Search Results - "Rao, Kanury V S"

A non-invasive method for concurrent detection of multiple early-stage cancers in women by Gupta, Ankur, Siddiqui, Zaved, Sagar, Ganga, Rao, Kanury V. S., Saquib, Najmuddin

“…Untargeted serum metabolomics was combined with machine learning-powered data analytics to develop a test for the concurrent detection of multiple cancers in…”
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A non-invasive method for concurrent detection of early-stage women-specific cancers by Gupta, Ankur, Sagar, Ganga, Siddiqui, Zaved, Rao, Kanury V. S., Nayak, Sujata, Saquib, Najmuddin, Anand, Rajat

“…We integrated untargeted serum metabolomics using high-resolution mass spectrometry with data analysis using machine learning algorithms to accurately detect…”
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Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism by Gupta, Nutan, Duggal, Shweta, Kumar, Ajay, Saquib, Najmuddin Mohd, Rao, Kanury V S

“…Signal transduction not only initiates entry into the cell cycle, but also reprograms the cell's metabolism. To control abnormalities in cell proliferation,…”
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Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances by Kumar, Dhiraj, Rao, Kanury V.S.

“…This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis…”
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Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis by Kumar, Dhiraj, Nath, Lekha, Kamal, Md. Azhar, Varshney, Ankur, Jain, Avinash, Singh, Sarman, Rao, Kanury V.S.

“…We performed a genome-wide siRNA screen to identify host factors that regulated pathogen load in human macrophages infected with a virulent strain of…”
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M. tuberculosis Secretory Protein ESAT-6 Induces Metabolic Flux Perturbations to Drive Foamy Macrophage Differentiation by Singh, Varshneya, Kaur, Charanpreet, Chaudhary, Vijay K., Rao, Kanury V. S, Chatterjee, Samrat

“…The Foamy Macrophage (FM) differentiation forms a major component of the host dependent survival axis of M. tuberculosis . The FM which are characterized by…”
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Pathogenicity of Mycobacterium tuberculosis is expressed by regulating metabolic thresholds of the host macrophage by Mehrotra, Parul, Jamwal, Shilpa V, Saquib, Najmuddin, Sinha, Neeraj, Siddiqui, Zaved, Manivel, Venkatasamy, Chatterjee, Samrat, Rao, Kanury V S

“…The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this…”
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Defining the Akt1 interactome and its role in regulating the cell cycle by Duggal, Shweta, Jailkhani, Noor, Midha, Mukul Kumar, Agrawal, Namita, Rao, Kanury V. S., Kumar, Ajay

“…Cell growth and proliferation are two diverse processes yet always linked. Akt1, a serine/threonine kinase, is a multi-functional protein implicated in…”
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Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen by Jayaswal, Shilpi, Kamal, Md Azhar, Dua, Raina, Gupta, Shashank, Majumdar, Tanmay, Das, Gobardhan, Kumar, Dhiraj, Rao, Kanury V S

“…The stable infection of host macrophages by Mycobacterium tuberculosis (Mtb) involves, and depends on, the attenuation of the diverse microbicidal responses…”
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Temporal Profiling of Host Proteome against Different M. tuberculosis Strains Reveals Delayed Epigenetic Orchestration by Babele, Prabhakar, Midha, Mukul K, Rao, Kanury V S, Kumar, Ajay

“…Apart from being preventable and treatable, tuberculosis is the deadliest bacterial disease afflicting humankind owing to its ability to evade host defence…”
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Co-Administration of Anticancer Candidate MK-2206 Enhances the Efficacy of BCG Vaccine Against Mycobacterium tuberculosis in Mice and Guinea Pigs by Bouzeyen, Rania, Chugh, Saurabh, Gosain, Tannu Priya, Barbouche, Mohamed-Ridha, Haoues, Meriam, Rao, Kanury V. S., Essafi, Makram, Singh, Ramandeep

“…The failure of M. bovis BCG to induce long-term protection has been endowed to its inability to escape the phagolysosome, leading to mild activation of CD8 +…”
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Epitope Recognition by Diverse Antibodies Suggests Conformational Convergence in an Antibody Response by Nair, Deepak T, Singh, Kavita, Siddiqui, Zaved, Nayak, Bishnu P, Rao, Kanury V. S, Salunke, Dinakar M

“…Crystal structures of distinct mAbs that recognize a common epitope of a peptide Ag have been determined and analyzed in the unbound and bound forms. These Abs…”
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Mathematical model of mycobacterium-host interaction describes physiology of persistence by Pedruzzi, Gabriele, Rao, Kanury V S, Chatterjee, Samrat

“…Despite extensive studies on the interactions between Mycobacterium tuberculosis (M.tb) and macrophages, the mechanism by which pathogen evades anti-microbial…”
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Regulation of Transcript Elongation through Cooperative and Ordered Recruitment of Cofactors by Sharma, Manish, George, Anuja A., Singh, Badri N., Sahoo, Naresh C., Rao, Kanury V.S.

“…We studied the regulation of murine CD80, a gene whose basal transcriptional status was characterized by the presence of a stalled RNA polymerase II complex on…”
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Activating transcription factor 3 is a positive regulator of human IFNG gene expression by Filén, Sanna, Ylikoski, Emmi, Tripathi, Subhash, West, Anne, Björkman, Mari, Nyström, Joel, Ahlfors, Helena, Coffey, Eleanor, Rao, Kanury V S, Rasool, Omid, Lahesmaa, Riitta

“…IL-12 and IL-18 are essential for Th1 differentiation, whereas the role of IFN-alpha in Th1 development is less understood. In this microarray-based study, we…”
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Extracting Time-dependent Obese-diabetic Specific Networks in Hepatic Proteome Analysis by Midha, Mukul K, Tikoo, Kamiya, Sinha, Neeraj, Kaur, Simarjeet, Verma, Hirdya N, Rao, Kanury V. S, Chatterjee, Samrat, Manivel, Venkatasamy

“…Molecular mechanism governing biological processes leading to dietary obesity and diabetes are largely unknown. Here we study the liver proteome differentially…”
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THP1 proteomics in response to mycobacterium tuberculosis infection by Kumar, Ajay, Midha, Mukul K., Rao, Kanury VS

“…Temporal data on how the mycobacterium infection establishes itself inside the host cell is not available. We differentiated human THP1 cell line with PMA and…”
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Integration of a Phosphatase Cascade with the Mitogen-activated Protein Kinase Pathway Provides for a Novel Signal Processing Function by Chaudhri, Virendra K., Kumar, Dhiraj, Misra, Manjari, Dua, Raina, Rao, Kanury V.S.

“…We mathematically modeled the receptor-dependent mitogen-activated protein kinase (MAPK) signaling by incorporating the regulation through cellular…”
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PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation by Tahvanainen, Johanna, Kallonen, Teemu, Lähteenmäki, Hanna, Heiskanen, Kaisa M., Westermarck, Jukka, Rao, Kanury V.S., Lahesmaa, Riitta

“…The identification of novel factors regulating human T helper (Th)–cell differentiation into functionally distinct Th1 and Th2 subsets is important for…”
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Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype by Singh, Varshneya, Jamwal, Shilpa, Jain, Ritu, Verma, Priyanka, Gokhale, Rajesh, Rao, Kanury V.S.

“…Upon infection, Mycobacterium tuberculosis (Mtb) metabolically alters the macrophage to create a niche that is ideally suited to its persistent lifestyle…”
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