Search Results - "Randolph, J"

Recovery after brain injury: mechanisms and principles by Nudo, Randolph J

“…The past 20 years have represented an important period in the development of principles underlying neuroplasticity, especially as they apply to recovery from…”
Get full text

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease by Oliver, Guillermo, Kipnis, Jonathan, Randolph, Gwendalyn J., Harvey, Natasha L.

“…Mammals have two specialized vascular circulatory systems: the blood vasculature and the lymphatic vasculature. The lymphatic vasculature is a unidirectional…”
Get full text

Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey by ElTanbouly, Mohamed A., Noelle, Randolph J.

“…Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is…”
Get full text

Origin and Functions of Tissue Macrophages by Epelman, Slava, Lavine, Kory J., Randolph, Gwendalyn J.

“…Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult…”
Get full text

Monocyte differentiation and antigen-presenting functions by Jakubzick, Claudia V., Randolph, Gwendalyn J., Henson, Peter M.

“…Key Points Constitutively migrating LY6C + monocytes can retain their own properties without differentiating into a bone fide macrophage or dendritic cell…”
Get full text

Postinfarct cortical plasticity and behavioral recovery by NUDO, Randolph J

“…Plasticity phenomena in the cerebral cortex after ischemic injury have been documented repeatedly over the past 2 decades both in animal models and in human…”
Get full text

B7 family checkpoint regulators in immune regulation and disease by Ceeraz, Sabrina, Nowak, Elizabeth C, Noelle, Randolph J

“…Highlights • In the clinic, targeting blocking the CTLA-4 and PD-1 pathway is advantageous in cancer patients. • Preclinical studies show that B7-H4 and B7-H6…”
Get full text

Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program by Brown, Chrysothemis C., Esterhazy, Daria, Sarde, Aurelien, London, Mariya, Pullabhatla, Venu, Osma-Garcia, Ines, al-Bader, Raya, Ortiz, Carla, Elgueta, Raul, Arno, Matthew, de Rinaldis, Emanuele, Mucida, Daniel, Lord, Graham M., Noelle, Randolph J.

“…CD4+ T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages…”
Get full text

Mechanisms for recovery of motor function following cortical damage by Nudo, Randolph J

“…Recent studies of focal injury to the cerebral cortex have demonstrated that the remaining, intact tissue undergoes structural and functional changes that…”
Get full text

Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators by Le Mercier, Isabelle, Lines, J Louise, Noelle, Randolph J

“…In the last two years, clinical trials with blocking antibodies to the negative checkpoint regulators CTLA-4 and PD-1 have rekindled the hope for cancer…”
Get full text

VISTA Regulates the Development of Protective Antitumor Immunity by LE MERCIER, Isabelle, WENNA CHEN, LINES, Janet L, DAY, Maria, JIANNAN LI, SERGENT, Petra, NOELLE, Randolph J, LI WANG

“…V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This…”
Get full text

The Lymphatic System: Integral Roles in Immunity by Randolph, Gwendalyn J, Ivanov, Stoyan, Zinselmeyer, Bernd H, Scallan, Joshua P

“…The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination…”
Get full text

Lymphatic transport of high-density lipoproteins and chylomicrons by Randolph, Gwendalyn J, Miller, Norman E

“…The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in cholesterol transport from cells requires that they readily gain…”
Get full text

VISTA: A novel immunotherapy target for normalizing innate and adaptive immunity by ElTanbouly, Mohamed A., Croteau, Walburga, Noelle, Randolph J., Lines, J. Louise

“…•We discuss the role of VISTA as a negative checkpoint directing both innate and adaptive immunity.•VISTA is broadly expressed on myeloid and T cells, and…”
Get full text

Shaping plasticity to enhance recovery after injury by Dancause, Numa, Nudo, Randolph J

“…The past decade of neuroscience research has provided considerable evidence that the adult brain can undergo substantial reorganization following injury. For…”
Get more information

Immunoregulatory functions of VISTA by Nowak, Elizabeth C., Lines, J. Louise, Varn, Frederick S., Deng, Jie, Sarde, Aurelien, Mabaera, Rodwell, Kuta, Anna, Le Mercier, Isabelle, Cheng, Chao, Noelle, Randolph J.

“…Summary Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials…”
Get full text

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers by Diaz Jr, Luis A., Williams, Richard T., Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert

“…This work on colorectal cancer shows that secondary mutations in KRAS that confer resistance to panitumumab, an anti-EGFR monoclonal antibody, are already…”
Get full text

Cellular sources and immune functions of interleukin-9 by Noelle, Randolph J, Nowak, Elizabeth C

“…Interleukin-9 (IL-9) has recently entered the limelight owing to the discovery that it can be produced by multiple T helper cell subsets. This Progress article…”
Get full text

A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma by Hecht, J. Randolph, Benson, Al B., Vyushkov, Dmitry, Yang, Yingsi, Bendell, Johanna, Verma, Udit

“…Lessons Learned The safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group. The…”
Get full text

A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma by Benson, Al B., Wainberg, Zev A., Hecht, J. Randolph, Vyushkov, Dmitry, Dong, Hua, Bendell, Johanna, Kudrik, Fred

“…Lessons Learned The safety profile in the gemcitabine/simtuzumab group was similar to that in the gemcitabine/placebo group. The addition of simtuzumab to…”
Get full text