Search Results - "Ranjan, Swarnim"

Strategies for high‐concentration drug substance manufacturing to facilitate subcutaneous administration: A review by Holstein, Melissa, Hung, Jessica, Feroz, Hasin, Ranjan, Swarnim, Du, Cheng, Ghose, Sanchayita, Li, Zheng Jian

“…To achieve the high protein concentrations required for subcutaneous administration of biologic therapeutics, numerous manufacturing process challenges are…”
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Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes by Billups, Matthew, Minervini, Mirko, Holstein, Melissa, Feroz, Hasin, Ranjan, Swarnim, Hung, Jessica, Bao, Haiying, Li, Zheng Jian, Ghose, Sanchayita, Zydney, Andrew L.

“…Virus removal filtration is a critical step in the manufacture of monoclonal antibody products, providing a robust size‐based removal of both enveloped and…”
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Investigation of cathepsin D–mAb interactions using a combined experimental and computational tool set by Ranjan, Swarnim, Chung, Wai Keen, Hofele, Romina, Heidbrink Thompson, Jenny, Bee, Jared, Zhang, Limin, Robbins, David, Cramer, Steven M.

“…Cathepsin D has been identified as a challenge to remove in downstream bioprocessing of monoclonal antibodies (mAbs) due to interactions with some mAbs. This…”
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Implementation of an experimental and computational tool set to study protein‐mAb interactions by Ranjan, Swarnim, Chung, Wai Keen, Zhu, Min, Robbins, David, Cramer, Steven M.

“…This work focused on the development of a combined experimental and computational tool set to study protein‐mAb interactions. A model protein library was first…”
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Short-Course Therapy for Pediatric Urinary Tract Infections: Pediatrician's Viewpoint by Swarnim, Swarnim

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Short-Course Therapy for Pediatric Urinary Tract Infections by Chawla, Deepak, Krishnasamy, Sudarsan, Ranjan, Swarnim

“…Summary The SCOUT study is a multicenter, placebo-controlled, double-blind randomized controlled trial conducted to evaluate if a shorter 5-day course of…”
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Antibody retention by virus filtration membranes: Polarization and sieving effects by Billups, Matthew, Minervini, Mirko, Holstein, Melissa, Feroz, Hasin, Ranjan, Swarnim, Hung, Jessica, Bao, Haiying, Ghose, Sanchayita, Li, Zheng Jian, Zydney, Andrew L.

“…Virus filtration is a key component of the overall virus clearance strategy in the production of monoclonal antibodies. These virus filtration membranes also…”
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The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes by Billups, Matthew, Minervini, Mirko, Holstein, Melissa, Feroz, Hasin, Ranjan, Swarnim, Hung, Jessica, Zydney, Andrew L.

“…The removal of viruses by filtration is a critical unit operation to ensure the overall safety of monoclonal antibody (mAb) products. Many mAbs show very low…”
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Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity by Ladiwala, Ali Reza A., Litt, Jeffrey, Kane, Ravi S., Aucoin, Darryl S., Smith, Steven O., Ranjan, Swarnim, Davis, Judianne, Van Nostrand, William E., Tessier, Peter M.

“…Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid…”
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Protein Binding Kinetics in Multimodal Systems: Implications for Protein Separations by Srinivasan, Kartik, Sorci, Mirco, Sejergaard, Lars, Ranjan, Swarnim, Belfort, Georges, Cramer, Steven M

“…In this work, quartz crystal microbalance with dissipation (QCM-D) was employed to study the kinetic processes involved in the interaction of proteins with…”
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Virus inactivation at moderately low pH varies with virus and buffer properties by Joshi, Pratik U., Meingast, Christa L., Xu, Xuankuo, Holstein, Melissa, Feroz, Hasin, Ranjan, Swarnim, Ghose, Sanchayita, Li, Zheng Jian, Heldt, Caryn L.

“…Background Virus inactivation is a critical operation in therapeutic protein manufacturing. Low pH buffers are a widely used strategy to ensure robust…”
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Physiochemical properties of enveloped viruses and arginine dictate inactivation by Meingast, Christa L., Joshi, Pratik U., Turpeinen, Dylan G., Xu, Xuankuo, Holstein, Melissa, Feroz, Hasin, Ranjan, Swarnim, Ghose, Sanchayita, Li, Zheng Jian, Heldt, Caryn L.

“…Background Therapeutic protein manufacturing would benefit by having an arsenal of ways to inactivate viruses. There have been many publications on the virus…”
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Biophysical Investigation for Elucidating Complex Chromatographic Behavior in Downstream Processing of Biologics by Ranjan, Swarnim

“…Monoclonal antibodies (mAbs) have emerged as highly important protein therapeutics in the recent years. In spite of targeting a wide array of targets, mAbs…”
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