Search Results - "Rane, Neena S."

Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway by Kang, Sang-Wook, Rane, Neena S., Kim, Soo Jung, Garrison, Jennifer L., Taunton, Jack, Hegde, Ramanujan S.

“…Eukaryotic proteins entering the secretory pathway are translocated into the ER by signal sequences that vary widely in primary structure. We now provide a…”
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Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein by Rane, Neena S, Chakrabarti, Oishee, Feigenbaum, Lionel, Hegde, Ramanujan S

“…Protein translocation into the endoplasmic reticulum is mediated by signal sequences that vary widely in primary structure. In vitro studies suggest that such…”
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Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to Neurodegeneration by Rane, Neena S., Kang, Sang-Wook, Chakrabarti, Oishee, Feigenbaum, Lionel, Hegde, Ramanujan S.

“…During acute stress in the endoplasmic reticulum (ER), mammalian prion protein (PrP) is temporarily prevented from translocation into the ER and instead routed…”
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Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins by Chakrabarti, Oishee, Rane, Neena S, Hegde, Ramanujan S

“…A wide range of diseases are associated with the accumulation of cytosolic protein aggregates. The effects of these aggregates on various aspects of normal…”
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Protection from cytosolic prion protein toxicity by modulation of protein translocation by Rane, Neena S, Yonkovich, Jesse L, Hegde, Ramanujan S

“…Failure to promptly dispose of undesirable proteins is associated with numerous diseases. In the case of cellular prion protein (PrP), inhibition of the…”
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Prion protein trafficking and the development of neurodegeneration by Hegde, Ramanujan S., Rane, Neena S.

“…The prion protein (PrP) is involved in causing a group of diverse transmissible, heritable and sporadically occurring neurodegenerative diseases. Although the…”
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Restoration of senescence in breast and ovarian cancer cells following the transfer of the YAC carrying SEN6A gene located at 6q16.3 by Rane, Neena S, Sandhu, Arbansjit K, Zhawar, Vikramjit S, Kaur, Gurpreet, Popescu, Nicholas C, Kandpal, Raj P, Jhanwar-Uniyal, Meena, Athwal, Raghbir S

“…We previously located a senescence gene locus (SEN6A), at chromosome 6q14-21 by a functional strategy using chromosome transfer into immortal ovarian tumor…”
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High-resolution mapping and functional characterization of SEN6A locus that restores senescence in ovarian tumor cells by Rane, Neena S

“…Normal diploid cells exhibit a limited replicative life-span in vitro and in vivo ending in a post-mitotic growth arrest called ‘replicative senescence’. In…”
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