Search Results - "Rao, Antara"

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease by Zalocusky, Kelly A., Najm, Ramsey, Taubes, Alice L., Hao, Yanxia, Yoon, Seo Yeon, Koutsodendris, Nicole, Nelson, Maxine R., Rao, Antara, Bennett, David A., Bant, Jason, Amornkul, Dah-eun J., Xu, Qin, An, Alice, Cisne-Thomson, Olga, Huang, Yadong

“…Selective neurodegeneration is a critical causal factor in Alzheimer’s disease (AD); however, the mechanisms that lead some neurons to perish, whereas others…”
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Structure of a single whisker representation in layer 2 of mouse somatosensory cortex by Clancy, Kelly B, Schnepel, Philipp, Rao, Antara T, Feldman, Daniel E

“…Layer (L)2 is a major output of primary sensory cortex that exhibits very sparse spiking, but the structure of sensory representation in L2 is not well…”
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Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons by Adil, Maroof M, Vazin, Tandis, Ananthanarayanan, Badriprasad, Rodrigues, Gonçalo M.C, Rao, Antara T, Kulkarni, Rishikesh U, Miller, Evan W, Kumar, Sanjay, Schaffer, David V

“…Abstract Cell replacement therapies have broad biomedical potential; however, low cell survival and poor functional integration post-transplantation are major…”
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Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform by Adil, Maroof M., Rodrigues, Gonçalo M. C., Kulkarni, Rishikesh U., Rao, Antara T., Chernavsky, Nicole E., Miller, Evan W., Schaffer, David V.

“…Pluripotent stem cells (PSCs) have major potential as an unlimited source of functional cells for many biomedical applications; however, the development of…”
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In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons by Najm, Ramsey, Zalocusky, Kelly A., Zilberter, Misha, Yoon, Seo Yeon, Hao, Yanxia, Koutsodendris, Nicole, Nelson, Maxine, Rao, Antara, Taubes, Alice, Jones, Emily A., Huang, Yadong

“…Despite its clear impact on Alzheimer’s disease (AD) risk, apolipoprotein (apo) E4’s contributions to AD etiology remain poorly understood. Progress in…”
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hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model by Adil, Maroof M., Gaj, Thomas, Rao, Antara T., Kulkarni, Rishikesh U., Fuentes, Christina M., Ramadoss, Gokul N., Ekman, Freja K., Miller, Evan W., Schaffer, David V.

“…Huntington disease (HD) is an inherited, progressive neurological disorder characterized by degenerating striatal medium spiny neurons (MSNs). One promising…”
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Dopaminergic Neurons Transplanted Using Cell‐Instructive Biomaterials Alleviate Parkinsonism in Rodents by Adil, Maroof M., Rao, Antara T., Ramadoss, Gokul N., Chernavsky, Nicole E., Kulkarni, Rishikesh U., Miller, Evan W., Kumar, Sanjay, Schaffer, David V.

“…Cell replacement therapy (CRT) is a promising treatment for degenerative disorders, such as Parkinson's disease (PD). However, CRT is in general hindered by…”
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Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System by Rodrigues, Gonçalo M.C., Gaj, Thomas, Adil, Maroof M., Wahba, Joyce, Rao, Antara T., Lorbeer, Franziska K., Kulkarni, Rishi U., Diogo, Maria Margarida, Cabral, Joaquim M.S., Miller, Evan W., Hockemeyer, Dirk, Schaffer, David V.

“…Oligodendrocyte precursor cells (OPCs) offer considerable potential for the treatment of demyelinating diseases and injuries of the CNS. However, generating…”
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Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms by Koutsodendris, Nicole, Nelson, Maxine R, Rao, Antara, Huang, Yadong

“…Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves dysregulation of many cellular and molecular processes. It is notoriously…”
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Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer’s Disease by Najm, Ramsey, Rao, Antara, Huang, Yadong

“…Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer’s disease (AD) is essential for unravelling its role in pathogenesis. In this…”
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Study the Roles of Apoe and Microglia in Alzheimer's Disease Using a Chimeric Mouse Model by Rao, Antara

“…Despite strong evidence supporting the involvement of both apolipoprotein E4 (APOE4) and microglia in Alzheimer’s Disease (AD) pathogenesis, the effects of…”
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation by Nelson, Maxine R., Liu, Peng, Agrawal, Ayushi, Yip, Oscar, Blumenfeld, Jessica, Traglia, Michela, Kim, Min Joo, Koutsodendris, Nicole, Rao, Antara, Grone, Brian, Hao, Yanxia, Yoon, Seo Yeon, Xu, Qin, De Leon, Samuel, Choenyi, Tenzing, Thomas, Reuben, Lopera, Francisco, Quiroz, Yakeel T., Arboleda-Velasquez, Joseph F., Reiman, Eric M., Mahley, Robert W., Huang, Yadong

“…Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), leading to earlier age of clinical onset and…”
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Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits by Koutsodendris, Nicole, Blumenfeld, Jessica, Agrawal, Ayushi, Traglia, Michela, Grone, Brian, Zilberter, Misha, Yip, Oscar, Rao, Antara, Nelson, Maxine R, Hao, Yanxia, Thomas, Reuben, Yoon, Seo Yeon, Arriola, Patrick, Huang, Yadong

“…Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer's disease (AD). Conditions of stress or injury induce APOE…”
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APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release by Koutsodendris, Nicole, Blumenfeld, Jessica, Agrawal, Ayushi, Traglia, Michela, Yip, Oscar, Rao, Antara, Kim, Min Joo, Nelson, Maxine R., Wang, Yung-Hua, Grone, Brian, Hao, Yanxia, Thomas, Reuben, Zilberter, Misha, Yoon, Seo Yeon, Arriola, Patrick, Huang, Yadong

“…Apolipoprotein E4 (APOE4) is an important driver of Tau pathology, gliosis, and degeneration in Alzheimer’s disease (AD). Still, the mechanisms underlying…”
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Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1 by Aery Jones, Emily A., Rao, Antara, Zilberter, Misha, Djukic, Biljana, Bant, Jason S., Gillespie, Anna K., Koutsodendris, Nicole, Nelson, Maxine, Yoon, Seo Yeon, Huang, Ky, Yuan, Heidi, Gill, Theodore M., Huang, Yadong, Frank, Loren M.

“…Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes,…”
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