Search Results - "Rankin, Catharine"

High-throughput behavioral analysis in C. elegans by Swierczek, Nicholas A, Giles, Andrew C, Rankin, Catharine H, Kerr, Rex A

“…The Multi-Worm Tracker permits real-time, high-throughput, quantitative analysis of behavior in Caenorhabditis elegans . It should enable screens for genes…”
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A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration by Parvand, Mahraz, Liang, Joseph J H, Bozorgmehr, Tahereh, Born, Dawson, Luna Cortes, Alvaro, Rankin, Catharine H

“…Mutations in the presenilin (PS) genes are a predominant cause of familial Alzheimer's disease (fAD). An ortholog of PS in the genetic model organism…”
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An Elegant Mind: Learning and Memory in "Caenorhabditis elegans" by Ardiel, Evan L, Rankin, Catharine H

“…This article reviews the literature on learning and memory in the soil-dwelling nematode "Caenorhabditis elegans." Paradigms include nonassociative learning,…”
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A review of transgenerational epigenetics for RNAi, longevity, germline maintenance and olfactory imprinting in Caenorhabditis elegans by Rankin, Catharine H

“…Inheritance of acquired characteristics without changes in DNA sequence has been called transgenerational epigenetics. This review looks at studies that used…”
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Introduction to the presidential symposium at the International Congress of Neuroethology, ICN 2018 in Brisbane, Australia by Rankin, Catharine H.

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Is There a Shared Etiology of Olfactory Impairments in Normal Aging and Neurodegenerative Disease? by Parvand, Mahraz, Rankin, Catharine H

“…As we age, our olfactory function declines. In addition to occurring in normal aging, more rapid decrement of olfactory decline has been associated with…”
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Habituation is altered in neuropsychiatric disorders—A comprehensive review with recommendations for experimental design and analysis by McDiarmid, Troy A., Bernardos, Aram C., Rankin, Catharine H.

“…•Abnormalities in the simplest form of learning, habituation, have been reported in a variety of etiologically diverse neuropsychiatric disorders.•Habituation…”
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Habituation Is More Than Learning to Ignore: Multiple Mechanisms Serve to Facilitate Shifts in Behavioral Strategy by McDiarmid, Troy A., Yu, Alex J., Rankin, Catharine H.

“…Recent work indicates that there are distinct response habituation mechanisms that can be recruited by different stimulation rates and that can underlie…”
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Peel-1 negative selection promotes screening-free CRISPR-Cas9 genome editing in Caenorhabditis elegans by McDiarmid, Troy A, Au, Vinci, Moerman, Donald G, Rankin, Catharine H

“…Improved genome engineering methods that enable automation of large and precise edits are essential for systematic investigations of genome function. We…”
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Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegans by Kindt, Katie S., Quast, Kathleen B., Giles, Andrew C., De, Subhajyoti, Hendrey, Dan, Nicastro, Ian, Rankin, Catharine H., Schafer, William R.

“…Dopamine has been implicated in the modulation of diverse forms of behavioral plasticity, including appetitive learning and addiction. An important challenge…”
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But can they learn? My accidental discovery of learning and memory in C. elegans by Rankin, Catharine H.

“…I did not set out to study C. elegans. My undergraduate and graduate training was in Psychology. My postdoctoral work involved studying learning and memory in…”
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Neurobiology: From genome and connectome to understanding behavior by Yu, Alex J., Rankin, Catharine H.

“…Many forms of synaptic plasticity are mediated by changes in the abundance, density, and expression levels of postsynaptic ionotropic receptors. A new study…”
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Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation by McDiarmid, Troy A., Belmadani, Manuel, Liang, Joseph, Meili, Fabian, Mathews, Eleanor A., Mullen, Gregory P., Hendi, Ardalan, Wong, Wan-Rong, Rand, James B., Mizumoto, Kota, Haas, Kurt, Pavlidis, Paul, Rankin, Catharine H.

“…A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown…”
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The role of neuropeptides in learning: Insights from C. elegans by De Fruyt, Nathan, Yu, Alex J., Rankin, Catharine H., Beets, Isabel, Chew, Yee Lian

“…[Display omitted] Learning is critical for survival as it provides the capacity to adapt to a changing environment. At the molecular and cellular level,…”
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Habituation revisited: An updated and revised description of the behavioral characteristics of habituation by Rankin, Catharine H., Abrams, Thomas, Barry, Robert J., Bhatnagar, Seema, Clayton, David F., Colombo, John, Coppola, Gianluca, Geyer, Mark A., Glanzman, David L., Marsland, Stephen, McSweeney, Frances K., Wilson, Donald A., Wu, Chun-Fang, Thompson, Richard F.

“…The most commonly cited descriptions of the behavioral characteristics of habituation come from two papers published almost 40 years ago [Groves, P. M., &…”
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wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background by Feresten, Abigail H, Bhat, Jaffar M, Yu, Alex J, Zapf, Richard, Rankin, Catharine H, Hutter, Harald

“…Abstract During nervous system development, neurons send out axons, which must navigate large distances to reach synaptic targets. Axons grow out sequentially…”
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Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders by Kepler, Lexis D., McDiarmid, Troy A., Rankin, Catharine H.

“…•Habituation impairments are present in multiple neurodevelopmental disorders.•Habituation and many risk genes are conserved in high-throughput model…”
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Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans by Kepler, Lexis D, McDiarmid, Troy A, Rankin, Catharine H

“…Recent studies have indicated that some phenotypes caused by decreased function of select neurodevelopmental disorder (NDD) risk genes can be reversed by…”
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Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction by Post, Kathryn L., Belmadani, Manuel, Ganguly, Payel, Meili, Fabian, Dingwall, Riki, McDiarmid, Troy A., Meyers, Warren M., Herrington, Caitlin, Young, Barry P., Callaghan, Daniel B., Rogic, Sanja, Edwards, Matthew, Niciforovic, Ana, Cau, Alessandro, Rankin, Catharine H., O’Connor, Timothy P., Bamji, Shernaz X., Loewen, Christopher J. R., Allan, Douglas W., Pavlidis, Paul, Haas, Kurt

“…Functional variomics provides the foundation for personalized medicine by linking genetic variation to disease expression, outcome and treatment, yet its…”
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Habituation mechanisms and their importance for cognitive function by Schmid, Susanne, Wilson, Donald A, Rankin, Catharine H

“…(2013b) investigated the role of a voltage-and calcium activated potassium channel (BK channel) in short- and long-term habituation of an elicited behavior…”
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