Search Results - "Randolph, Gwendalyn J"

Origin and Functions of Tissue Macrophages by Epelman, Slava, Lavine, Kory J., Randolph, Gwendalyn J.

“…Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult…”
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The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease by Oliver, Guillermo, Kipnis, Jonathan, Randolph, Gwendalyn J., Harvey, Natasha L.

“…Mammals have two specialized vascular circulatory systems: the blood vasculature and the lymphatic vasculature. The lymphatic vasculature is a unidirectional…”
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Monocyte differentiation and antigen-presenting functions by Jakubzick, Claudia V., Randolph, Gwendalyn J., Henson, Peter M.

“…Key Points Constitutively migrating LY6C + monocytes can retain their own properties without differentiating into a bone fide macrophage or dendritic cell…”
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The Lymphatic System: Integral Roles in Immunity by Randolph, Gwendalyn J, Ivanov, Stoyan, Zinselmeyer, Bernd H, Scallan, Joshua P

“…The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination…”
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Lymphatic transport of high-density lipoproteins and chylomicrons by Randolph, Gwendalyn J, Miller, Norman E

“…The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in cholesterol transport from cells requires that they readily gain…”
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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation by Lampropoulou, Vicky, Sergushichev, Alexey, Bambouskova, Monika, Nair, Sharmila, Vincent, Emma E., Loginicheva, Ekaterina, Cervantes-Barragan, Luisa, Ma, Xiucui, Huang, Stanley Ching-Cheng, Griss, Takla, Weinheimer, Carla J., Khader, Shabaana, Randolph, Gwendalyn J., Pearce, Edward J., Jones, Russell G., Diwan, Abhinav, Diamond, Michael S., Artyomov, Maxim N.

“…Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying inflammatory macrophage activation. During this process, endogenous…”
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Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes by Jakubzick, Claudia, Gautier, Emmanuel L., Gibbings, Sophie L., Sojka, Dorothy K., Schlitzer, Andreas, Johnson, Theodore E., Ivanov, Stoyan, Duan, Qiaonan, Bala, Shashi, Condon, Tracy, van Rooijen, Nico, Grainger, John R., Belkaid, Yasmine, Ma’ayan, Avi, Riches, David W.H., Yokoyama, Wayne M., Ginhoux, Florent, Henson, Peter M., Randolph, Gwendalyn J.

“…It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C+ monocytes…”
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart by Lavine, Kory J., Epelman, Slava, Uchida, Keita, Weber, Kassandra J., Nichols, Colin G., Schilling, Joel D., Ornitz, David M., Randolph, Gwendalyn J., Mann, Douglas L.

“…Significance This study addresses a fundamentally important and widely debated issue in the field of inflammation, which is why inflammation can be…”
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Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models by Kim, Kyeongdae, Shim, Dahee, Lee, Jun Seong, Zaitsev, Konstantin, Williams, Jesse W, Kim, Ki-Wook, Jang, Man-Young, Seok Jang, Hyung, Yun, Tae Jin, Lee, Seung Hyun, Yoon, Won Kee, Prat, Annik, Seidah, Nabil G, Choi, Jungsoon, Lee, Seung-Pyo, Yoon, Sang-Ho, Nam, Jin Wu, Seong, Je Kyung, Oh, Goo Taeg, Randolph, Gwendalyn J, Artyomov, Maxim N, Cheong, Cheolho, Choi, Jae-Hoon

“…Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the…”
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Liver inflammation abrogates immunological tolerance induced by Kupffer cells by Heymann, Felix, Peusquens, Julia, Ludwig‐Portugall, Isis, Kohlhepp, Marlene, Ergen, Can, Niemietz, Patricia, Martin, Christian, van Rooijen, Nico, Ochando, Jordi C., Randolph, Gwendalyn J., Luedde, Tom, Ginhoux, Florent, Kurts, Christian, Trautwein, Christian, Tacke, Frank

“…The liver is essential for inducing immunological tolerance toward harmless antigens to maintain immune system homeostasis. However, the precise cellular…”
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Enterically derived high-density lipoprotein restrains liver injury through the portal vein by Han, Yong-Hyun, Onufer, Emily J, Huang, Li-Hao, Sprung, Robert W, Davidson, W Sean, Czepielewski, Rafael S, Wohltmann, Mary, Sorci-Thomas, Mary G, Warner, Brad W, Randolph, Gwendalyn J

“…The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the…”
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Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability by Evrard, Solene M., Lecce, Laura, Michelis, Katherine C., Nomura-Kitabayashi, Aya, Pandey, Gaurav, Purushothaman, K-Raman, d’Escamard, Valentina, Li, Jennifer R., Hadri, Lahouaria, Fujitani, Kenji, Moreno, Pedro R., Benard, Ludovic, Rimmele, Pauline, Cohain, Ariella, Mecham, Brigham, Randolph, Gwendalyn J., Nabel, Elizabeth G., Hajjar, Roger, Fuster, Valentin, Boehm, Manfred, Kovacic, Jason C.

“…Endothelial to mesenchymal transition (EndMT) plays a major role during development, and also contributes to several adult cardiovascular diseases…”
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The pancreas anatomy conditions the origin and properties of resident macrophages by Calderon, Boris, Carrero, Javier A, Ferris, Stephen T, Sojka, Dorothy K, Moore, Lindsay, Epelman, Slava, Murphy, Kenneth M, Yokoyama, Wayne M, Randolph, Gwendalyn J, Unanue, Emil R

“…We examine the features, origin, turnover, and gene expression of pancreatic macrophages under steady state. The data distinguish macrophages within distinct…”
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Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia by Wang, Peter L., Yim, Aldrin K. Y., Kim, Ki-Wook, Avey, Denis, Czepielewski, Rafael S., Colonna, Marco, Milbrandt, Jeffrey, Randolph, Gwendalyn J.

“…Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the…”
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Monocyte trafficking in acute and chronic inflammation by Ingersoll, Molly A, Platt, Andrew M, Potteaux, Stephane, Randolph, Gwendalyn J

“…Environmental signals at the site of inflammation mediate rapid monocyte mobilization and dictate differentiation programs whereby these cells give rise to…”
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Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression by Williams, Jesse W., Zaitsev, Konstantin, Kim, Ki-Wook, Ivanov, Stoyan, Saunders, Brian T., Schrank, Patricia R., Kim, Kyeongdae, Elvington, Andrew, Kim, Seung Hyeon, Tucker, Christopher G., Wohltmann, Mary, Fife, Brian T., Epelman, Slava, Artyomov, Maxim N., Lavine, Kory J., Zinselmeyer, Bernd H., Choi, Jae-Hoon, Randolph, Gwendalyn J.

“…Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated…”
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A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages by Buechler, Matthew B., Kim, Ki-Wook, Onufer, Emily J., Williams, Jesse W., Little, Christine C., Dominguez, Claudia X., Li, Qingling, Sandoval, Wendy, Cooper, Jonathan E., Harris, Charles A., Junttila, Melissa R., Randolph, Gwendalyn J., Turley, Shannon J.

“…Tissue-resident macrophages require specific milieus for the maintenance of defining gene-expression programs. Expression of the transcription factor GATA6 is…”
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Nomenclature of monocytes and dendritic cells in blood by Ziegler-Heitbrock, Loems, Ancuta, Petronela, Crowe, Suzanne, Dalod, Marc, Grau, Veronika, Hart, Derek N., Leenen, Pieter J.M., Liu, Yong-Jun, MacPherson, Gordon, Randolph, Gwendalyn J., Scherberich, Juergen, Schmitz, Juergen, Shortman, Ken, Sozzani, Silvano, Strobl, Herbert, Zembala, Marek, Austyn, Jonathan M., Lutz, Manfred B.

“…Monocytes and cells of the dendritic cell lineage circulate in blood and eventually migrate into tissue where they further mature and serve various functions,…”
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Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells by Cifarelli, Vincenza, Appak-Baskoy, Sila, Peche, Vivek S., Kluzak, Andrew, Shew, Trevor, Narendran, Ramkumar, Pietka, Kathryn M., Cella, Marina, Walls, Curtis W., Czepielewski, Rafael, Ivanov, Stoyan, Randolph, Gwendalyn J., Augustin, Hellmut G., Abumrad, Nada A.

“…Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but regulation of lymphatic vessel function and its link to disease…”
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