-2020)“…Osteosarcoma is a common malignant bone cancer easily to metastasize. Much safer and more efficient strategies are still needed to suppress osteosarcoma growth…”
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14
Fasting before or after wound injury accelerates wound healing through the activation of pro-angiogenic SMOC1 and SCG2
Published in Theranostics (01-01-2020)“…Healing of the chronic diabetic ulceration and large burns remains a clinical challenge. Therapeutic fasting has been shown to improve health. Our study tested…”
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Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3
Published in Autophagy (03-10-2021)“…Senile osteoporosis (OP) is often concomitant with decreased autophagic activity. OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as…”
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Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y
Published in Advanced science (01-12-2021)“…A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age‐ and menopause‐associated bone…”
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The roles of glucose metabolic reprogramming in chemo- and radio-resistance
Published in Journal of experimental & clinical cancer research (23-05-2019)“…Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased…”
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Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG
Published in Bone research (26-06-2019)“…Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells (USCs), which were noninvasively…”
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IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells
Published in Respiratory research (20-09-2017)“…Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC…”
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Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis
Published in Biochimica et biophysica acta. Molecular basis of disease (01-09-2015)“…Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease of unknown cause that typically leads to respiratory failure and death within…”
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