Search Results - "Ranges, GE"

Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression by Gerritsen, ME, Carley, WW, Ranges, GE, Shen, CP, Phan, SA, Ligon, GF, Perry, CA

“…Treatment of human endothelial cells with cytokines such as interleukin-1, tumor necrosis factor-alpha (TNF-alpha) or interferon-gamma induces the expression…”
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Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1 by Johns, LD, Flanders, KC, Ranges, GE, Sriram, S

“…Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine with immunosuppressive effects on T cells in vitro. Experimental allergic…”
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1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors by Dumas, Jacques, Hatoum-Mokdad, Holia, Sibley, Robert, Riedl, Bernd, Scott, William J, Monahan, Mary Katherine, Lowinger, Timothy B, Brennan, Catherine, Natero, Reina, Turner, Tiffany, Johnson, Jeffrey S, Schoenleber, Robert, Bhargava, Ajay, Wilhelm, Scott M, Housley, Timothy J, Ranges, Gerald E, Shrikhande, Alka

“…Inhibitors of the MAP kinase p38 are potentially useful for the treatment of arthritis and osteoporosis. Several 2,3-dichlorophenyl ureas were identified as…”
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Discovery of a new class of p38 kinase inhibitors by Dumas, Jacques, Sibley, Robert, Riedl, Bernd, Monahan, Mary Katherine, Lee, Wendy, Lowinger, Timothy B, Redman, Anikó M, Johnson, Jeffrey S, Kingery-Wood, Jill, Scott, William J, Smith, Roger A, Bobko, Mark, Schoenleber, Robert, Ranges, Gerald E, Housley, Timothy J, Bhargava, Ajay, Wilhelm, Scott M, Shrikhande, Alka

“…The MAP kinase p38 has been implicated in cytokine signaling, and its inhibitors are potentially useful for the treatment of arthritis and osteoporosis. Novel…”
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Inhibition of cytotoxic T cell development by transforming growth factor β and reversal by recombinant tumor necrosis factor α by RANGES, G. E, FIGARI, I. S, ESPEVIK, T, PALLADINO, M. A. JR

“…The immunoregulatory effects of transforming growth factor beta (TGF-beta) and recombinant murine tumor necrosis factor alpha (rMuTNF-alpha) on CTL generation…”
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p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas by Redman, Anikó M, Johnson, Jeffrey S, Dally, Robert, Swartz, Steve, Wild, Hanno, Paulsen, Holger, Caringal, Yolanda, Gunn, David, Renick, Joel, Osterhout, Martin, Kingery-Wood, Jill, Smith, Roger A, Lee, Wendy, Dumas, Jacques, Wilhelm, Scott M, Housley, Timothy J, Bhargava, Ajay, Ranges, Gerald E, Shrikhande, Alka, Young, Deborah, Bombara, Michael, Scott, William J

“…Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl,…”
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Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor by Dumas, Jacques, Hatoum-Mokdad, Holia, Sibley, Robert N, Smith, Roger A, Scott, William J, Khire, Uday, Lee, Wendy, Wood, Jill, Wolanin, Donald, Cooley, Jeffrey, Bankston, Donald, Redman, Aniko M, Schoenleber, Robert, Caringal, Yolanda, Gunn, David, Romero, Romulo, Osterhout, Martin, Paulsen, Holger, Housley, Timothy J, Wilhelm, Scott M, Pirro, John, Chien, Du-Shieng, Ranges, Gerald E, Shrikhande, Alka, Muzsi, Andrew, Bortolon, Elizabeth, Wakefield, Jean, Gianpaolo Ostravage, Cynthia, Bhargava, Ajay, Chau, Thuy

“…Inhibitors of the MAP kinase p38 provide a novel approach for the treatment of osteoporosis, inflammatory disorders, and cancer. We have identified N-(3-…”
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Inhibition of ceramide pathway does not affect ability of TNF-alpha to activate nuclear factor-kappa B by Johns, LD, Sarr, T, Ranges, GE

“…TNF-alpha is a multifunctional cytokine that has been shown to activate a number of intracellular second messenger pathways. Recent studies demonstrate that…”
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Tumor necrosis factor α/cachectin is a growth factor for thymocytes: synergistic interactions with other cytokines by RANGES, G. E, ZLOTNIK, A, ESPEVIK, T, DINARELLO, C. A, CERAMI, A, PALLADINO, M. A. JR

“…Recombinant murine (rm) TNF-alpha but not recombinant human (rh) TNF-alpha induces the proliferation of murine thymocytes in the presence of a comitogenic…”
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Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines by Bombara, M P, Webb, D L, Conrad, P, Marlor, C W, Sarr, T, Ranges, G E, Aune, T M, Greve, J M, Blue, M L

“…Human activated T cells adhere to synovial fibroblast-like cells in vitro. The present study was conducted to investigate the consequences of T cell-synovial…”
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Suppression of murine collagen-induced arthritis with monoclonal anti- Ia antibodies and augmentation with IFN-gamma by Cooper, SM, Sriram, S, Ranges, GE

“…Collagen-induced arthritis (CIA) is an experimental model in which a specific immune response to type II collagen (CII) is associated with the development of…”
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Tumor necrosis factor-alpha as a proliferative signal for an IL-2- dependent T cell line: strict species specificity of action by Ranges, GE, Bombara, MP, Aiyer, RA, Rice, GG, Palladino, MA, Jr

“…The ability of TNF-alpha to stimulate T cell proliferation was examined. We demonstrate that murine rTNF-alpha induces the proliferation of CT6, a murine T…”
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The involvement of human tumor necrosis factors-alpha and -beta in the mixed lymphocyte reaction by Shalaby, MR, Espevik, T, Rice, GC, Ammann, AJ, Figari, IS, Ranges, GE, Palladino, MA, Jr

“…The influence of recombinant human TNF-alpha and -beta (rHuTNF-alpha and -beta) in a human mixed lymphocyte reaction (MLR) was investigated. The addition of…”
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Serotonin-activated signal transduction via serotonin receptors on Jurkat cells by Aune, TM, Kelley, KA, Ranges, GE, Bombara, MP

“…Serotonin (5-hydroxytryptamine) (5HT) a neurotransmitter and vasoactive amine, is a major storage product of platelets that are released at sites of…”
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Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice by Janick-Buckner, D, Ranges, G E, Hacker, M P

“…Clinical use of the antitumor antibiotic bleomycin (BLM) is associated with the development of interstitial pulmonary fibrosis. Shortly after acute lung damage…”
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Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice by Janick-Buckner, D, Ranges, G E, Hacker, M P

“…Treatment of cancer patients with the antitumor antibiotic bleomycin (BLM) is associated with lung damage which can progress to pulmonary fibrosis. Shortly…”
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Anti-tumor necrosis factor receptor and tumor necrosis factor agonist activity by an anti-idiotypic antibody by Galloway, C J, Madanat, M S, Sarr, T, Espevik, T, Dumas, M L, Mitra, G, Ranges, G E

“…Tumor necrosis factor (TNF) is a cytokine which, among other properties, is a principle mediator of inflammation and septic shock. It acts upon target cells by…”
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Transforming growth factor- beta sub(1) (TGF- beta sub(1)) and recombinant human tumor necrosis factor- alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF- beta sub(1) and TGF- beta sub(2), and recombinant human TGF- beta sub(1) by Espevik, T, Figari, I S, Ranges, GE, Palladino, MA Jr

“…The authors have investigated the ability of porcine-plate-let-derived transforming growth factor- beta sub(1) (TGF- beta sub(1)) to inhibit the generation of…”
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In vivo immunomodulation by monoclonal anti-L3T4. 1. Effects on humoral and cell-mediated immune response by Ranges, G E, Cooper, S M, Sriram, S

“…The in vivo administration of monoclonal anti-L3T4 antibody has been shown to be an effective preventative and, in some cases, therapeutic treatment for…”
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Genomic cloning and heterologous expression of human differentiation-stimulating factor by Lowe, D G, Nunes, W, Bombara, M, McCabe, S, Ranges, G E, Henzel, W, Tomida, M, Yamamoto-Yamaguchi, Y, Hozumi, M, Goeddel, D V

“…Differentiation-stimulating factor (D-factor) purified from mouse Ehrlich ascites cells was sequenced partially and found to be almost identical to leukemia…”
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