Search Results - "Randy A. Hall"

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology by Lala, Trisha, Hall, Randy A

“…Adhesion G protein-coupled receptors (AGPCRs) are a family of 33 receptors in humans exhibiting a conserved general structure but diverse expression patterns…”
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Adhesion G Protein-Coupled Receptors as Drug Targets by Purcell, Ryan H, Hall, Randy A

“…The adhesion G protein-coupled receptors (aGPCRs) are an evolutionarily ancient family of receptors that play key roles in many different physiological…”
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Fine-tuning of GPCR activity by receptor-interacting proteins by Hall, Randy A, Ritter, Stefanie L

“…Key Points G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane proteins that can be activated by a diverse array of ligands,…”
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Adhesion G protein-coupled receptors: signaling, pharmacology, and mechanisms of activation by Paavola, Kevin J, Hall, Randy A

“…The adhesion G protein-coupled receptors (GPCRs) are a distinct family of more than 30 receptors in vertebrate genomes. These receptors have been shown to play…”
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GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin by Meyer, Rebecca C., Giddens, Michelle M., Schaefer, Stacy A., Hall, Randy A.

“…GPR37 (also known as Pael-R) and GPR37L1 are orphan G protein-coupled receptors that are almost exclusively expressed in the nervous system. We screened these…”
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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors by Hamann, Jörg, Aust, Gabriela, Araç, Demet, Engel, Felix B, Formstone, Caroline, Fredriksson, Robert, Hall, Randy A, Harty, Breanne L, Kirchhoff, Christiane, Knapp, Barbara, Krishnan, Arunkumar, Liebscher, Ines, Lin, Hsi-Hsien, Martinelli, David C, Monk, Kelly R, Peeters, Miriam C, Piao, Xianhua, Prömel, Simone, Schöneberg, Torsten, Schwartz, Thue W, Singer, Kathleen, Stacey, Martin, Ushkaryov, Yuri A, Vallon, Mario, Wolfrum, Uwe, Wright, Mathew W, Xu, Lei, Langenhan, Tobias, Schiöth, Helgi B

“…The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly…”
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The protective role of prosaposin and its receptors in the nervous system by Meyer, Rebecca C, Giddens, Michelle M, Coleman, Brilee M, Hall, Randy A

“…Abstract Prosaposin (also known as SGP-1) is an intriguing multifunctional protein that plays roles both intracellularly, as a regulator of lysosomal enzyme…”
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Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling by Kishore, Ayush, Hall, Randy A.

“…Mutations to the adhesion G protein-coupled receptor ADGRG1 (G1; also known as GPR56) underlie the neurological disorder bilateral frontoparietal…”
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Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development by Shiu, Fu Hung, Wong, Jennifer C., Yamamoto, Takahiro, Lala, Trisha, Purcell, Ryan H., Owino, Sharon, Zhu, Dan, Van Meir, Erwin G., Hall, Randy A., Escayg, Andrew

“…The adhesion G protein-coupled receptor BAI1/ADGRB1 plays an important role in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor…”
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The BAI subfamily of adhesion GPCRs: synaptic regulation and beyond by Stephenson, Jason R, Purcell, Ryan H, Hall, Randy A

“…Highlights • BAI1, BAI2, and BAI3 are receptors that can regulate neuronal function and synaptogenesis. • BAI1 has been shown to signal via both G protein and…”
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The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity by Paavola, Kevin J., Stephenson, Jason R., Ritter, Stefanie L., Alter, Shawn P., Hall, Randy A.

“…GPR56 is an adhesion G protein-coupled receptor that plays a key role in cortical development. Mutations to GPR56 in humans cause malformations of the cerebral…”
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Brain-specific Angiogenesis Inhibitor-1 Signaling, Regulation, and Enrichment in the Postsynaptic Density by Stephenson, Jason R., Paavola, Kevin J., Schaefer, Stacy A., Kaur, Balveen, Van Meir, Erwin G., Hall, Randy A.

“…Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor that has been studied primarily for its anti-angiogenic and…”
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A disease‐associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity by Purcell, Ryan H., Toro, Camilo, Gahl, William A., Hall, Randy A.

“…Mutations in G protein‐coupled receptors (GPCRs) that increase constitutive signaling activity can cause human disease. A de novo C‐terminal mutation (R1465W)…”
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Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance by Prinster, Steven C, Hague, Chris, Hall, Randy A

“…G protein-coupled receptors (GPCRs) are cell surface receptors that mediate physiological responses to a diverse array of stimuli. GPCRs have traditionally…”
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Genome-wide Functional Annotation of Dual-Specificity Protein- and Lipid-Binding Modules that Regulate Protein Interactions by Chen, Yong, Sheng, Ren, Källberg, Morten, Silkov, Antonina, Tun, Moe P., Bhardwaj, Nitin, Kurilova, Svetlana, Hall, Randy A., Honig, Barry, Lu, Hui, Cho, Wonhwa

“…Emerging evidence indicates that membrane lipids regulate protein networking by directly interacting with protein-interaction domains (PIDs). As a pilot study…”
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Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination by Smith, Brilee M, Giddens, Michelle M, Neil, Jessica, Owino, Sharon, Nguyen, TrangKimberly T, Duong, Duc, Li, Fengqiao, Hall, Randy A

“…Highlights • Myelin-associated glycoprotein expression is lower in brains of mice lacking GPR37. • Loss of GPR37 results in increased susceptibility to…”
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The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation by Wang, Yubin, Hall, Randy A., Lee, Moses, Kamgar-parsi, Andysheh, Bi, Xiaoning, Baudry, Michel

“…Traumatic brain injury (TBI) increases the risk of Alzheimer’s disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI…”
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GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant by Giddens, Michelle M., Wong, Jennifer C., Schroeder, Jason P., Farrow, Emily G., Smith, Brilee M., Owino, Sharon, Soden, Sarah E., Meyer, Rebecca C., Saunders, Carol, LePichon, J.B., Weinshenker, David, Escayg, Andrew, Hall, Randy A.

“…Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive neurological deterioration. While…”
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Autonomic modulation of olfactory signaling by Hall, Randy A

“…The olfactory epithelium is extensively innervated by sympathetic nerve endings, which release norepinephrine, and parasympathetic nerve endings, which release…”
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A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism by Courbebaisse, Marie, Leroy, Christine, Bakouh, Naziha, Salaün, Christine, Beck, Laurent, Grandchamp, Bernard, Planelles, Gabrielle, Hall, Randy A, Friedlander, Gérard, Prié, Dominique

“…The sodium-hydrogen exchanger regulatory factor 1 (NHERF1) binds to the main renal phosphate transporter NPT2a and to the parathyroid hormone (PTH) receptor…”
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