Search Results - "Rangappa, Shobith"

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer by Totiger, Tulasigeri M, Srinivasan, Supriya, Jala, Venkatakrishna R, Lamichhane, Purushottam, Dosch, Austin R, Gaidarski, 3rd, Alexander A, Joshi, Chandrashekhar, Rangappa, Shobith, Castellanos, Jason, Vemula, Praveen Kumar, Chen, Xi, Kwon, Deukwoo, Kashikar, Nilesh, VanSaun, Michael, Merchant, Nipun B, Nagathihalli, Nagaraj S

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy and is highly resistant to standard treatment regimens. Targeted therapies against , a…”
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Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway by Mohan, Chakrabhavi Dhananjaya, Srinivasa, V, Rangappa, Shobith, Mervin, Lewis, Mohan, Surender, Paricharak, Shardul, Baday, Sefer, Li, Feng, Shanmugam, Muthu K, Chinnathambi, Arunachalam, Zayed, M E, Alharbi, Sulaiman Ali, Bender, Andreas, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S

“…Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential molecular therapeutic target in treatment of various cancers. Herein, we…”
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Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review by Uzma, Fazilath, Mohan, Chakrabhavi D, Hashem, Abeer, Konappa, Narasimha M, Rangappa, Shobith, Kamath, Praveen V, Singh, Bhim P, Mudili, Venkataramana, Gupta, Vijai K, Siddaiah, Chandra N, Chowdappa, Srinivas, Alqarawi, Abdulaziz A, Abd Allah, Elsayed F

“…Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global…”
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Synthesis, characterization and cytotoxicity studies of 1,2,3-triazoles and 1,2,4-triazolo [1,5-a] pyrimidines in human breast cancer cells by Gilandoust, Maryam, Harsha, Kachigere B., Mohan, Chakrabhavi Dhananjaya, Raquib, Ainiah Rushdiana, Rangappa, Shobith, Pandey, Vijay, Lobie, Peter E., Basappa, Rangappa, Kanchugarakoppal S.

“…[Display omitted] •VEGFR signalling is associated with the progression of various malignancies.•1,2,3-Triazoles and 1,2,4-triazolo-pyrimidines were synthesized…”
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Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers by Gebrehiwot, Abrha G, Melka, Daniel Seifu, Kassaye, Yimenashu Mamo, Rehan, Ibrahim F, Rangappa, Shobith, Hinou, Hiroshi, Kamiyama, Toshiya, Nishimura, Shin-Ichiro

“…Most glycomics studies have focused on understanding disease mechanisms and proposing serum markers for various diseases, yet the influence of ethnic variation…”
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Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells by Mohan, Chakrabhavi Dhananjaya, Anilkumar, Nirvanappa C, Rangappa, Shobith, Shanmugam, Muthu K, Mishra, Srishti, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Bhattacharjee, Atanu, Sethi, Gautam, Kumar, Alan Prem, Basappa, Rangappa, Kanchugarakoppal S

“…Aberrant activation of NF-κB is linked with the progression of human malignancies including hepatocellular carcinoma (HCC), and blockade of NF-κB signaling…”
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Six-substituted benzothiazole based dispersed azo dyes having antipyrine moiety: synthesis, characterization, DFT, antimicrobial, anticancer and molecular docking studies by Maliyappa, M. R., Keshavayya, J., Nazrulla, Mohammed Azeezulla, Sudhanva, M. S., Rangappa, Shobith

“…A series of benzothiazole based dispersed azo compounds were synthesized by diazotization of benzothiazole derivatives coupling with antipyrine through…”
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Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase by Vishwanath, Divakar, Girimanchanaika, Swamy S, Dukanya, Dukanya, Rangappa, Shobith, Yang, Ji-Rui, Pandey, Vijay, Lobie, Peter E, Basappa, Basappa

“…Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1…”
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Biofabrication of Zinc Oxide Nanoparticles With Syzygium aromaticum Flower Buds Extract and Finding Its Novel Application in Controlling the Growth and Mycotoxins of Fusarium graminearum by Lakshmeesha, Thimappa Ramachandrappa, Kalagatur, Naveen Kumar, Mudili, Venkataramana, Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Prasad, Bangari Daruka, Ashwini, Bagepalli Shivaram, Hashem, Abeer, Alqarawi, Abdulaziz A, Malik, Jahangir Ahmad, Abd Allah, Elsayed Fathi, Gupta, Vijai Kumar, Siddaiah, Chandra Nayaka, Niranjana, Siddapura Ramachandrappa

“…is a leading plant pathogen that causes Fusarium head blight, stalk rot, and Gibberella ear rot diseases in cereals and posing the immense threat to the…”
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Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma by Lee, Jong Hyun, Rangappa, Shobith, Mohan, Chakrabhavi Dhananjaya, Sethi, Gautam, Lin, Zhi-Xiu, Rangappa, Kanchugarakoppal S, Ahn, Kwang Seok

“…STAT3 is a latent transcription factor that plays a vital role in the transmission of extracellular signal from receptors to the nucleus. It has been regarded…”
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Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds by Mohan, Chakrabhavi Dhananjaya, Hari, Swetha, Preetham, Habbanakuppe D., Rangappa, Shobith, Barash, Uri, Ilan, Neta, Nayak, S. Chandra, Gupta, Vijai K., Basappa, Vlodavsky, Israel, Rangappa, Kanchugarakoppal S.

“…Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological…”
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Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells by Deveshegowda, Suresha N, Metri, Prashant K, Shivakumar, Rashmi, Yang, Ji-Rui, Rangappa, Shobith, Swamynayaka, Ananda, Shanmugam, Muthu K, Nagaraja, Omantheswara, Madegowda, Mahendra, Babu Shubha, Priya, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Ahn, Kwang Seok, Lobie, Peter E, Basappa, Basappa

“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
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In vitro, in vivo and in silico-driven identification of novel benzimidazole derivatives as anticancer and anti-inflammatory agents by Sathyanarayana, Reshma, Poojary, Boja, Srinivasa, Sudhanva M., Merugumolu, Vijay K., Chandrashekarappa, Revanasiddappa B., Rangappa, Shobith

“…The synthesis of novel benzimidazole derivatives with varied carbon chain length was achieved via “one-pot” nitro reductive cyclization ( 6a–o ). In each case,…”
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Synthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines by Keerthy, Hosadurga K, Garg, Manoj, Mohan, Chakrabhavi D, Madan, Vikas, Kanojia, Deepika, Shobith, Rangappa, Nanjundaswamy, Shivananju, Mason, Daniel J, Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S, Koeffler, H Phillip

“…The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated…”
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Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity by Baburajeev, C P, Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J, Fuchs, Julian E, Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S

“…Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and…”
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Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent by Preetham, Habbanakuppe D., Umashankara, M., Kumar, Kothanahally S. Sharath, Rangappa, Shobith, Rangappa, Kanchugarakoppal S.

“…Pyrrolidine-based cationic peptides showing high stability to enzyme degradation and strong binding affinity towards DNA are widely investigated as tools to…”
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3-Formylchromone Counteracts STAT3 Signaling Pathway by Elevating SHP-2 Expression in Hepatocellular Carcinoma by Mohan, Chakrabhavi Dhananjaya, Yang, Min Hee, Rangappa, Shobith, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Alahmadi, Tahani Awad, Deivasigamani, Amudha, Hui, Kam Man, Sethi, Gautam, Rangappa, Kanchugarakoppal S, Ahn, Kwang Seok

“…Hepatocellular carcinoma (HCC) is one of the leading cancers that contribute to a large number of deaths throughout the globe. The signal transducer and…”
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Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo by Nirvanappa, Anilkumar C, Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Ananda, Hanumappa, Sukhorukov, Alexey Yu, Shanmugam, Muthu K, Sundaram, Mahalingam S, Nayaka, Siddaiah Chandra, Girish, Kesturu S, Chinnathambi, Arunachalam, Zayed, M E, Alharbi, Sulaiman Ali, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S

“…Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis of several proinflammatory diseases including number of cancers and…”
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N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway by Mohan, Chakrabhavi Dhananjaya, Bharathkumar, Hanumantharayappa, Dukanya, Rangappa, Shobith, Shanmugam, Muthu K, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Alahmadi, Tahani Awad, Bhattacharjee, Atanu, Lobie, Peter E, Deivasigamani, Amudha, Hui, Kam Man, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S, Kumar, Alan Prem

“…Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the…”
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Furan-2-carboxamide derivative, a novel microtubule stabilizing agent induces mitotic arrest and potentiates apoptosis in cancer cells by Shwetha, B, Sudhanva, M. Srinivasa, Jagadeesha, G.S, Thimmegowda, N.R, Hamse, Vivek K., Sridhar, B.T, Thimmaiah, K.N, Ananda Kumar, C.S, Shobith, Rangappa, Rangappa, K.S

“…[Display omitted] •SH09, induces mitotic arrest and promotes apoptosis in various cancer cells.•SH09, decreases colony formation and mitigates invasion and…”
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