Glaucoma associated with uveitis

Glaucoma associated with uveitis

Raised intraocular pressure is a common and frequently serious complication of anterior uveitis. The milieu of inflammatory cells, the mediators they release, and the corticosteroid therapy used to treat the uveitis can participate in the pathogenesis of uveitic glaucoma. These factors alter the nor...

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Bibliographic Details
Published in:Survey of Ophthalmology Vol. 41; no. 5; pp. 361 - 394
Main Authors: Moorthy, R.A.mana S., Mermoud, A.N.dré, Baerveldt, George, Minckler, Don S., Lee, Paul P., Rao, N.A.rsing A.
Format: Book Review Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-03-1997
Elsevier Science
Subjects:
anterior uveitis
Biological and medical sciences
closed-angle glaucoma
cyclophotocoagulation
Glaucoma - complications
Glaucoma - diagnosis
Glaucoma - therapy
Humans
intermediate uveitis
Medical sciences
Molteno tube
open-angle glaucoma
Ophthalmology
posterior uveitis
trabeculectomy
Uvea diseases
uveitic glaucoma
Uveitis - complications
Uveitis - diagnosis
Uveitis - therapy
open-angle glaucoma
anterior uveitis
Molteno tube
cyclophotocoagulation
trabeculectomy
uveitic glaucoma
closed-angle glaucoma
intermediate uveitis
posterior uveitis
Human
Eye disease
Association
Glaucoma (eye)
Pathogenesis
Anterior uveitis
Uvea disease
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Description
Summary:Raised intraocular pressure is a common and frequently serious complication of anterior uveitis. The milieu of inflammatory cells, the mediators they release, and the corticosteroid therapy used to treat the uveitis can participate in the pathogenesis of uveitic glaucoma. These factors alter the normal anatomic structure of the anterior chamber and angle, influencing aqueous production and outflow. These changes act to disrupt the homeostatic mechanisms of intraocular pressure control. Structural changes in the angle can be acute, such as in secondary angle closure with pupillary block glaucoma, or chronic, such as combined steroid-induced and secondary open angle glaucoma. Management of uveitic glaucoma may be difficult because of the numerous mechanisms involved in its pathogenesis. Diagnostic and therapeutic decisions are guided by careful delineation of the pathophysiology of each individual case. The goal of treatment is to minimize permanent structural alteration of aqueous outflow and to prevent damage to the optic nerve head. This article reviews the pathogenesis of uveitic glaucoma, with specific attention to etiology. Medical and surgical therapies are also discussed, with emphasis on the more recent developments in each category.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0039-6257
1879-3304
DOI:10.1016/S0039-6257(97)00006-4