Search Results - "Rangan, Gopala K."

Effects of Allopurinol on the Progression of Chronic Kidney Disease by Badve, Sunil V, Pascoe, Elaine M, Tiku, Anushree, Boudville, Neil, Brown, Fiona G, Cass, Alan, Clarke, Philip, Dalbeth, Nicola, Day, Richard O, de Zoysa, Janak R, Douglas, Bettina, Faull, Randall, Harris, David C, Hawley, Carmel M, Jones, Graham R.D, Kanellis, John, Palmer, Suetonia C, Perkovic, Vlado, Rangan, Gopala K, Reidlinger, Donna, Robison, Laura, Walker, Robert J, Walters, Giles, Johnson, David W

“…This randomized trial assessed whether urate-lowering treatment with allopurinol could attenuate eGFR decline in at-risk patients with stage 3 or 4 chronic…”
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Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease by Saravanabavan, Sayanthooran, Rangan, Gopala K

“…Increased DNA damage response (DDR) signaling in kidney cyst-lining epithelial cells (CECs) may provide an opportunity for cell-specific therapeutic targeting…”
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Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis by Bose, Bhadran, Badve, Sunil V, Hiremath, Swapnil S, Boudville, Neil, Brown, Fiona G, Cass, Alan, de Zoysa, Janak R, Fassett, Robert G, Faull, Randall, Harris, David C, Hawley, Carmel M, Kanellis, John, Palmer, Suetonia C, Perkovic, Vlado, Pascoe, Elaine M, Rangan, Gopala K, Walker, Robert J, Walters, Giles, Johnson, David W

“…Non-randomized studies suggest an association between serum uric acid levels and progression of chronic kidney disease (CKD). The aim of this systematic review…”
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Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease by Chandra, Ashley N., Saravanabavan, Sayanthooran, Rangan, Gopala K.

“…DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein involved in DNA damage response (DDR) signaling that may mediate kidney cyst growth in…”
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Increased water intake reduces long-term renal and cardiovascular disease progression in experimental polycystic kidney disease by Sagar, Priyanka S, Zhang, Jennifer, Luciuk, Magda, Mannix, Carly, Wong, Annette T Y, Rangan, Gopala K

“…Polycystic kidney disease (PKD) is the most common inherited cause of kidney failure and currently has limited treatment options. Increasing water intake…”
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Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells by Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K, Hu, Min, Henderson, Beric R, Alexander, Stephen I, Harris, David C.H

“…Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of…”
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Quantification of renal pathology by image analysis (Methods in Renal Research) by RANGAN, GOPALA K, TESCH, GREG H

“…Recent advances in computer image analysis techniques allow more accurate quantification of kidney pathological lesions, which are identified by histological…”
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Long-term dietary nitrate supplementation does not reduce renal cyst growth in experimental autosomal dominant polycystic kidney disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Cheng, Kai Man, Raghubanshi, Aarya, Chandra, Ashley N, Munt, Alexandra, Rayner, Benjamin, Zhang, Yunjia, Chau, Katrina, Wong, Annette T Y, Rangan, Gopala K

“…Augmentation of endogenous nitric oxide (NO) synthesis, either by the classical L-arginine-NO synthase pathway, or the recently discovered entero-salivary…”
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Efficacy of beetroot juice on reducing blood pressure in hypertensive adults with autosomal dominant polycystic kidney disease (BEET-PKD): study protocol for a double-blind, randomised, placebo-controlled trial by Sagar, Priyanka S, Munt, Alexandra, Saravanabavan, Sayanthooran, Vahedi, Farnoosh Asghar, Elhindi, James, Nguyen, Beatrice, Chau, Katrina, Harris, David C, Lee, Vincent, Sud, Kamal, Wong, Nikki, Rangan, Gopala K

“…In autosomal dominant polycystic kidney disease (ADPKD) impaired nitric oxide (NO) synthesis, in part, contributes to early-onset hypertension. Beetroot juice…”
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Patient-reported outcome measures for pain in autosomal dominant polycystic kidney disease: A systematic review by Natale, Patrizia, Hannan, Elyssa, Sautenet, Bénédicte, Ju, Angela, Perrone, Ronald D, Burnette, Eva, Casteleijn, Niek, Chapman, Arlene, Eastty, Sarah, Gansevoort, Ron, Hogan, Marie, Horie, Shigeo, Knebelmann, Bertrand, Lee, Richard, Mustafa, Reem A, Sandford, Richard, Baumgart, Amanda, Tong, Allison, Strippoli, Giovanni F. M, Craig, Jonathan C, Rangan, Gopala K, Cho, Yeoungjee

“…Pain is a common symptom in people with autosomal dominant polycystic kidney disease (ADPKD), but it is assessed and reported inconsistently in research, and…”
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Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease by Zhang, Jennifer Q J, Saravanabavan, Sayanthooran, Rangan, Gopala K

“…The DNA damage response (DDR) pathway is upregulated in autosomal dominant polycystic kidney disease (ADPKD) but its functional role is not known. The…”
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Role of interstitial inflammation in the pathogenesis of polycystic kidney disease by Ta, Michelle HT, Harris, David CH, Rangan, Gopala K

“…Interstitial infiltrates, consisting of macrophages and other inflammatory cells, have been consistently reported in human and animal models of polycystic…”
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KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Diet and Lifestyle Management by Campbell, Katrina L., APD, PhD, Rangan, Gopala K., MB BS, PhD, FRACP, Lopez-Vargas, Pamela, MPH, Tong, Allison, PhD

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KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Management of Polycystic Liver Disease by Savige, Judy, MB BS, PhD, FRACP, Mallett, Andrew, MB BS, MMed, AFRACMA, FRACP, Tunnicliffe, David J., MIPH, Rangan, Gopala K., MB BS, PhD, FRACP

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Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease by Ta, Michelle H T, Schwensen, Kristina G, Foster, Sheryl, Korgaonkar, Mayuresh, Ozimek-Kulik, Justyna E, Phillips, Jacqueline K, Peduto, Anthony, Rangan, Gopala K

“…The disease-modifying effects of target of rapamycin complex 1 (TORC1) inhibitors during different stages of polycystic kidney disease (PKD) are not well…”
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KHA-CARI Autosomal Dominant Polycystic Kidney Disease Guideline: Management of Renal Stone Disease by Mallett, Andrew, MB BS, MMed, AFRACMA, FRACP, Patel, Manish, MB BS, MMed, PhD, FRACS, Tunnicliffe, David J., MIPH, Rangan, Gopala K., MB BS, PhD, FRACP

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RAPID-ADPKD (Retrospective epidemiological study of Asia-Pacific patients with rapId Disease progression of Autosomal Dominant Polycystic Kidney Disease): study protocol for a multinational, retrospective cohort study by Ryu, Hyunjin, Park, Hayne C, Oh, Yun Kyu, Sangadi, Irene, Wong, Annette, Mei, Changlin, Ecder, Tevfik, Wang, Angela Yee-Moon, Kao, Tze-Wah, Huang, Jenq-Wen, Rangan, Gopala K, Ahn, Curie

“…IntroductionPatients with autosomal dominant polycystic kidney disease (ADPKD) reach end-stage renal disease in their fifth decade on average. For effective…”
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Effect of Early and Delayed Commencement of Paricalcitol in Combination with Enalapril on the Progression of Experimental Polycystic Kidney Disease by Sagar, Priyanka S., Saravanabavan, Sayanthooran, Munt, Alexandra, Wong, Annette T. Y., Rangan, Gopala K.

“…Vitamin D secosteroids are intranuclear regulators of cellular growth and suppress the renin-angiotensin system. The aim of this study was to test the…”
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Autosomal Dominant Polycystic Kidney Disease: A Path Forward by Rangan, Gopala K., MBBS, PhD, Lopez-Vargas, Pamela, MPH, Nankivell, Brian J., MBBS, MD, PhD, FRACP, MRCP, Tchan, Michel, MBBS, FRACP, PhD, Tong, Allison, PhD, Tunnicliffe, David J., MIPH, Savige, Judy, MBBS, PhD, FRACP

“…Summary Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited cause of renal failure in adults, and is due to loss-of-function…”
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Sirolimus-associated proteinuria and renal dysfunction by RANGAN, Gopala K

“…Sirolimus is a novel immunosuppressant with potent antiproliferative actions through its ability to inhibit the raptor-containing mammalian target of rapamycin…”
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