Search Results - "Rao, Mala V"

Neurofilaments and Neurofilament Proteins in Health and Disease by Yuan, Aidong, Rao, Mala V, Veeranna, Nixon, Ralph A

“…SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L…”
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Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo by Lee, Ju-Hyun, Rao, Mala V., Yang, Dun-Sheng, Stavrides, Philip, Im, Eunju, Pensalfini, Anna, Huo, Chunfeng, Sarkar, Pallabi, Yoshimori, Tamotsu, Nixon, Ralph A.

“…Autophagy-lysosome pathway (ALP) disruption is considered pathogenic in multiple neurodegenerative diseases; however, current methods are inadequate to…”
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The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network by Rao, Mala V, Yuan, Aidong, Campbell, Jabbar, Kumar, Asok, Nixon, Ralph A

“…Newly synthesized neurofilaments or protofilaments are incorporated into a highly stable stationary cytoskeleton network as they are transported along axons…”
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Neurofilaments Form a Highly Stable Stationary Cytoskeleton after Reaching a Critical Level in Axons by Yuan, Aidong, Sasaki, Takahiro, Rao, Mala V, Kumar, Asok, Kanumuri, Vivek, Dunlop, David S, Liem, Ronald K, Nixon, Ralph A

“…The ultrastructural view of the axonal cytoskeleton as an extensively cross-linked network of neurofilaments (NFs) and other cytoskeletal polymers contrasts…”
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The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons by Rao, Mala V, Mohan, Panaiyur S, Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M, Julien, Jean P, Nixon, Ralph A

“…The neurofilament light subunit (NF-L) binds to myosin Va (Myo Va) in neurons but the sites of interaction and functional significance are not clear. We show…”
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Dissociation of Axonal Neurofilament Content from Its Transport Rate by Yuan, Aidong, Hassinger, Linda, Rao, Mala V, Julien, Jean-Pierre, Miller, Christopher C J, Nixon, Ralph A

“…The axonal cytoskeleton of neurofilament (NF) is a long-lived network of fibrous elements believed to be a stationary structure maintained by a small pool of…”
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Calpastatin inhibits motor neuron death and increases survival of hSOD1G93A mice by Rao, Mala V., Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A.

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains…”
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Neurofilaments at a glance by Yuan, Aidong, Rao, Mala V, Veeranna, Nixon, Ralph A

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Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice by Rao, Mala V, Campbell, Jabbar, Palaniappan, Arti, Kumar, Asok, Nixon, Ralph A

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with a poorly understood cause and no effective treatment. Given that calpains…”
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Myosin Va Binding to Neurofilaments Is Essential for Correct Myosin Va Distribution and Transport and Neurofilament Density by Rao, Mala V., Engle, Linda J., Mohan, Panaiyur S., Yuan, Aidong, Qiu, Dike, Cataldo, Anne, Hassinger, Linda, Jacobsen, Stephen, Virginia M-Y. Lee, Andreadis, Athena, Julien, Jean-Pierre, Bridgman, Paul C., Nixon, Ralph A.

“…The identification of molecular motors that modulate the neuronal cytoskeleton has been elusive. Here, we show that a molecular motor protein, myosin Va, is…”
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Autophagy is a novel pathway for neurofilament protein degradation in vivo by Rao, Mala V., Darji, Sandipkumar, Stavrides, Philip H., Goulbourne, Chris N., Kumar, Asok, Yang, Dun-Sheng, Yoo, Lang, Peddy, James, Lee, Ju-Hyun, Yuan, Aidong, Nixon, Ralph A.

“…How macroautophagy/autophagy influences neurofilament (NF) proteins in neurons, a frequent target in neurodegenerative diseases and injury, is not known. NFs…”
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Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice by Diepenbroek, Meike, Casadei, Nicolas, Esmer, Hakan, Saido, Takaomi C, Takano, Jiro, Kahle, Philipp J, Nixon, Ralph A, Rao, Mala V, Melki, Ronald, Pieri, Laura, Helling, Stefan, Marcus, Katrin, Krueger, Rejko, Masliah, Eliezer, Riess, Olaf, Nuber, Silke

“…Lewy bodies, a pathological hallmark of Parkinson's disease (PD), contain aggregated alpha-synuclein (αSyn), which is found in several modified forms and can…”
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Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice by Rao, Mala V, McBrayer, Mary Kate, Campbell, Jabbar, Kumar, Asok, Hashim, Audrey, Sershen, Henry, Stavrides, Philip H, Ohno, Masuo, Hutton, Michael, Nixon, Ralph A

“…Tau pathogenicity in Alzheimer's disease and other tauopathies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau…”
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Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons by Yuan, Aidong, Sasaki, Takahiro, Kumar, Asok, Peterhoff, Corrinne M, Rao, Mala V, Liem, Ronald K, Julien, Jean-Pierre, Nixon, Ralph A

“…Peripherin, a neuronal intermediate filament protein implicated in neurodegenerative disease, coexists with the neurofilament triplet proteins [neurofilament…”
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Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors by Yuan, Aidong, Veeranna, Sershen, Henry, Basavarajappa, Balapal S., Smiley, John F., Hashim, Audrey, Bleiwas, Cynthia, Berg, Martin, Guifoyle, David N., Subbanna, Shivakumar, Darji, Sandipkumar, Kumar, Asok, Rao, Mala V., Wilson, Donald A., Julien, Jean-Pierre, Javitt, Daniel C., Nixon, Ralph A.

“…Neurofilament (NFL) proteins have recently been found to play unique roles in synapses. NFL is known to interact with the GluN1 subunit of N -methyl- d…”
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Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS by Yuan, Aidong, Rao, Mala V, Sasaki, Takahiro, Chen, Yuanxin, Kumar, Asok, Veeranna, Liem, Ronald K H, Eyer, Joel, Peterson, Alan C, Julien, Jean-Pierre, Nixon, Ralph A

“…Alpha-internexin, a neuronal intermediate filament protein implicated in neurodegenerative disease, coexists with the neurofilament (NF) triplet proteins…”
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Phosphorylation of Highly Conserved Neurofilament Medium KSP Repeats Is Not Required for Myelin-Dependent Radial Axonal Growth by Garcia, Michael L, Rao, Mala V, Fujimoto, Jiro, Garcia, Virginia B, Shah, Sameer B, Crum, John, Gotow, Takahiro, Uchiyama, Yasuo, Ellisman, Mark, Calcutt, Nigel A, Cleveland, Don W

“…Neurofilament medium (NF-M) is essential for the acquisition of normal axonal caliber in response to a myelin-dependent "outside-in" trigger for radial axonal…”
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Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice by Morales-Corraliza, Jose, Berger, Jason D, Mazzella, Matthew J, Veeranna, Neubert, Thomas A, Ghiso, Jorge, Rao, Mala V, Staufenbiel, Matthias, Nixon, Ralph A, Mathews, Paul M

“…Abstract We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer's disease (AD)…”
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The Neurofilament Middle Molecular Mass Subunit Carboxyl-Terminal Tail Domains Is Essential for the Radial Growth and Cytoskeletal Architecture of Axons but Not for Regulating Neurofilament Transport Rate by Rao, Mala V., Campbell, Jabbar, Yuan, Aidong, Kumar, Asok, Gotow, Takahiro, Uchiyama, Yasuo, Nixon, Ralph A.

“…The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (NF) subunits, NF heavy (NF-H) and NF medium (NF-M) subunits, have been proposed to…”
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