Search Results - "Randolph, Mark A."

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment by Kfoury, Youmna, Baryawno, Ninib, Severe, Nicolas, Mei, Shenglin, Gustafsson, Karin, Hirz, Taghreed, Brouse, Thomas, Scadden, Elizabeth W., Igolkina, Anna A., Kokkaliaris, Konstantinos, Choi, Bryan D., Barkas, Nikolas, Randolph, Mark A., Shin, John H., Saylor, Philip J., Scadden, David T., Sykes, David B., Kharchenko, Peter V.

“…Bone metastases are devastating complications of cancer. They are particularly common in prostate cancer (PCa), represent incurable disease, and are refractory…”
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Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery by Berkane, Yanis, Cascales, Juan Pedro, Roussakis, Emmanuel, Lellouch, Alexandre G., Slade, Julian, Bertheuil, Nicolas, Randolph, Mark A., Cetrulo, Curtis L., Evans, Conor L., Uygun, Korkut

“…Continuous oxygenation monitoring of machine-perfused organs or transposed autologous tissue is not currently implemented in clinical practice. Oxygenation is…”
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Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition by Sridhar, Balaji V., Brock, John L., Silver, Jason S., Leight, Jennifer L., Randolph, Mark A., Anseth, Kristi S.

“…Healing articular cartilage remains a significant clinical challenge because of its limited self‐healing capacity. While delivery of autologous chondrocytes to…”
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VCA supercooling in a swine partial hindlimb model by Berkane, Yanis, Filz von Reiterdank, Irina, Tawa, Pierre, Charlès, Laura, Goutard, Marion, Dinicu, Antonia T., Toner, Mehmet, Bertheuil, Nicolas, Mink van der Molen, Aebele B., Coert, J. Henk, Lellouch, Alexandre G., Randolph, Mark A., Cetrulo, Curtis L., Uygun, Korkut

“…Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major…”
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Photosealed Neurorrhaphy Using Autologous Tissue by Rossi, Nicolò, Bejar-Chapa, Maria, Giorgino, Riccardo, Scott, Benjamin B, Kostyra, David M, Peretti, Giuseppe M, Randolph, Mark A, Redmond, Robert W

“…Photochemical sealing of a nerve wrap over the repair site isolates and optimizes the regenerating nerve microenvironment. To facilitate clinical adoption of…”
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Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation by Goutard, Marion, Tawa, Pierre, Berkane, Yanis, Andrews, Alec R, Pendexter, Casie A, de Vries, Reinier J, Pozzo, Victor, Romano, Golda, Lancia, Hyshem H, Filz von Reiterdank, Irina, Bertheuil, Nicolas, Rosales, Ivy A, How, Ira Doressa Anne L, Randolph, Mark A, Lellouch, Alexandre G, Cetrulo, Jr, Curtis L, Uygun, Korkut

“…The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can…”
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Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks by Burdick, Jason A, Chung, Cindy, Jia, Xinqiao, Randolph, Mark A, Langer, Robert

“…Hyaluronic acid is a natural polysaccharide found abundantly throughout the body with many desirable properties for application as a biomaterial, including…”
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Acellular Nipple Scaffold Development, Characterization, and Preliminary Biocompatibility Assessment in a Swine Model by Oganesyan, Ruben V., Lellouch, Alexandre G., Acun, Aylin, Lupon, Elise, Taveau, Corentin B., Burlage, Laura C., Lantieri, Laurent A., Randolph, Mark A., Cetrulo, Curtis L., Uygun, Basak E.

“…The standard in nipple reconstruction remains the autologous skin flap. Unfortunately, the results are not satisfying, with up to 75% loss of nipple projection…”
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Mechanobiological Interactions between Dynamic Compressive Loading and Viscoelasticity on Chondrocytes in Hydrazone Covalent Adaptable Networks for Cartilage Tissue Engineering by Richardson, Benjamin M., Walker, Cierra J., Maples, Mollie M., Randolph, Mark A., Bryant, Stephanie J., Anseth, Kristi S.

“…Mechanobiological cues influence chondrocyte biosynthesis and are often used in tissue engineering applications to improve the repair of articular cartilage in…”
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Comprehensive evaluation of peripheral nerve regeneration in the acute healing phase using tissue clearing and optical microscopy in a rodent model by Jung, Yookyung, Ng, Joanna H, Keating, Cameron P, Senthil-Kumar, Prabhu, Zhao, Jie, Randolph, Mark A, Winograd, Jonathan M, Evans, Conor L

“…Peripheral nerve injury (PNI), a common injury in both the civilian and military arenas, is usually associated with high healthcare costs and with patients…”
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Comparative Analysis of Processing Methods in Fat Grafting by Salinas, Harry M., Broelsch, G. Felix, Fernandes, Justin R., McCormack, Michael C., Meppelink, Amanda M., Randolph, Mark A., Colwell, Amy S., Austen, William G.

“…Centrifugation is a popular processing method, with an unclear mechanism of action. Hypotheses include fat concentration, reduced inflammatory response by…”
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The tissue-engineered auricle: past, present, and future by Bichara, David A, O'Sullivan, Niamh-Anna, Pomerantseva, Irina, Zhao, Xing, Sundback, Cathryn A, Vacanti, Joseph P, Randolph, Mark A

“…The reconstruction, repair, and regeneration of the external auricular framework continue to be one of the greatest challenges in the field of tissue…”
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Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism by Lellouch, Alexandre G, Andrews, Alec R, Saviane, Gaelle, Ng, Zhi Yang, Schol, Ilse M, Goutard, Marion, Gama, Amon-Ra, Rosales, Ivy A, Colvin, Robert B, Lantieri, Laurent A, Randolph, Mark A, Benichou, Gilles, Cetrulo, Jr, Curtis L

“…Vascularized composite allografts (VCAs) allow reconstruction of devastating injuries and amputations, yet require lifelong immunosuppression that is…”
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Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study by Berkane, Yanis, Lellouch, Alexandre G, Goudot, Guillaume, Shamlou, Austin, Filz von Reiterdank, Irina, Goutard, Marion, Tawa, Pierre, Girard, Paul, Bertheuil, Nicolas, Uygun, Basak E, Randolph, Mark A, Duisit, Jérôme, Cetrulo, Jr, Curtis L, Uygun, Korkut

“…Machine perfusion has developed rapidly since its first use in solid organ transplantation. Likewise, reconstructive surgery has kept pace, and ex vivo…”
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The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization by Berkane, Yanis, Kostyra, David M, Chrelias, Theodoros, Randolph, Mark A, Lellouch, Alexandre G, Cetrulo, Jr, Curtis L, Uygun, Korkut, Uygun, Basak E, Bertheuil, Nicolas, Duisit, Jérôme

“…Autonomization is a physiological process allowing a flap to develop from the reconstructed wound bed. This phenomenon has been used since the early…”
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Laser Ablation Facilitates Implantation of Dynamic Self-Regenerating Cartilage for Articular Cartilage Regeneration by Fan, Yingfang, Guastaldi, Fernando P S, Runyan, Gem, Wang, Ying, Farinelli, William A, Randolph, Mark A, Redmond, Robert W

“…This study investigated a novel strategy for improving regenerative cartilage outcomes. It combines fractional laser treatment with the implantation of…”
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The impact of liposuction cannula size on adipocyte viability by Kirkham, John C, Lee, Jeffrey H, Medina, 3rd, Miguel A, McCormack, Michael C, Randolph, Mark A, Austen, Jr, William G

“…Autologous fat transfer ("fat grafting") is widely used in cosmetic and reconstructive surgery, but long-term outcomes remain inconsistent. Each step in the…”
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The efficacy of vitamin E in preventing arthrofibrosis after joint replacement by Fan, Yingfang, Yuh, Jean, Lekkala, Sashank, Asik, Mehmet D., Thomson, Andrew, McCanne, Madeline, Randolph, Mark A., Chen, Antonia F., Oral, Ebru

“…Background Arthrofibrosis is a joint disorder characterized by excessive scar formation in the joint tissues. Vitamin E is an antioxidant with potential…”
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Ear-Shaped Stable Auricular Cartilage Engineered from Extensively Expanded Chondrocytes in an Immunocompetent Experimental Animal Model by Pomerantseva, Irina, Bichara, David A, Tseng, Alan, Cronce, Michael J, Cervantes, Thomas M, Kimura, Anya M, Neville, Craig M, Roscioli, Nick, Vacanti, Joseph P, Randolph, Mark A, Sundback, Cathryn A

“…Advancement of engineered ear in clinical practice is limited by several challenges. The complex, largely unsupported, three-dimensional auricular neocartilage…”
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Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks by Chung, Cindy, Mesa, John, Randolph, Mark A., Yaremchuk, Michael, Burdick, Jason A.

“…The objective of this study was to determine how changes in the network structure and properties of hyaluronic acid (HA) hydrogels, due to variations in the…”
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