Search Results - "Randolph, Nikole"

Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors by Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A, Laird, Ellen R, Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J, Choo, Edna F, Dinkel, Victoria, Feng, Bainian, Gloor, Susan L, Gould, Stephen E, Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D, Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J, Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T, Shrag, Michael, Song, Kyung, Sturgis, Hillary L, Voegtli, Walter C, Wen, Zhaoyang, Willis, Brandon S, Woessner, Richard D, Wu, Wen-I, Young, Wendy B, Grina, Jonas

“…The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using…”
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Non-oxime pyrazole based inhibitors of B-Raf kinase by Newhouse, Bradley J., Hansen, Joshua D., Grina, Jonas, Welch, Mike, Topalov, George, Littman, Nicole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Laird, Ellen R., Brandhuber, Barbara J., Vigers, Guy, Morales, Tony, Woessner, Rich, Randolph, Nikole, Lyssikatos, Joseph, Olivero, Alan

“…The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown…”
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Potent and selective pyrazole-based inhibitors of B-Raf kinase by Hansen, Joshua D., Grina, Jonas, Newhouse, Brad, Welch, Mike, Topalov, George, Littman, Nicole, Callejo, Michele, Gloor, Susan, Martinson, Matthew, Laird, Ellen, Brandhuber, Barbara J., Vigers, Guy, Morales, Tony, Woessner, Rich, Randolph, Nikole, Lyssikatos, Joseph, Olivero, Alan

“…We report herein a series of substituted pyrazoles as inhibitors of B-Raf kinase. Through structure–activity relationship studies, cellular potency,…”
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Non-oxime inhibitors of B-Raf(V600E) kinase by Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

“…The development of inhibitors of B-Raf(V600E) serine-threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and ADME…”
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The Discovery of furo[2,3- c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors by Buckmelter, Alex J., Ren, Li, Laird, Ellen R., Rast, Bryson, Miknis, Greg, Wenglowsky, Steve, Schlachter, Stephen, Welch, Mike, Tarlton, Eugene, Grina, Jonas, Lyssikatos, Joseph, Brandhuber, Barbara J., Morales, Tony, Randolph, Nikole, Vigers, Guy, Martinson, Matthew, Callejo, Michele

“…Virtual and high-throughput screening identified imidazo[1,2- a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial…”
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Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors by Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A, Laird, Ellen R, Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J, Choo, Edna F, Dinkel, Victoria, Feng, Bainian, Gloor, Susan L, Gould, Stephen E, Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D, Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J, Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T, Shrag, Michael, Song, Kyung, Sturgis, Hillary L, Voegtli, Walter C, Wen, Zhaoyang, Willis, Brandon S, Woessner, Richard D, Wu, Wen-I, Young, Wendy B, Grina, Jonas

“…The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using…”
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Non-oxime inhibitors of B-Raf super(V600E) kinase by Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

“…The development of inhibitors of B-Raf super(V600E) serine-threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and…”
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Non-oxime inhibitors of B-Raf V600E kinase by Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J., Ely, Robert J., Schlachter, Stephen, Laird, Ellen R., Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J., Vigers, Guy, Morales, Tony, Voegtli, Walter C., Lyssikatos, Joseph

“…Inhibitors of B-Raf V600E kinase are reported for which indanone oximes are replaced with tricyclic pyrazoles and indazoles. The development of inhibitors of…”
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Abstract B254: Extended target-coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo by Humphries, Michael J., von Carlowitz, Ira, Le Huerou, Yvan, Randolph, Nikole, Mohr, Peter J., Wang, Bin, Lyon, Michael A., Gunawardana, Indrani, Chicarelli, Mark, Blake, Jim F., Schrag, Michael L., Winski, Shannon L., Wallace, Eli

“…Abstract Loss of coordination between cell cycle checkpoints and DNA damage repair is a fundamental feature tumor cells rely on for unregulated growth and…”
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Non-oxime inhibitors of B-Rafⱽ⁶⁰⁰ᴱ kinase by Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

“…The development of inhibitors of B-Rafⱽ⁶⁰⁰ᴱ serine–threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and ADME…”
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Pyrazolopyridine Inhibitors of B-Raf V600E . Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors by Wenglowsky, Steve, Ren, Li, Ahrendt, Kateri A., Laird, Ellen R., Aliagas, Ignacio, Alicke, Bruno, Buckmelter, Alex J., Choo, Edna F., Dinkel, Victoria, Feng, Bainian, Gloor, Susan L., Gould, Stephen E., Gross, Stefan, Gunzner-Toste, Janet, Hansen, Joshua D., Hatzivassiliou, Georgia, Liu, Bonnie, Malesky, Kim, Mathieu, Simon, Newhouse, Brad, Raddatz, Nicholas J., Ran, Yingqing, Rana, Sumeet, Randolph, Nikole, Risom, Tyler, Rudolph, Joachim, Savage, Scott, Selby, LeAnn T., Shrag, Michael, Song, Kyung, Sturgis, Hillary L., Voegtli, Walter C., Wen, Zhaoyang, Willis, Brandon S., Woessner, Richard D., Wu, Wen-I, Young, Wendy B., Grina, Jonas

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