Search Results - "Rani, Aradhana"

RAR-related orphan receptor alpha and the staggerer mice: a fine molecular story by Rani, Aradhana

“…The retinoic acid-related orphan receptor alpha (RORα) protein first came into the limelight due to a set of staggerer mice, discovered at the Jackson…”
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Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy by Rani, Aradhana, Stebbing, Justin, Giamas, Georgios, Murphy, John

“…The importance and role of the estrogen receptor (ER) pathway has been well-documented in both breast cancer (BC) development and progression. The treatment of…”
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IL-15 Upregulates Telomerase Expression and Potently Increases Proliferative Capacity of NK, NKT-Like, and CD8 T Cells by Watkinson, Fiona, Nayar, Sandeep Krishan, Rani, Aradhana, Sakellariou, Christina A, Elhage, Oussama, Papaevangelou, Efthymia, Dasgupta, Prokar, Galustian, Christine

“…Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural killer (NK) cell populations, and therefore has potential for…”
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FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells by Rani, Aradhana, Greenlaw, Roseanna, Runglall, Manohursingh, Jurcevic, Stipo, John, Susan

“…Signal transducers and activators of transcription 5(STAT5) are cytokine induced signaling proteins, which regulate key immunological processes, such as…”
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Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer by Ribas, Ricardo, Pancholi, Sunil, Rani, Aradhana, Schuster, Eugene, Guest, Stephanie K, Nikitorowicz-Buniak, Joanna, Simigdala, Nikiana, Thornhill, Allan, Avogadri-Connors, Francesca, Cutler, Jr, Richard E, Lalani, Alshad S, Dowsett, Mitch, Johnston, Stephen R, Martin, Lesley-Ann

“…Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER ) breast cancer (BC). However, resistance remains problematic…”
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Prostate Cancer: The Role of Inflammation and Chemokines by Rani, Aradhana, Dasgupta, Prokar, Murphy, John J

“…Prostate cancer (PC) is a leading cause of death in men. Inflammation is one of the initiating processes whereby cells are trafficked into the tumor…”
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STAT5 in Cancer and Immunity by Rani, Aradhana, Murphy, John J

“…Signal transducers and activators of transcription 5 (STAT5a and STAT5b) are highly homologous proteins that are encoded by 2 separate genes and are activated…”
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Prostate Cancer by Rani, Aradhana, Dasgupta, Prokar, Murphy, John J.

“…Prostate cancer (PC) is a leading cause of death in men. Inflammation is one of the initiating processes whereby cells are trafficked into the tumor…”
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Prostate Cancer by Rani, Aradhana, Dasgupta, Prokar, Murphy, John J.

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HES1 in immunity and cancer by Rani, Aradhana, Greenlaw, Roseanna, Smith, Richard A, Galustian, Christine

“…Highlights • HES1 is regulated by the NOTCH signalling pathway as well as the wnt and hedgehog pathways. • HES1 plays an important role in T cell development…”
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155: STAT5 regulation of TOX: Its dependence on IL-2 and role in cancer by Rani, Aradhana, Murphy, John, Jurcevic, Stipo

“…The Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway represents a rapid membrane to nucleus signaling system used by cytokines,…”
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155 by Rani, Aradhana, Murphy, John, Jurcevic, Stipo

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AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo by Ribas, Ricardo, Pancholi, Sunil, Guest, Stephanie K, Marangoni, Elisabetta, Gao, Qiong, Thuleau, Aurélie, Simigdala, Nikiana, Polanska, Urszula M, Campbell, Hayley, Rani, Aradhana, Liccardi, Gianmaria, Johnston, Stephen, Davies, Barry R, Dowsett, Mitch, Martin, Lesley-Ann

“…PI3K/AKT/mTOR signaling plays an important role in breast cancer. Its interaction with estrogen receptor (ER) signaling becomes more complex and interdependent…”
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ID: 210: The Notch target HES1, is a STAT5 target gene which could have implications in cancer therapeutics by Rani, Aradhana, Greenlaw, Roseanna, Galustian, Christine, Murphy, John

“…The JAK-STAT pathway represents the principal signaling mode used by cytokines. A study of the STAT5 regulated genes in human T cells using bioinformatics…”
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ID: 210 by Rani, Aradhana, Greenlaw, Roseanna, Galustian, Christine, Murphy, John

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Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers by Ribas, Ricardo, Ghazoui, Zara, Gao, Qiong, Pancholi, Sunil, Rani, Aradhana, Dunbier, Anita, Dowsett, Mitch, Martin, Lesley-Ann

“…Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to…”
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PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers by Coffey, Greg, Rani, Aradhana, Betz, Andreas, Pak, Yvonne, Haberstock‐Debic, Helena, Pandey, Anjali, Hollenbach, Stanley, Gretler, Daniel D., Mant, Tim, Jurcevic, Stipo, Sinha, Uma

“…The spleen tyrosine kinase (SYK) regulates immune cell activation in response to engagement of a variety of receptors, making it an intriguing target for the…”
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Abstract 4157: Co-blockade of mTORC1, ERBB and estrogen receptor signalling pathways in endocrine resistance breast cancer: Combating tumor plasticity by Ribas, Ricardo, Pancholi, Sunil, Guest, Stephanie K., Rani, Aradhana, Nikitorowicz-Buniak, Joanna, Simigdala, Nikiana, Thornhill, Allan, Cutler, Richard E., Lalani, Alshad S., Avogadri-Connors, Francesca, Dowsett, Mitch, Johnston, Stephen R., Martin, Lesley-Ann

“…Abstract Introduction The majority of breast cancers (BC) are estrogen (E) receptor positive (ER+). Endocrine therapies target E stimulation of tumour growth…”
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Abstract P3-05-04: AKT antagonist AZD5363 targets estrogen receptor (ER) function in endocrine resistant breast cancer (BC) and synergises with fulvestrant in vivo by Martin, Lesley-Ann, Guest, Stephanie K, Pancholi, Sunil, Ribas, Ricardo, Gao, Qiong, Simigdala, Nikiana, Rani, Aradhana, Davies, Barry, Johnston, Stephen, Dowsett, Mitch

“…Abstract AIM: To evaluate the efficacy and functional consquences of combining AZD5363 with endocrine therapy in pre-clinical models of endocrine-sensitive and…”
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125 STAT5 Regulated Genes Identified by Chromatin Immunoprecipitation by Rani, Aradhana, John, Susan

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