Search Results - "Randrian, Violaine"

Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer by Evrard, Camille, Tachon, Gaëlle, Randrian, Violaine, Karayan-Tapon, Lucie, Tougeron, David

“…Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of Lynch syndrome and decision making regarding adjuvant chemotherapy in…”
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Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging Therapies by Randrian, Violaine, Evrard, Camille, Tougeron, David

“…A defect in the DNA repair system through a deficient mismatch repair system (dMMR) leads to microsatellite instability (MSI). Microsatellites are located in…”
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Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation by Yuseff, Maria-Isabel, Reversat, Anne, Lankar, Danielle, Diaz, Jheimmy, Fanget, Isabelle, Pierobon, Paolo, Randrian, Violaine, Larochette, Nathanael, Vascotto, Fulvia, Desdouets, Chantal, Jauffred, Bertrand, Bellaiche, Yohanns, Gasman, Stéphane, Darchen, François, Desnos, Claire, Lennon-Duménil, Ana-Maria

“…Engagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation of a synapse that promotes Ag uptake for presentation onto major…”
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New Artificial Intelligence Score and Immune Infiltrates as Prognostic Factors in Colorectal Cancer With Brain Metastases by Randrian, Violaine, Desette, Amandine, Emambux, Sheik, Derangere, Valentin, Roussille, Pauline, Frouin, Eric, Godet, Julie, Karayan-Tapon, Lucie, Ghiringhelli, François, Tougeron, David

“…Incidence of brain metastases has increased in patients with colorectal cancer (CRC) as their survival has improved. CD3 T-cells and, lately, DGMate (DiGital…”
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Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers by Evrard, Camille, Messina, Stéphane, Sefrioui, David, Frouin, Éric, Auriault, Marie-Luce, Chautard, Romain, Zaanan, Aziz, Jaffrelot, Marion, De La Fouchardière, Christelle, Aparicio, Thomas, Coriat, Romain, Godet, Julie, Silvain, Christine, Randrian, Violaine, Sabourin, Jean-Christophe, Guimbaud, Rosine, Miquelestorena-Standley, Elodie, Lecomte, Thierry, Moulin, Valérie, Karayan-Tapon, Lucie, Tachon, Gaëlle, Tougeron, David

“…Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about 5% of metastatic colorectal cancers (mCRCs) with a major therapeutic…”
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HSP110 as a Diagnostic but Not a Prognostic Biomarker in Colorectal Cancer With Microsatellite Instability by Tachon, Gaelle, Chong-Si-Tsaon, Arnaud, Lecomte, Thierry, Junca, Audelaure, Frouin, Éric, Miquelestorena-Standley, Elodie, Godet, Julie, Evrard, Camille, Randrian, Violaine, Chautard, Romain, Auriault, Marie-Luce, Moulin, Valérie, Guyetant, Serge, Fromont, Gaelle, Karayan-Tapon, Lucie, Tougeron, David

“…Determination of microsatellite instability (MSI) using molecular test and deficient mismatch repair (dMMR) using immunohistochemistry (IHC) has major…”
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Hepatic Arterial Infusion Chemotherapy With Folfirinox or Oxaliplatin Alone in Metastatic Colorectal Cancer by Randrian, Violaine, Pernot, Simon, Sionneau, Baptiste, Smith, Denis, Lim, Annie, Touchefeu, Yann, Gallois, Claire, Turpin, Anthony, Javed, Sahir, Guimbaud, Rosine, Rivera, Pascale, Karoui, Mehdi, Auclin, Edouard, Taieb, Julien

“…Background Hepatic arterial infusion (HAI) of chemotherapy is an option for the treatment of patients with liver metastases from colorectal cancer (LMCRC)…”
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337 Pembrolizumab in combination with xelox bevacizumab in patients with microsatellite stable (MSS) metastatic colorectal cancer and a high immune infiltrate: a proof of concept study. FFCD 1703 POCHI by Tougeron, David, Emile, Jean Francois, Kim, Stephano, Monterymard, Carole, Gilabert, Marine, Jérémie, BEZ, Lievre, Astrid, Dahan, Laetitia, Laurent-puig, Pierre, Mineur, Laurent, Coriat, ROmain, Legoux, Jean Louis, Hautefeuille, Vincent, Phelip, Jean marc, Lecomte, Thierry, Sokol, Harry, Capron, Claude, Gallois, Claire, Randrian, Violaine, Lepage, Come, Taieb, Julien

“…BackgroundImmune checkpoint inhibitors (ICI) are very effective in deficient DNA mismatch-repair system (dMMR)/microsatellite instable (MSI) metastatic…”
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Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study by Dasari, Arvind, Lonardi, Sara, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto, Yao, James, García-Alfonso, Pilar, Kocsis, Judit, Cubillo Gracian, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Paulson, Andrew Scott, Masuishi, Toshiki, Jones, Jeremy, Csőszi, Tibor, Cremolini, Chiara, Ghiringhelli, Francois, Shergill, Ardaman, Hochster, Howard S, Krauss, John, Bassam, Ali, Ducreux, Michel, Elme, Anneli, Faugeras, Laurence, Kasper, Stefan, Van Cutsem, Eric, Arnold, Dirk, Nanda, Shivani, Yang, Zhao, Schelman, William R, Kania, Marek, Tabernero, Josep, Eng, Cathy

“…There is a paucity of effective systemic therapy options for patients with advanced, chemotherapy-refractory colorectal cancer. We aimed to evaluate the…”
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Circulating tumor DNA in unresectable pancreatic cancer is a strong predictor of first-line treatment efficacy: The KRASCIPANC prospective study by Evrard, Camille, Ingrand, Pierre, Rochelle, Tristan, Martel, Marine, Tachon, Gaëlle, Flores, Nicolas, Randrian, Violaine, Ferru, Aurélie, Haineaux, Paul-Arthur, Goujon, Jean-Michel, Karayan-Tapon, Lucie, Tougeron, David

“…There is no robust predictor of response to chemotherapy (CT) in unresectable pancreatic adenocarcinomas (UPA). The objective of the KRASCIPANC study was to…”
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Epithelial colonization by gut dendritic cells promotes their functional diversification by Rivera, Claudia A., Randrian, Violaine, Richer, Wilfrid, Gerber-Ferder, Yohan, Delgado, Maria-Graciela, Chikina, Aleksandra S., Frede, Annika, Sorini, Chiara, Maurin, Mathieu, Kammoun-Chaari, Hana, Parigi, Sara M., Goudot, Christel, Cabeza-Cabrerizo, Mar, Baulande, Sylvain, Lameiras, Sonia, Guermonprez, Pierre, Reis e Sousa, Caetano, Lecuit, Marc, Moreau, Hélène D., Helft, Julie, Vignjevic, Danijela Matic, Villablanca, Eduardo J., Lennon-Duménil, Ana-Maria

“…Dendritic cells (DCs) patrol tissues and transport antigens to lymph nodes to initiate adaptive immune responses. Within tissues, DCs constitute a complex cell…”
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Analysis of fruquintinib adverse events of special interest from phase 3 of the FRESCO-2 study by Eng, Cathy, Dasari, Arvind, Lonardi, Sara, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto F., Yao, James C., Garcia-Alfonso, Pilar, Kocsis, Judit, Cubillo, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Yang, Zhao, Guevara, Ferdinand M., Schelman, William R., Tabernero, Josep

“…3601 Background: Fruquintinib (F) is a highly selective and potent inhibitor of VEGFRs-1, -2 & -3 designed with improved kinase selectivity to minimize…”
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Subgroup analyses of safety and efficacy by number and types of prior lines of treatment in FRESCO-2, a global phase III study of fruquintinib in patients with refractory metastatic colorectal cancer by Dasari, Arvind, Lonardi, Sara, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto F., Yao, James C., Garcia-Alfonso, Pilar, Kocsis, Judit, Cubillo, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Yang, Zhao, Pallai, Rajash, Carton, Iris, Tabernero, Josep, Eng, Cathy

“…3604 Background: Effective treatment options are limited for patients (pts) with refractory metastatic colorectal cancer (mCRC). Fruquintinib (F), a highly…”
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Health-related quality of life (HRQoL) associated with fruquintinib in the global phase 3, placebo-controlled, double-blind FRESCO-2 study by Sobrero, Alberto F., Dasari, Arvind, Lonardi, Sara, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Yao, James C., Garcia-Alfonso, Pilar, Kocsis, Judit, Cubillo, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Yang, Zhao, Schelman, William R., Kania, Marek K., Tabernero, Josep, Eng, Cathy

“…67 Background: The global phase 3 FRESCO-2 study, (NCT04322539) demonstrated that fruquintinib (F) vs placebo (P) significantly improved OS (HR=0.66 [95% CI:…”
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Endoscopy to Diagnose and Prevent Digestive Cancers in Lynch Syndrome by Olivier, Raphael, Randrian, Violaine, Tougeron, David, Saurin, Jean-Christophe

“…Lynch syndrome patients could benefit from various recommendations to prevent digestive cancers. In this review, we summarize the criteria to identify Lynch…”
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Prognostic factors of colorectal cancer patients with brain metastases by Roussille, Pauline, Auvray, Marie, Vansteene, Damien, Lecomte, Thierry, Rigault, Eugénie, Maillet, Marianne, Locher, Christophe, Dior, Marie, Hautefeuille, Vincent, Artru, Pascal, Mabro, May, Touchefeu, Yann, Marthey, Lysiane, Moulin, Valérie, Louafi, Samy, Lecaille, Cédric, Chautard, Romain, Lièvre, Astrid, Zaanan, Aziz, Bennouna, Jaafar, Berger, Antoine, Emambux, Sheik, Randrian, Violaine, Tougeron, David

“…•ECOG performance status 0 or 1 is the best prognostic factor.•Single BM and less than 3 chemotherapy lines are also good prognostic factors.•GI-GPA and DS-GPA…”
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FOLFIRI plus BEvacizumab or aFLIbercept after FOLFOX‐bevacizumab failure for COlorectal cancer (BEFLICO): An AGEO multicenter study by Torregrosa, Cécile, Pernot, Simon, Vaflard, Pauline, Perret, Audrey, Tournigand, Christophe, Randrian, Violaine, Doat, Solene, Neuzillet, Cindy, Moulin, Valérie, Stouvenot, Morgane, Roth, Gael, Darbas, Tiffany, Auberger, Benjamin, Godet, Tiphaine, Jaffrelot, Marion, Lambert, Aurélien, Dubreuil, Olivier, Gluszak, Cassandre, Bernard‐Tessier, Alice, Turpin, Anthony, Palmieri, Lola‐Jade, Bouche, Olivier, Goujon, Gael, Lecomte, Thierry, Sefrioui, David, Locher, Christophe, Grados, Lucien, Gignoux, Pauline, Trager, Stéphanie, Nassif, Elise, Saint, Angélique, Hammel, Pascal, Lecaille, Cédric, Bureau, Mathilde, Perrier, Marine, Botsen, Damien, Bourgeois, Vincent, Taieb, Julien, Auclin, Edouard

“…After failure of first line FOLFOX‐bevacizumab for metastatic colorectal cancer (mCRC), adding either bevacizumab or aflibercept to second‐line FOLFIRI…”
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Prognosis and chemosensitivity of non-colorectal alimentary tract cancers with microsatellite instability by Boyer, Claire, Sefrioui, David, Cohen, Romain, Chautard, Romain, Perrier, Marine, Lebrun, Hugo, Goujon, Gael, Hautefeuille, Vincent, Dior, Marie, Walter, Thomas, Mary, Florence, Manfredi, Silvain, Caroli-Bosc, Francois-Xavier, Cervantes, Baptiste, Coriat, Romain, Deluche, Elise, Zaanan, Aziz, Olivier, Raphael, Bouché, Olivier, Piessen, Guillaume, Lecomte, Thierry, Louvet, Christophe, Michel, Pierre, Aparicio, Thomas, André, Thierry, Taieb, Julien, Randrian, Violaine, Tougeron, David

“…Data on outcomes of microsatellite instable and/or mismatch repair deficient (dMMR/MSI) digestive non-colorectal tumors are limited. To evaluate overall…”
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First-line chemotherapy with raltitrexed in metastatic colorectal cancer: an Association des Gastro-entérologues Oncologues (AGEO) multicentre study by Gallois, Claire, Hafliger, Emilie, Auclin, Edouard, Perret, Audrey, Coutzac, Clélia, Turpin, Anthony, Pellat, Anna, Randrian, Violaine, Basile, Debora, Faroux, Roger, Pernot, Simon, Locher, Christophe, Hautefeuille, Vincent, Dubreuil, Olivier, Palmieri, Lola-Jade, Dior, Marie, Artru, Pascal, Taieb, Julien

“…In case of contraindication or intolerance to fluoropyrimidines, raltitrexed is a validated alternative in metastatic colorectal cancer (mCRC), associated or…”
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FFCD 1709-SIRTCI phase II trial: Selective internal radiation therapy plus Xelox, Bevacizumab and Atezolizumab in liver-dominant metastatic colorectal cancer by Randrian, Violaine, Pernot, Simon, Le Malicot, Karine, Catena, Vittorio, Baumgaertner, Isabelle, Tacher, Vania, Forestier, Julien, Hautefeuille, Vincent, Tabouret-Viaud, Claire, Gagnaire, Alice, Mitry, Emmanuel, Guiu, Boris, Aparicio, Thomas, Smith, Denis, Dhomps, Anthony, Tasu, Jean-Pierre, Perdrisot, Rémy, Edeline, Julien, Capron, Claude, Cheze-Le Rest, Catherine, Emile, Jean-François, Laurent-Puig, Pierre, Bejan-Angoulvant, Theodora, Sokol, Harry, Lepage, Come, Taieb, Julien, Tougeron, David

“…Immune checkpoint inhibitors (ICI) have high efficacy in metastatic colorectal cancer (mCRC) with microsatellite instability (MSI) but not in microsatellite…”
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