Search Results - "Ranjan Panda, Samir"

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease by Ahmed, Sahabuddin, Kwatra, Mohit, Ranjan Panda, Samir, Murty, U.S.N, Naidu, V.G.M.

“…Fig. A schematic diagram representing the signaling cascade involved in NLRP3 inflammasome activation in microglial cells through LPS priming (Signal 1) and…”
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AKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma by Syamprasad, NP, Jain, Siddhi, Rajdev, Bishal, Panda, Samir Ranjan, Kumar, Gangasani Jagadeesh, Shaik, Khaja Moinuddin, Shantanu, P.A., Challa, Veerabhadra Swamy, Jorvekar, Sachin B., Borkar, Roshan M., Vaidya, Jayathirtha Rao, Tripathi, Dinesh Mani, Naidu, V.G.M.

“…The mechanism behind the progressive pathological alteration in metabolic dysfunction-associated steatotic liver disease/steatohepatitis…”
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Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling by Kwatra, Mohit, Ahmed, Sahabuddin, Gawali, Basveshwar, Panda, Samir Ranjan, Naidu, VGM

“…Stress and lipopolysaccharide (LPS) animal models are used for screening antidepressants and anxiolytic drugs. However, the lacunae for their combination…”
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Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson’s Disease by Ahmed, Sahabuddin, Panda, Samir Ranjan, Kwatra, Mohit, Sahu, Bidya Dhar, Naidu, VGM

“…NLRP3 activation plays a key role in the initiation and progression of a variety of neurodegenerative diseases. However, understanding the molecular mechanisms…”
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Neurobehavioral Analysis to Assess Olfactory and Motor Dysfunction in Parkinson's Disease by Panda, Samir Ranjan, Panja, Pallabi, Soni, Ujjawal, Naidu, V G M

“…Parkinson's disease (PD) is the second most common neurodegenerative condition, primarily affecting dopaminergic neurons. It is defined by motor impairments,…”
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Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death by Ahmed, Sahabuddin, Kwatra, Mohit, Gawali, Basveshwar, Panda, Samir Ranjan, Naidu, V. G. M.

“…Striatal neurons depends on an afferent supply of brain-derived neurotrophic factor-(BDNF) that explicitly interacts with tropomyosin receptor kinase B (TrkB)…”
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Phytochemistry and polypharmacology of cleome species: A comprehensive Ethnopharmacological review of the medicinal plants by Chand, Jagdish, Panda, Samir Ranjan, Jain, Siddhi, Murty, U.S.N., Das, Archana Moni, Kumar, Gangasani Jagadeesh, Naidu, V.G.M.

“…Cleome species in particular (C. gynandra Linn, C. viscosa Linn, C. rutidosperma DC, C. felina Linn.), commonly known as spider flowers, belong to the genus of…”
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Loganic acid protects against ulcerative colitis by inhibiting TLR4/NF-κB mediated inflammation and activating the SIRT1/Nrf2 anti-oxidant responses in-vitro and in-vivo by Prakash, Arun N., Prasad, Neethu, Puppala, Eswara Rao, Panda, Samir Ranjan, Jain, Siddhi, Ravichandiran, V., Singh, Meenakshi, Naidu, V.G.M.

“…[Display omitted] •LA attenuates LPS induced NF-κB inflammation in RAW 264.7 and Caco-2 cells.•LA alleviates DSS-induced inflammatory cytokines and chemokines…”
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Pivotal role of AKR1B1 in pathogenesis of colitis associated colorectal carcinogenesis by Syamprasad, N.P., Rajdev, Bishal, Jain, Siddhi, Panda, Samir Ranjan, Puppala, Eswara Rao, Chaudhari, Pradip, Vaidya, Jayathirtha Rao, Kumar, Gangasani Jagadeesh, Naidu, V.G.M.

“…[Display omitted] •AKR1B1 mediates colitis-associated colon carcinogenesis in mice.•AKR1B1 inhibition prevents TNF-α mediated NF-κB activation and H2O2 induced…”
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Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation by Kwatra, Mohit, Ahmed, Sahabuddin, Gangipangi, Vijaya Kumar, Panda, Samir Ranjan, Gupta, Nitika, Shantanu, P.A., Gawali, Basveshwar, Naidu, V.G.M.

“…Major depressive disorder (MDD) is the foremost leading psychiatric illness prevailing around the globe. It usually exists along with anxiety and other…”
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Pharmacokinetic, Protein Binding, and Tissue Distribution Investigations of Viloxazine Enantiomers in Rat Plasma by HPLC–MS/MS Using Polysaccharide-Based Immobilized Chiral Column: A Preclinical Approach to Possible Chiral Switch by Rayala, V. V. S. Prasanna Kumari, Panda, Samir Ranjan, Radhakrishnanand, P.

“…Viloxazine has a long past of medical use to treat depression in Europe, and it has lately been repurposed for the treatment of attention-deficit/hyperactivity…”
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Ambient particulate matter (PM2.5) exposure contributes to neurodegeneration through the microbiome-gut-brain axis: Therapeutic role of melatonin by Panda, Samir Ranjan, Chaudhari, Vishal Balu, Ahmed, Sahabuddin, Kwatra, Mohit, Jala, Aishwarya, Ponneganti, Srikanth, Pawar, Sharad D., Borkar, Roshan M., Sharma, Pawan, Naidu, V.G.M.

“…Exposure to ambient particulate matter (PM2.5) has been shown to disturb the gut microbiome homeostasis and cause initiation of neuroinflammation and…”
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Discovery of novel substituted (Z)-N′-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease by Shankar, Gauri, Praveen Kumar, C., Yadav, Meenu, Ghosh, Aparajita, Panda, Samir Ranjan, Banerjee, Aritra, Tiwari, Ankit, Rai, Sanskriti, Kumar, Saroj, Garg, Prabha, Naidu, V.G.M., Kulkarni, Onkar, Modi, Gyan

“…Alzheimer's disease (AD) is a neurodegenerative disorder marked by significant loss of central cholinergic neurons. This progressive deterioration leads to…”
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AKR1B1 inhibition using NARI-29-an Epalrestat analogue-alleviates Doxorubicin-induced cardiotoxicity via modulating Calcium/CaMKII/MuRF-1 axis by Syamprasad, N.P., Jain, Siddhi, Rajdev, Bishal, Panda, Samir Ranjan, Gangasani, Jagadeesh Kumar, Challa, Veerabhadra Swamy, Vaidya, Jayathirtha Rao, Kundu, Gopal C., Naidu, V.G.M.

“…The clinical use of doxorubicin (Dox) is narrowed due to its carbonyl reduction to doxorubicinol (Doxol) implicating resistance and cardiotoxicity. Hence, in…”
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Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease by Singh, Gourav, Kumar, Sunil, Panda, Samir Ranjan, Kumar, Prabhat, Rai, Sanskriti, Verma, Himanshu, Singh, Yash Pal, Kumar, Saroj, Srikrishna, Saripella, Naidu, V.G.M., Modi, Gyan

“…Alzheimer’s disease (AD) is the most prevalent cause of dementia and is characterized by low levels of acetyl and butyrylcholine, increased oxidative stress,…”
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Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer’s Disease by Singh, Gourav, Shankar, Gauri, Panda, Samir Ranjan, Kumar, Sunil, Rai, Sanskriti, Verma, Himanshu, Kumar, Prabhat, Nayak, Prasanta Kumar, Naidu, V.G.M., Srikrishna, Saripella, Kumar, Saroj, Modi, Gyan

“…Alzheimer’s disease (AD) is the most common cause of dementia, which arises due to low levels of acetyl and butyrylcholines, an increase in oxidative stress,…”
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