Search Results - "Randle, Suzanne"

F-box protein interactions with the hallmark pathways in cancer by Randle, Suzanne J, Laman, Heike

“…Abstract F-box proteins (FBP) are the substrate specifying subunit of Skp1-Cul1-FBP (SCF)-type E3 ubiquitin ligases and are responsible for directing the…”
Get full text

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions by Qamar, Seema, Wang, GuoZhen, Randle, Suzanne J., Ruggeri, Francesco Simone, Varela, Juan A., Lin, Julie Qiaojin, Phillips, Emma C., Miyashita, Akinori, Williams, Declan, Ströhl, Florian, Meadows, William, Ferry, Rodylyn, Dardov, Victoria J., Tartaglia, Gian G., Farrer, Lindsay A., Kaminski Schierle, Gabriele S., Kaminski, Clemens F., Holt, Christine E., Fraser, Paul E., Schmitt-Ulms, Gerold, Klenerman, David, Knowles, Tuomas, Vendruscolo, Michele, St George-Hyslop, Peter

“…Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the…”
Get full text

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration by St George-Hyslop, Peter, Lin, Julie Qiaojin, Miyashita, Akinori, Phillips, Emma C., Qamar, Seema, Randle, Suzanne J., Wang, GuoZhen

“…[Display omitted] •Some intrinsically disordered proteins undergo reversible phase separation/gelation.•Reversible phase separation/gelation underpins function…”
Get full text

Structure and Function of Fbxo7/PARK15 in Parkinson's Disease by Randle, Suzanne J, Laman, Heike

“…Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)- type E3 ubiquitin ligase and also having SCF-independent activities…”
Get more information

Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway by Stott, Simon RW, Randle, Suzanne J, Rawi, Sara, Rowicka, Paulina A, Harris, Rebecca, Mason, Bethany, Xia, Jing, Dalley, Jeffrey W, Barker, Roger A, Laman, Heike

“…The field of Parkinson's disease research has been impeded by the absence of animal models that clearly phenocopy the features of this neurodegenerative…”
Get full text

Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression by Randle, Suzanne J, Nelson, David E, Patel, Shachi P, Laman, Heike

“…During the final stages of erythropoiesis, lineage‐restricted progenitors mature over three to five cell divisions, culminating with withdrawal from the cell…”
Get full text

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease by Teixeira, Felipe Roberti, Randle, Suzanne J, Patel, Shachi P, Mevissen, Tycho E T, Zenkeviciute, Grasilda, Koide, Tie, Komander, David, Laman, Heike

“…Fbxo7 is a clinically relevant F-box protein, associated with both cancer and Parkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with…”
Get more information

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins by Nelson, David E., Randle, Suzanne J., Laman, Heike

“…F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases. To date, 69 FBPs have been identified in humans,…”
Get full text

Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27 by Patel, Shachi P., Randle, Suzanne J., Gibbs, Sarah, Cooke, Anne, Laman, Heike

“…G 1 phase cell cycle proteins, such as cyclin-dependent kinase 6 (Cdk6) and its activating partners, the D-type cyclins, are important regulators of T-cell…”
Get full text

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors by Chou, David B., Furlong, Brooke A., Posey, Ryan R., Kyprianou, Christos, O’Sullivan, Lucy R., David, Rhiannon, Randle, Suzanne J., Polanska, Urszula M., Travers, Jon, Urosevic, Jelena, Hutchinson, John N., Che, Jianwei, Howley, Anna M., Hasserjian, Robert P., Prantil-Baun, Rachelle, Ingber, Donald E.

“…Drug-induced cytopenias are a prevalent and significant issue that worsens clinical outcomes and hinders the effective treatment of cancer. While reductions in…”
Get full text

The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway by Spagnol, Valentine, Oliveira, Caio A.B., Randle, Suzanne J., Passos, Patrícia M.S., Correia, Camila R.S.T.B., Simaroli, Natália B., Oliveira, Joice S., Mevissen, Tycho E.T., Medeiros, Ana Carla, Gomes, Marcelo D., Komander, David, Laman, Heike, Teixeira, Felipe Roberti

“…Ubiquitously eXpressed Transcript isoform 2 (UXTV2) is a prefoldin-like protein involved in NF-κB signaling, apoptosis, and the androgen and estrogen response…”
Get full text

Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells by Meziane, El Kahina, Randle, Suzanne J, Nelson, David E, Lomonosov, Mikhail, Laman, Heike

“…Fbxo7 is an unusual F-box protein because most of its interacting proteins are not substrates for ubiquitin-mediated degradation. Fbxo7 directly binds p27 and…”
Get full text

Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis by Lomonosov, Mikhail, Meziane, El Kahina, Ye, Hongtao, Nelson, David E, Randle, Suzanne J, Laman, Heike

“…Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated…”
Get full text

The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy by Burchell, Victoria S, Nelson, David E, Sanchez-Martinez, Alvaro, Delgado-Camprubi, Marta, Ivatt, Rachael M, Pogson, Joe H, Randle, Suzanne J, Wray, Selina, Lewis, Patrick A, Houlden, Henry, Abramov, Andrey Y, Hardy, John, Wood, Nicholas W, Whitworth, Alexander J, Laman, Heike, Plun-Favreau, Helene

“…Mutations in the gene encoding the F-box domain–containing protein Fbxo7 are genetically associated to an autosomal recessive form of early-onset Parkinson's…”
Get full text

Overexpression of Wild-Type Murine Tau Results in Progressive Tauopathy and Neurodegeneration by Adams, Stephanie J, Crook, Richard J.P, DeTure, Michael, Randle, Suzanne J, Innes, Amy E, Yu, Xin Z, Lin, Wen-Lang, Dugger, Brittany N, McBride, Melinda, Hutton, Mike, Dickson, Dennis W, McGowan, Eileen

“…Here, we describe the generation and characterization of a novel tau transgenic mouse model (mTau) that overexpresses wild-type murine tau protein by twofold…”
Get full text

Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells by Meziane, El Kahina, Randle, Suzanne J., Nelson, David E., Lomonosov, Mikhail, Laman, Heike

Get full text

A Conserved Requirement for Fbxo7 During Male Germ Cell Cytoplasmic Remodeling by Rathje, Claudia C., Randle, Suzanne J., Al Rawi, Sara, Skinner, Benjamin M., Nelson, David E., Majumdar, Antara, Johnson, Emma E. P., Bacon, Joanne, Vlazaki, Myrto, Affara, Nabeel A., Ellis, Peter J., Laman, Heike

“…Fbxo7 is the substrate-recognition subunit of an SCF-type ubiquitin E3 ligase complex. It has physiologically important functions in regulating mitophagy,…”
Get full text

Analysis of the FBXO7 promoter reveals overlapping Pax5 and c-Myb binding sites functioning in B cells by Harris, Rebecca, Randle, Suzanne, Laman, Heike

“…Fbxo7 is a key player in the differentiation and function of numerous blood cell types, and in neurons, oligodendrocytes and spermatocytes. In an effort to…”
Get full text

P2-172: Wild-type mouse tau transgenic model: Halfway to a complete AD model by Adams, Stephanie J, Dugger, Brittany, Innes, Amy, Randle, Suzanne J, Yu, Cindy, Crook, Richard J.P, Hutton, Mike, McGowan, Eileen, Dickson, Dennis W

Get full text

Aβ40 Inhibits Amyloid Deposition In Vivo by Kim, Jungsu, Onstead, Luisa, Randle, Suzanne, Price, Robert, Smithson, Lisa, Zwizinski, Craig, Dickson, Dennis W., Golde, Todd, McGowan, Eileen

“…Numerous studies have established a pivotal role for Aβ42 in Alzheimer's disease (AD) pathogenesis. In contrast, although Aβ40 is the predominant form of…”
Get full text