Search Results - "Randle, Laura E"

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture by Kelly, Ross A, Leedale, Joseph, Harrell, Andy, Beard, Daniel A, Randle, Laura E, Chadwick, Amy E, Webb, Steven D

“…Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in…”
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The Generation, Detection, and Effects of Reactive Drug Metabolites by Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.

“…The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is…”
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The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system by Copple, Ian M., Goldring, Christopher E., Jenkins, Rosalind E., Chia, Alvin J. L., Randle, Laura E., Hayes, John D., Kitteringham, Neil R., Park, B. Kevin

“…The transcription factor Nrf2 regulates the expression of numerous cytoprotective genes in mammalian cells. We have demonstrated previously that acetaminophen…”
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Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines by Fielding, Alistair J., Lukinović, Valentina, Evans, Philip G., Alizadeh‐Shekalgourabi, Said, Bisby, Roger H., Drew, Michael G. B., Male, Verity, Del Casino, Alessio, Dunn, James F., Randle, Laura E., Dempster, Nicola M., Nahar, Lutfun, Sarker, Satyajit D., Cantú Reinhard, Fabián G., de Visser, Sam P., Dascombe, Mike J., Ismail, Fyaz M. D.

“…Antimalarials can interact with heme covalently, by π⋅⋅⋅π interactions or by hydrogen bonding. Consequently, the prototropy of 4‐aminoquinolines and quinoline…”
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Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice by Goldring, Christopher E. P., Kitteringham, Neil R., Elsby, Robert, Randle, Laura E., Clement, Yuri N., Williams, Dominic P., McMahon, Michael, Hayes, John D., Itoh, Ken, Yamamoto, Masayuki, Park, B. Kevin

“…The transcription factor NF‐E2‐related factor 2 (Nrf2) plays an essential role in the mammalian response to chemical and oxidative stress through induction of…”
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Isoquine and Related Amodiaquine Analogues:  A New Generation of Improved 4-Aminoquinoline Antimalarials by O'Neill, Paul M, Mukhtar, Amira, Stocks, Paul A, Randle, Laura E, Hindley, Stephen, Ward, Stephen A, Storr, Richard C, Bickley, Jamie F, O'Neil, Ian A, Maggs, James L, Hughes, Ruth H, Winstanley, Peter A, Bray, Patrick G, Park, B. Kevin

“…Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial that can cause adverse side effects including agranulocytosis and liver damage. The observed drug…”
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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice by Randle, Laura E, Goldring, Chris E.P, Benson, Craig A, Metcalfe, Peter N, Kitteringham, Neil R, Park, B. Kevin, Williams, Dominic P

“…Abstract The Keap1-Nrf2-ARE signalling pathway has emerged as an important regulator of the mammalian defence system to enable detoxification and clearance of…”
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Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes by Goldring, Chris E P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A, Randle, Laura E, Abdullah, Azman, Owen, Andrew, Liu, Xiaoping, Butler, Philip J, Williams, Dominic P, Metcalfe, Peter, Berens, Christian, Hillen, Wolfgang, Foster, Brian, Simpson, Alec, McLellan, Lesley, Park, B Kevin

“…Precise control of the level of protein expression in cells can yield quantitative and temporal information on the role of a given gene in normal cellular…”
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Modelling the impact of changes in the extracellular environment on the cytosolic free NAD.sup.+/NADH ratio during cell culture by Kelly, Ross A, Leedale, Joseph, Harrell, Andy, Beard, Daniel A, Randle, Laura E, Chadwick, Amy E, Webb, Steven D

“…Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in…”
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Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials by Casino, Alessio del, Lukinović, Valentina, Bhatt, Rakesh, Randle, Laura E., Dascombe, Michael J., Fennell, Dr Brian J., Drew, Michael G. B., Bell, Angus, Fielding, Alistair J., Ismail, Fyaz M. D.

“…A series of novel, homologous compounds possessing the general formula N1‐Nn‐bis(2,6‐dinitro‐4‐trifluormethylphenyl)‐1,n‐diamino alkanes (where n=4, 6, 10 or…”
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The Hepatotoxic Metabolite of Acetaminophen Directly Activates the Keapl-Nrf2 Cell Defense System by COPPLE, Ian M, GOLDRING, Christopher E, JENKINS, Rosalind E, CHIA, Alvin J. L, RANDLE, Laura E, HAYES, John D, KITTERINGHAM, Neil R, PARK, B. Kevin

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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keapl defence response pathway in CD-1 mice by RANDLE, Laura E, GOLDRING, Chris E. P, BENSON, Craig A, METCALFE, Peter N, KITTERINGHAM, Neil R, PARK, B. Kevin, WILLIAMS, Dominic P

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Activation of hepatic Nrf2 in viva by acetaminophen in CD-1 mice by GOLDRING, Christopher E. P, KITTERINGHAM, Neil R, PARK, B. Kevin, ELSBY, Robert, RANDLE, Laura E, CLEMENT, Yuri N, WILLLIANS, Dominic P, MCMAHON, Michael, HAYES, John D, ITOH, Ken, YAMAMOTO, Masayuki

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