Search Results - "Rao, H.B.D. Prasada"
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Impeding DNA Break Repair Enables Oocyte Quality Control
Published in Molecular cell (18-10-2018)“…Oocyte quality control culls eggs with defects in meiosis. In mouse, oocyte death can be triggered by defects in chromosome synapsis and recombination, which…”
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Glutathione peroxidase (GPX1) - Selenocysteine metabolism preserves the follicular fluid's (FF) redox homeostasis via IGF-1- NMD cascade in follicular ovarian cysts (FOCs)
Published in Biochimica et biophysica acta. Molecular basis of disease (01-08-2024)“…Follicular ovarian cysts (FOCs) are characterized by follicles in the ovaries that are >20 mm in diameter and persist for >10 days without the corpus luteum,…”
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A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination
Published in Science (American Association for the Advancement of Science) (27-01-2017)“…Meiosis produces haploid gametes through a succession of chromosomal events, including pairing, synapsis, and recombination. Mechanisms that orchestrate these…”
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Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Published in Molecular cell (02-04-2020)“…Crossover recombination is essential for accurate chromosome segregation during meiosis. The MutSγ complex, Msh4-Msh5, facilitates crossing over by binding and…”
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Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination
Published in Nature genetics (01-02-2014)“…Neil Hunter and colleagues show that the HEI10 ubiquitin ligase regulates meiotic recombination by limiting the colocalization of RNF212 and MSH4-MSH5 to…”
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