Search Results - "Rane, Madhavi J."

Krϋppel-like factors (KLFs) in renal physiology and disease by Rane, Madhavi J., Zhao, Yuguang, Cai, Lu

“…Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of…”
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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans by Chen, Shu G., Stribinskis, Vilius, Rane, Madhavi J., Demuth, Donald R., Gozal, Evelyne, Roberts, Andrew M., Jagadapillai, Rekha, Liu, Ruolan, Choe, Kyonghwan, Shivakumar, Bhooma, Son, Francheska, Jin, Shunying, Kerber, Richard, Adame, Anthony, Masliah, Eliezer, Friedland, Robert P.

“…Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for…”
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Understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective versus deleterious inflammatory response in pneumonia by Bordon, Jose, Aliberti, Stefano, Fernandez-Botran, Rafael, Uriarte, Silvia M, Rane, Madhavi J, Duvvuri, Padmaraj, Peyrani, Paula, Morlacchi, Letizia Corinna, Blasi, Francesco, Ramirez, Julio A

“…Summary Inflammation is a double-edged sword in the outcome of pneumonia. On the one hand, an effective and timely inflammatory response is required to…”
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Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst by Uriarte, Silvia M, Rane, Madhavi J, Luerman, Gregory C, Barati, Michelle T, Ward, Richard A, Nauseef, William M, McLeish, Kenneth R

“…The role of exocytosis in the human neutrophil respiratory burst was determined using a fusion protein (TAT-SNAP-23) containing the HIV transactivator of…”
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Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation by Jagadapillai, Rekha, Rane, Madhavi J, Lin, Xingyu, Roberts, Andrew M, Hoyle, Gary W, Cai, Lu, Gozal, Evelyne

“…Diabetes is strongly associated with systemic inflammation and oxidative stress, but its effect on pulmonary vascular disease and lung function has often been…”
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Prevention of Diabetic Nephropathy by Sulforaphane : Possible Role of Nrf2 Upregulation and Activation by Cui, Wenpeng, Bai, Yang, Miao, Xiao, Luo, Ping, Chen, Qiang, Tan, Yi, Rane, Madhavi J., Miao, Li-ning, Cai, Lu

“…The present study was to investigate whether sulforaphane (SFN) can prevent diabetic nephropathy in type 1 diabetic mouse model induced by multiple low-dose…”
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Hsp27 Regulates Akt Activation and Polymorphonuclear Leukocyte Apoptosis by Scaffolding MK2 to Akt Signal Complex by Wu, Rui, Kausar, Hina, Johnson, Paul, Montoya-Durango, Diego E., Merchant, Michael, Rane, Madhavi J.

“…We have shown previously that Akt exists in a signal complex with p38 MAPK, MAPK-activated protein kinase-2 (MK2), and heat shock protein 27 (Hsp27) and MK2…”
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Differential Functional Responses of Neutrophil Subsets in Severe COVID-19 Patients by McLeish, Kenneth R., Shrestha, Rejeena, Vashishta, Aruna, Rane, Madhavi J., Barati, Michelle T., Brier, Michael E., Lau, Mario Gutierrez, Hu, Xiaoling, Chen, Oscar, Wessel, Caitlin R., Spalding, Travis, Bush, Sarah E., Ijemere, Kenechi, Hopkins, C. Danielle, Cooke, Elizabeth A., Tandon, Shweta, Manning, Terri, Uriarte, Silvia M., Huang, Jiapeng, Yan, Jun

“…Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil…”
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PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells by Gozal, Evelyne, Metz, Cynthia J., Dematteis, Maurice, Sachleben, Leroy R., Schurr, Avital, Rane, Madhavi J.

“…Hypoxia is a primary factor in many pathological conditions. Hypoxic cell death is commonly attributed to metabolic failure and oxidative injury…”
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Human neutrophils depend on extrinsic factors produced by monocytes for their survival response to TLR4 stimulation by SenGupta, Shuvasree, Rane, Madhavi J, Uriarte, Silvia M, Woolley, Cassandra, Mitchell, Thomas C

“…LPS delays neutrophil apoptosis by a process generally assumed to involve cell-intrinsic TLR4 signaling. However, neutrophil survival responses to LPS have…”
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Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation by Rane, Madhavi J., Pan, Yong, Singh, Saurabh, Powell, David W., Wu, Rui, Cummins, Timothy, Chen, Qingdan, McLeish, Kenneth R., Klein, Jon B.

“…Activation of the serine-threonine kinase Akt by cytokines, chemokines, and bacterial products delays constitutive neutrophil apoptosis, resulting in a…”
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Regulation of neutrophil apoptosis by modulation of PKB/Akt activation by Rane, Madhavi J, Klein, Jon B

“…The serine/threonine kinase, Akt, also known as PKB (Protein Kinase B) is one important signal transduction pathway that mediates the delay of neutrophil…”
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Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats by Uriarte, Silvia M, Rane, Madhavi J, Merchant, Michael L, Jin, Shunying, Lentsch, Alex B, Ward, Richard A, McLeish, Kenneth R

“…Exocytosis of neutrophil granules contributes to acute lung injury (ALI) induced by infection or inflammation, suggesting that inhibition of neutrophil…”
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The actin cytoskeleton regulates exocytosis of all neutrophil granule subsets by Jog, Neelakshi R, Rane, Madhavi J, Lominadze, George, Luerman, Gregory C, Ward, Richard A, McLeish, Kenneth R

“…A comprehensive analysis of the role of the actin cytoskeleton in exocytosis of the four different neutrophil granule subsets had not been performed…”
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Attenuation of Diabetes-Induced Cardiac Inflammation and Pathological Remodeling by Low-Dose Radiation by Zhang, Chi, Jin, Shunzi, Guo, Weiying, Li, Cai, Li, Xiaokun, Rane, Madhavi J., Wang, Guanjun, Cai, Lu

“…In the present study, novel preventive effects of repeated low-dose radiation exposure on diabetes-induced cardiac inflammation and cardiac damage were…”
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Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators by Jin, Shunying, Merchant, Michael L, Ritzenthaler, Jeffrey D, McLeish, Kenneth R, Lederer, Eleanor D, Torres-Gonzalez, Edilson, Fraig, Mostafa, Barati, Michelle T, Lentsch, Alex B, Roman, Jesse, Klein, Jon B, Rane, Madhavi J

“…Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute…”
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Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex by Clark, Christina B., Rane, Madhavi J., El Mehdi, Delphine, Miller, Cynthia J., Sachleben, Leroy R., Gozal, Evelyne

“…Heat shock protein 90 (Hsp90) is a chaperone protein regulating PC-12 cell survival by binding and stabilizing Akt, Raf-1, and Cdc37. Hsp90 inhibitor…”
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Ouabain induces cell proliferation through calcium-dependent phosphorylation of Akt (protein kinase B) in opossum kidney proximal tubule cells by Khundmiri, Syed J, Metzler, Melissa A, Ameen, Mohamed, Amin, Vishal, Rane, Madhavi J, Delamere, Nicholas A

“…Cardiotonic glycosides, like ouabain, inhibit Na(+)-K(+)-ATPase. Recent evidence suggests that low molar concentrations of ouabain alter cell growth. Studies…”
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Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications by Zhao, Yuguang, Song, Wenjing, Wang, Lizhe, Rane, Madhavi J., Han, Fujun, Cai, Lu

“…Although there is an increasing understanding of the signaling pathways that promote cardiac hypertrophy, negative regulatory factors of this process have…”
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Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways by Klein, Jon B, Rane, Madhavi J, Scherzer, Janice A, Coxon, Patricia Y, Kettritz, Ralph, Mathiesen, Jeanine M, Buridi, Abdul, McLeish, Kenneth R

“…Activated neutrophils play an important role in the pathogenesis of sepsis, glomerulonephritis, acute renal failure, and other inflammatory processes. The…”
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