In vivo antibacterial activity and pharmacological properties of the membrane-active glycopeptide antibiotic YV11455

Highlights • Studies were performed to assess the efficacy of the membrane-active glycopeptide YV11455. • YV11455 displayed excellent activity against various drug-resistant clinical isolates. • YV11455 showed 270-fold and 136-fold greater activity than vancomycin against vancomycin-resistant Staphy...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 45; no. 6; pp. 627 - 634
Main Authors:	Yarlagadda, Venkateswarlu, Konai, Mohini M, Manjunath, Goutham B, Prakash, Relekar G, Mani, Bhuvana, Paramanandham, Krishnamoorthy, Ranjan, Shome B, Ravikumar, Raju, Chakraborty, Subhankari P, Roy, Somenath, Haldar, Jayanta
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2015
Subjects:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibiotic resistance Bacterial Load Disease Models, Animal Drug-Related Side Effects and Adverse Reactions - pathology Female Glycopeptide antibiotics Glycopeptides - administration & dosage Glycopeptides - adverse effects Glycopeptides - pharmacokinetics Glycopeptides - pharmacology In vivo efficacy Infectious Disease Kidney Function Tests Liver Function Tests Membrane-active antibiotic Methicillin-Resistant Staphylococcus aureus - drug effects Mice Muscles - microbiology Pharmacological properties Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Vancomycin - administration & dosage Vancomycin - adverse effects Vancomycin - pharmacokinetics Vancomycin - pharmacology Vancomycin-resistant bacteria Membrane-active antibiotic In vivo efficacy Vancomycin-resistant bacteria Antibiotic resistance Pharmacological properties Glycopeptide antibiotics
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Summary:	Highlights • Studies were performed to assess the efficacy of the membrane-active glycopeptide YV11455. • YV11455 displayed excellent activity against various drug-resistant clinical isolates. • YV11455 showed 270-fold and 136-fold greater activity than vancomycin against vancomycin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. • Compared with vancomycin, YV11455 show excellent efficacy in a neutropenic mouse thigh infection model against meticillin-resistant S. aureus. • YV11455 showed improved pharmacological properties over vancomycin, with no toxicity.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.02.013