Search Results - "Randon, Giovanni"

Variant allele frequency in baseline circulating tumour DNA to measure tumour burden and to stratify outcomes in patients with RAS wild-type metastatic colorectal cancer: a translational objective of the Valentino study by Manca, Paolo, Corallo, Salvatore, Lonardi, Sara, Fucà, Giovanni, Busico, Adele, Leone, Alberto Giovanni, Corti, Francesca, Antoniotti, Carlotta, Procaccio, Letizia, Smiroldo, Valeria, Ratti, Margherita, Murialdo, Roberto, Racca, Patrizia, Pagani, Filippo, Randon, Giovanni, Martinetti, Antonia, Sottotetti, Elisa, Prisciandaro, Michele, Ambrosini, Margherita, Raimondi, Alessandra, Morano, Federica, Pietrantonio, Filippo

“…Introduction In patients with metastatic colorectal cancer (mCRC), baseline circulating tumour DNA (ctDNA) variant allele fraction (VAF) might serve as a…”
Get full text

The Landscape of Actionable Gene Fusions in Colorectal Cancer by Pagani, Filippo, Randon, Giovanni, Guarini, Vincenzo, Raimondi, Alessandra, Prisciandaro, Michele, Lobefaro, Riccardo, Di Bartolomeo, Maria, Sozzi, Gabriella, de Braud, Filippo, Gasparini, Patrizia, Pietrantonio, Filippo

“…The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a…”
Get full text

The Pan-Immune-Inflammation Value in Patients with Metastatic Melanoma Receiving First-Line Therapy by Fucà, Giovanni, Beninato, Teresa, Bini, Marta, Mazzeo, Laura, Di Guardo, Lorenza, Cimminiello, Carolina, Randon, Giovanni, Apollonio, Giulia, Bisogno, Ilaria, Del Vecchio, Marta, Lauria Pantano, Claudia, Di Nicola, Massimo, de Braud, Filippo, Del Vecchio, Michele

“…Background Since a non-negligible fraction of patients with metastatic melanoma does not experience long-term disease control, even with immunotherapy and…”
Get full text

The Evaluation of Response to Immunotherapy in Metastatic Renal Cell Carcinoma: Open Challenges in the Clinical Practice by Raimondi, Alessandra, Randon, Giovanni, Sepe, Pierangela, Claps, Melanie, Verzoni, Elena, de Braud, Filippo, Procopio, Giuseppe

“…Immunotherapy has changed the therapeutic scenario of metastatic renal cell carcinoma (mRCC), however the evaluation of disease response to immune-checkpoint…”
Get full text

Prognostic impact of ATM mutations in patients with metastatic colorectal cancer by Randon, Giovanni, Fucà, Giovanni, Rossini, Daniele, Raimondi, Alessandra, Pagani, Filippo, Perrone, Federica, Tamborini, Elena, Busico, Adele, Peverelli, Giorgia, Morano, Federica, Niger, Monica, Antista, Maria, Corallo, Salvatore, Saggio, Serena, Borelli, Beatrice, Zucchelli, Gemma, Milione, Massimo, Pruneri, Giancarlo, Di Bartolomeo, Maria, Falcone, Alfredo, de Braud, Filippo, Cremolini, Chiara, Pietrantonio, Filippo

“…Tumors bearing homologous recombination deficiency are extremely sensitive to DNA double strand breaks induced by several chemotherapeutic agents. ATM gene,…”
Get full text

EPSILoN: A Prognostic Score for Immunotherapy in Advanced Non-Small-Cell Lung Cancer: A Validation Cohort by Prelaj, Arsela, Ferrara, Roberto, Rebuzzi, Sara Elena, Proto, Claudia, Signorelli, Diego, Galli, Giulia, De Toma, Alessandro, Randon, Giovanni, Pagani, Filippo, Viscardi, Giuseppe, Brambilla, Marta, Trevisan, Benedetta, Ganzinelli, Monica, Martinetti, Antonia, Gallucci, Rosaria, Di Mauro, Rosa Maria, Molino, Giuliano, Zilembo, Nicoletta, Torri, Valter, de Braud, Filippo Maria, Garassino, Marina Chiara, Lo Russo, Giuseppe

“…Beyond programmed death ligand 1 (PD-L1), no other biomarkers for immunotherapy are used in daily practice. We previously created EPSILoN (Eastern Cooperative…”
Get full text

Assessing the safety and activity of cabozantinib combined with lanreotide in gastroenteropancreatic and thoracic neuroendocrine tumors: rationale and protocol of the phase II LOLA trial by Corti, Francesca, Brizzi, Maria Pia, Amoroso, Vito, Giuffrida, Dario, Panzuto, Francesco, Campana, Davide, Prinzi, Natalie, Milione, Massimo, Cascella, Tommaso, Spreafico, Carlo, Randon, Giovanni, Oldani, Simone, Leporati, Rita, Scotto, Giulia, Pulice, Iolanda, Stocchetti, Benedetta Lombardi, Porcu, Luca, Coppa, Jorgelina, Di Bartolomeo, Maria, de Braud, Filippo, Pusceddu, Sara

“…Abstract Background Well-differentiated (WD) neuroendocrine tumors (NETs) are a group of rare neoplasms with limited therapeutic options. Cabozantinib is an…”
Get full text

Systemic doxycycline for pre-emptive treatment of anti-EGFR-related skin toxicity in patients with metastatic colorectal cancer receiving first-line panitumumab-based therapy: a post hoc analysis of the Valentino study by Raimondi, Alessandra, Corallo, Salvatore, Lonardi, Sara, Antoniotti, Carlotta, Rimassa, Lorenza, Amatu, Alessio, Tampellini, Marco, Racca, Patrizia, Murialdo, Roberto, Clavarezza, Matteo, Zaniboni, Alberto, Toscano, Giuseppe, Tomasello, Gianluca, Petrelli, Fausto, Antonuzzo, Lorenzo, Giordano, Monica, Cinieri, Saverio, Longarini, Raffaella, Niger, Monica, Antista, Maria, Ambrosini, Margherita, Pagani, Filippo, Prisciandaro, Michele, Randon, Giovanni, de Braud, Filippo, Di Bartolomeo, Maria, Pietrantonio, Filippo, Morano, Federica

“…Introduction The combination of anti-EGFRs and doublet chemotherapy is considered the optimal upfront option for patients with RAS / BRAF wild-type left-sided…”
Get full text

Body mass index (BMI) and outcome of metastatic melanoma patients receiving targeted therapy and immunotherapy: a multicenter international retrospective study by Rutkowski, Piotr, Indini, Alice, De Luca, Matilde, Merelli, Barbara, Mariuk-Jarema, Anna, Teterycz, Pawel, Rogala, Pawel, Lugowska, Iwona, Cybulska-Stopa, Bożena, Labianca, Alice, Di Guardo, Lorenza, Del Vecchio, Michele, Pigozzo, Jacopo, Randon, Giovanni, Corti, Francesca, Tondini, Carlo Alberto, Rulli, Eliana, Mandala, Mario

“…BackgroundObesity is a risk factor for malignancy; however, its prognostic role in patients with metastatic melanoma is controversial. We aim to investigate…”
Get full text

Biomarker Landscape in Neuroendocrine Tumors With High-Grade Features: Current Knowledge and Future Perspective by Prisciandaro, Michele, Antista, Maria, Raimondi, Alessandra, Corti, Francesca, Morano, Federica, Centonze, Giovanni, Sabella, Giovanna, Mangogna, Alessandro, Randon, Giovanni, Pagani, Filippo, Prinzi, Natalie, Niger, Monica, Corallo, Salvatore, Castiglioni di Caronno, Erica, Massafra, Marco, Bartolomeo, Maria Di, de Braud, Filippo, Milione, Massimo, Pusceddu, Sara

“…Neuroendocrine tumors (NETs) are classified based on morphology and are graded based on their proliferation rate as either well-differentiated low-grade (G1)…”
Get full text

Non-invasive CT radiomic biomarkers predict microsatellite stability status in colorectal cancer: a multicenter validation study by Bodalal, Zuhir, Hong, Eun Kyoung, Trebeschi, Stefano, Kurilova, Ieva, Landolfi, Federica, Bogveradze, Nino, Castagnoli, Francesca, Randon, Giovanni, Snaebjornsson, Petur, Pietrantonio, Filippo, Lee, Jeong Min, Beets, Geerard, Beets-Tan, Regina

“…Background Microsatellite instability (MSI) status is a strong predictor of response to immunotherapy of colorectal cancer. Radiogenomic approaches promise the…”
Get full text

Outcomes and a prognostic classifier in patients with microsatellite instability-high metastatic gastric cancer receiving PD-1 blockade by Randon, Giovanni, Aoki, Yu, Cohen, Romain, Provenzano, Leonardo, Nasca, Vincenzo, Klempner, Samuel J, Maron, Steven B, Cerantola, Riccardo, Chao, Joseph, Fornaro, Lorenzo, Ferrari Bravo, Walter, Ghelardi, Filippo, Ambrosini, Margherita, Manca, Paolo, Salati, Massimiliano, Kawazoe, Akihito, Zhu, Valerie, Cowzer, Darren, Genovesi, Virginia, Lonardi, Sara, Shitara, Kohei, André, Thierry, Pietrantonio, Filippo

“…BackgroundSubgroup analyses of randomized trials suggest the superiority of immune checkpoint inhibitor-based therapy over chemotherapy in patients with…”
Get full text

Metformin: a modulator of bevacizumab activity in cancer? A case report by Indraccolo, Stefano, Randon, Giovanni, Zulato, Elisabetta, Nardin, Margherita, Aliberti, Camillo, Pomerri, Fabio, Casarin, Alessandra, Nicoletto, Maria Ornella

“…Recurrent type I endometrial cancer ( EC ) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody,…”
Get full text

SPARC Is a New Myeloid-Derived Suppressor Cell Marker Licensing Suppressive Activities by Sangaletti, Sabina, Talarico, Giovanna, Chiodoni, Claudia, Cappetti, Barbara, Botti, Laura, Portararo, Paola, Gulino, Alessandro, Consonni, Francesca Maria, Sica, Antonio, Randon, Giovanni, Di Nicola, Massimo, Tripodo, Claudio, Colombo, Mario P

“…Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge…”
Get full text

Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer by Randon, Giovanni, Pietrantonio, Filippo

“…Summary Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic…”
Get full text

MGMT Promoter Methylation as a Target In Metastatic Colorectal Cancer: Rapid Turnover and Use of Folates Alter its Study-Response by Randon, Giovanni, Pagani, Filippo, Pietrantonio, Filippo

Get full text

Immune-related adverse events correlate with improved survival in patients undergoing anti-PD1 immunotherapy for metastatic melanoma by Indini, Alice, Di Guardo, Lorenza, Cimminiello, Carolina, Prisciandaro, Michele, Randon, Giovanni, De Braud, Filippo, Del Vecchio, Michele

“…Background Therapeutic chances for metastatic melanoma have consistently changed over the last years with the advent of antibodies targeting the programmed…”
Get full text

Biomarker-guided implementation of the old drug temozolomide as a novel treatment option for patients with metastatic colorectal cancer by Pietrantonio, Filippo, Randon, Giovanni, Romagnoli, Dario, Di Donato, Samantha, Benelli, Matteo, de Braud, Filippo

“…•MGMT promoter methylation is observed in up to 40% of colorectal tumors.•Activity of temozolomide in MGMT methylated metastatic colorectal cancer is…”
Get full text

Temozolomide Followed by Combination With Low-Dose Ipilimumab and Nivolumab in Patients With Microsatellite-Stable, O 6 -Methylguanine-DNA Methyltransferase-Silenced Metastatic Colorectal Cancer: The MAYA Trial by Morano, Federica, Raimondi, Alessandra, Pagani, Filippo, Lonardi, Sara, Salvatore, Lisa, Cremolini, Chiara, Murgioni, Sabina, Randon, Giovanni, Palermo, Federica, Antonuzzo, Lorenzo, Pella, Nicoletta, Racca, Patrizia, Prisciandaro, Michele, Niger, Monica, Corti, Francesca, Bergamo, Francesca, Zaniboni, Alberto, Ratti, Margherita, Palazzo, Michele, Cagnazzo, Celeste, Calegari, Maria Alessandra, Marmorino, Federica, Capone, Iolanda, Conca, Elena, Busico, Adele, Brich, Silvia, Tamborini, Elena, Perrone, Federica, Di Maio, Massimo, Milione, Massimo, Di Bartolomeo, Maria, de Braud, Filippo, Pietrantonio, Filippo

“…This is a multicenter, single-arm phase II trial evaluating the efficacy and safety of an immune-sensitizing strategy with temozolomide priming followed by a…”
Get full text

RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancer by Elez, Elena, Ros, Javier, Fernández, Jose, Villacampa, Guillermo, Moreno-Cárdenas, Ana Belén, Arenillas, Carlota, Bernatowicz, Kinga, Comas, Raquel, Li, Shanshan, Kodack, David Philip, Fasani, Roberta, Garcia, Ariadna, Gonzalo-Ruiz, Javier, Piris-Gimenez, Alejandro, Nuciforo, Paolo, Kerr, Grainne, Intini, Rossana, Montagna, Aldo, Germani, Marco Maria, Randon, Giovanni, Vivancos, Ana, Smits, Ron, Graus, Diana, Perez-Lopez, Raquel, Cremolini, Chiara, Lonardi, Sara, Pietrantonio, Filippo, Dienstmann, Rodrigo, Tabernero, Josep, Toledo, Rodrigo A.

“…Anti-BRAF/EGFR therapy was recently approved for the treatment of metastatic BRAF V600E colorectal cancer (mCRC BRAF-V600E ). However, a large fraction of…”
Get full text