Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway

Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway

The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria...

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Bibliographic Details
Published in:BMC infectious diseases Vol. 21; no. 1; pp. 1 - 562
Main Authors: Eldholm, Vegard, Ranning, Janne O, Mengshoel, Anne Torunn, Arnesen, Trude
Format: Journal Article
Language:English
Published: London BioMed Central Ltd 12-06-2021
BioMed Central
BMC
Subjects:
Causes of
Clinical isolates
Contact tracing
Disease
Disease transmission
Distribution
Gene sequencing
Genomes
Imports
Infections
Infectious diseases
Low-incidence country
Mycobacterial infections
Mycobacterium
Mycobacterium africanum
Mycobacterium orygis
Patients
Phylogenetics
Phylogeny
Transmission
Tuberculosis
Whole-genome sequencing
Norway
United States > US
West Africa
Horn of Africa
East Africa
South Asia
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Summary:The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria (NRL) and identified as MAF in Norway, in the period 2010-2020. Phylogenetic analyses were performed. The analyses indicated several imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis. Most MAF cases in Norway are the result of import, but transmission is occurring within Norway.
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ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-021-06269-3