Search Results - "Rangel Rivera, Guillermo O."

Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines by Dwyer, Connor J, Knochelmann, Hannah M, Smith, Aubrey S, Wyatt, Megan M, Rangel Rivera, Guillermo O, Arhontoulis, Dimitrios C, Bartee, Eric, Li, Zihai, Rubinstein, Mark P, Paulos, Chrystal M

“…Adoptive T cell transfer therapy (ACT) using tumor infiltrating lymphocytes or lymphocytes redirected with antigen receptors (CAR or TCR) has revolutionized…”
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Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma by Grohar, Patrick J., Kim, Suntae, Rangel Rivera, Guillermo O., Sen, Nirmalya, Haddock, Sara, Harlow, Matt L., Maloney, Nichole K., Zhu, Jack, O’Neill, Maura, Jones, Tamara L., Huppi, Konrad, Grandin, Magdalena, Gehlhaus, Kristen, Klumpp-Thomas, Carleen A., Buehler, Eugen, Helman, Lee J., Martin, Scott E., Caplen, Natasha J.

“…Ewing sarcoma cells depend on the EWS-FLI1 fusion transcription factor for cell survival. Using an assay of EWS-FLI1 activity and genome-wide RNAi screening,…”
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B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity by Smith, Aubrey S, Knochelmann, Hannah M, Wyatt, Megan M, Rangel Rivera, Guillermo O, Rivera-Reyes, Amalia M, Dwyer, Connor J, Ware, Michael B, Cole, Anna C, Neskey, David M, Rubinstein, Mark P, Liu, Bei, Thaxton, Jessica E, Bartee, Eric, Paulos, Chrystal M

“…BackgroundAdoptive T cell transfer (ACT) therapy improves outcomes in patients with advanced malignancies, yet many individuals relapse due to the infusion of…”
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Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy by Rangel Rivera, Guillermo O, Knochelmann, Hannah M, Dwyer, Connor J, Smith, Aubrey S, Wyatt, Megan M, Rivera-Reyes, Amalia M, Thaxton, Jessica E, Paulos, Chrystal M

“…Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to…”
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Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells by Dwyer, Connor J., Arhontoulis, Dimitrios C., Rangel Rivera, Guillermo O, Knochelmann, Hannah M., Smith, Aubrey S., Wyatt, Megan M., Rubinstein, Mark P., Atkinson, Carl, Thaxton, Jessica E., Neskey, David M., Paulos, Chrystal M.

“…Adoptive T cell transfer therapy induces objective responses in patients with advanced malignancies. Despite these results, some individuals do not respond due…”
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Progressively Enhancing Stemness of Adoptively Transferred T Cells with PI3Kδ Blockade Improves Metabolism and Antitumor Immunity by Rangel Rivera, Guillermo O., Dwyer, Connor J., Knochelmann, Hannah M., Smith, Aubrey S., Aksoy, Bülent Arman, Cole, Anna C., Wyatt, Megan M., Kumaresan, Soundharya, Thaxton, Jessica E., Lesinski, Gregory B., Paulos, Chrystal M.

“…Generating stem-like memory T cells (TSCM) is a potential strategy to improve adoptive immunotherapy. Elucidating optimal ways to modulate signaling pathways…”
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Sex Differences in Using Systemic Inflammatory Markers to Prognosticate Patients with Head and Neck Squamous Cell Carcinoma by Lin, Ching Ying, Kwon, Hyunwoo, Rangel Rivera, Guillermo O, Li, Xue, Chung, Dongjun, Li, Zihai

“…Remarkable discrepancy exists in outcomes between men and women for multiple malignancies. We sought to expose sex differences in using platelet count and…”
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IL6 Fuels Durable Memory for Th17 Cell-Mediated Responses to Tumors by Knochelmann, Hannah M, Dwyer, Connor J, Smith, Aubrey S, Bowers, Jacob S, Wyatt, Megan M, Nelson, Michelle H, Rangel Rivera, Guillermo O, Horton, Joshua D, Krieg, Carsten, Armeson, Kent, Lesinski, Gregory B, Rubinstein, Mark P, Li, Zihai, Paulos, Chrystal M

“…The accessibility of adoptive T-cell transfer therapies (ACT) is hindered by the cost and time required for product development. Here we describe a streamlined…”
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Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells by Wyatt, Megan M., Huff, Logan W., Nelson, Michelle H., Neal, Lillian R., Medvec, Andrew R., Rangel Rivera, Guillermo O., Smith, Aubrey S., Rivera Reyes, Amalia M., Knochelmann, Hannah M., Riley, James L., Lesinski, Gregory B., Paulos, Chrystal M.

“…IL-17-producing antigen-specific human T cells elicit potent antitumor activity in mice. Yet, refinement of this approach is needed to position it for clinical…”
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Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells by Wittling, Megen C, Knochelmann, Hannah M, Wyatt, Megan M, Rangel Rivera, Guillermo O, Cole, Anna C, Lesinski, Gregory B, Paulos, Chrystal M

“…BackgroundHow distinct methods of host preconditioning impact the efficacy of adoptively transferred antitumor T helper cells is unknown.MethodsCD4+ T cells…”
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Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies by Knochelmann, Hannah M, Rivera-Reyes, Amalia M, Wyatt, Megan M, Smith, Aubrey S, Chamness, Reilley, Dwyer, Connor J, Bobian, Michael, Rangel Rivera, Guillermo O, Horton, Joshuva D, Lilly, Michael, Romeo, Martin J, Timmers, Cynthia D, Rubinstein, Mark P, Neskey, David M, Paulos, Chrystal M

“…Adoptive transfer of tumor-infiltrating lymphocytes (TIL) elicits the regression of metastatic malignancies, yet a low proportion of patients achieve complete…”
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Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer by Riesenberg, Brian P, Hunt, Elizabeth G, Tennant, Megan D, Hurst, Katie E, Andrews, Alex M, Leddy, Lee R, Neskey, David M, Hill, Elizabeth G, Rivera, Guillermo O Rangel, Paulos, Chrystal M, Gao, Peng, Thaxton, Jessica E

“…Protein synthesis supports robust immune responses. Nutrient competition and global cell stressors in the tumor microenvironment (TME) may impact protein…”
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Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1 by Kim, Suntae, Olivero, Christiane, Rangel Rivera, Guillermo O., Sen, Nirmalya, Haddock, Sara, Huppi, Konrad, Helman, Lee J., Grohar, Patrick J., Caplen, Natasha J.

“…The primary oncogenic event in ∼85% of Ewing sarcomas is a t(11:22)(q24:q12) translocation. This translocation generates a fusion gene containing the 5’ end of…”
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1507 The Galectin-9-Tim-3 pathway is a novel checkpoint target for patients with biliary tract cancer by Warren, Emilie AK, Hammons, Jacklyn, Keilson, Jessica, Rangel-Rivera, Guillermo O, Wyatt, Megan M, Goel, Caroline R, Henry, Curtis J, Kulkarni, Sarah, Liu, Yuan, Robinson, Brian, Krasinskas, Alyssa, Maithel, Shishir, Paulos, Chrystal M, Lesinski, Gregory B

“…BackgroundWe have discovered that galectin-9 (Gal-9), a carbohydrate-binding protein, is expressed in biliary tract cancer (BTC). Upon binding to the receptor…”
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353 Adoptively transferred Th17 cells engage host B cells for durable tumor destruction by Cole, Anna C, Knochelmann, Hannah M, Rivera-Reyes, Amalia M, Smith, Aubrey S, Wyatt, Megan M, Pavuluri, Bhavana, Rangel Rivera, Guillermo O, Wittling, Megen, Ruffin, Ayana T, Kumaresan, Soundharya, Boss, Jeremy M, Lesinski, Gregory B, Paulos, Chrystal M

“…BackgroundAdoptive T cell transfer (ACT) therapy elicits robust immunity in some patients with aggressive malignancies. However, many individuals do not…”
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Inhibition of PI3Kδ improves tumor specific T cell immunity and metabolic fitness by Rangel Rivera, Guillermo O, Dwyer, Connor, Arthontoulis, Dimitrios, Knochelmann, Hannah, Smith, Aubrey S, Reyes, Amalia Rivera, Wyatt, Megan, Paulos, Chrystal M

“…Durable responses have been observed with adoptive T cell therapy (ACT) in some patients. However, current protocols used to expand T cells often exhibit…”
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CD26 enzymatic activity modulates efficient migration of adoptively transferred cancer-specific T cells to solid tumors by Wyatt, Megan M., Bailey, Stefanie, Knochelmann, Hannah, Smith, Aubrey S, Dwyer, Connor, Rivera, Guillermo O Rangel, Reyes, Amalia Rivera, Nelson, Michelle, Paulos, Chrystal M

“…The restricted ability of adoptively transferred T cells to eradicate solid tumors limits their use in some patients. Efforts to improve ACT for solid tumors…”
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T cells exhibit prolonged immunity against melanoma tumors expressing high, but not low affinity antigens by Rivera Reyes, Amalia M, Wyatt, Megan M., Dwyer, Connor J., Knochelmann, Hannah M., Smith, Aubrey S, Rangel Rivera, Guillermo O, Paulos, Chrystal M

“…We seek to identify the intrinsic properties in T cells from patients responsive or not to immunotherapy. Therapeutic efficacy is seen in patients where the…”
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IL-6 fuels durable memory for Th17 cell-mediated responses to tumors by Knochelmann, Hannah M, Dwyer, Connor J, Smith, Aubrey S, Bowers, Jacob S, Wyatt, Megan M, Nelson, Michelle H, Rivera, Guillermo O Rangel, Horton, Joshua D, Krieg, Carsten, Armeson, Kent, Lesinski, Gregory B, Rubinstein, Mark P, Li, Zihai, Paulos, Chrystal M

“…The accessibility of adoptive T cell transfer therapies (ACT) is hindered by cost and time required for product development. Here we describe a streamlined ACT…”
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Abstract IA04: Targeting the expression of EWS-FLI1 by Sen, Nirmalya, Ludwig, Katelyn, Rangel-Rivera, Guillermo O., Kim, Suntae, Huppi, Konrad, Jenkins, Lisa, Dwyer, Jennifer E., Hoover, Shelley, Helman, Lee, Simpson, Mark, Mendoza, Arnulfo, Hummon, Amanda B., Caplen, Natasha J.

“…Post-translational modifications (PTMs) of transcription factors represent potential therapeutic targets for a variety of diseases, including cancer. In the…”
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