Search Results - "Randjelovic, Pavle J."
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Toxic essential oils, part VI: Acute oral toxicity of lemon balm (Melissa officinalis L.) essential oil in BALB/c mice
Published in Food and chemical toxicology (01-11-2019)“…Despite being renowned for its volatiles, the data on the toxicity of the essential oil of lemon balm (Melissa officinalis L., Lamiaceae) is rather limited…”
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The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent – is the citronellal the activity carrier?
Published in Journal of ethnopharmacology (05-10-2023)“…Among the fewest drugs discovered are those belonging to the class of anxiolytics. Although some drug targets for anxiety disorders are established, it is hard…”
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Spasmolytic, antimicrobial and cytotoxic activities of 5-phenylpentyl isothiocyanate, a new glucosinolate autolysis product from horseradish (Armoracia rusticana P. Gaertn., B. Mey. & Scherb., Brassicaceae)
Published in Food chemistry (01-10-2017)“…•A new natural product 5-phenylpentyl isothiocyanate (PhPeITC) was found in horseradish.•The first direct proof of the existence of a 5-phenylpentyl…”
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Lemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies
Published in Journal of ethnopharmacology (10-02-2022)“…Besides psyche-related symptoms, patients with anxiety disorders can have a large number of somatic symptoms as well. Although the treatment of these disorders…”
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How do different bile acid derivatives affect rat macrophage function – Friends or foes?
Published in Chemico-biological interactions (25-09-2023)“…Due to an increased need for new immunomodulatory agents, many previously known molecules have been structurally modified in order to obtain new drugs,…”
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Linking the antimicrobial and anti-inflammatory effects of immortelle essential oil with its chemical composition – The interplay between the major and minor constituents
Published in Food and chemical toxicology (01-12-2021)“…Immortelle (Helichrysum italicum, Asteraceae) essential oil has been widely used in alternative medicine to accelerate wound healing, as well as in cosmetic…”
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Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L
Published in Food and chemical toxicology (01-07-2017)“…Neurotoxic thujones (α- and β-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine…”
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Two goitrogenic 1,3-oxazolidine-2-thione derivatives from Brassicales taxa: Challenging identification, occurrence and immunomodulatory effects
Published in Food and chemical toxicology (01-12-2017)“…1,3-Oxazolidine-2-thione derivatives are glucosinolate-related food constituents known to impart (thyreo)toxic properties to some cruciferous vegetables. In…”
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Toxic essential oils. Part II: Chemical, toxicological, pharmacological and microbiological profiles of Artemisia annua L. volatiles
Published in Food and chemical toxicology (01-08-2013)“…[Display omitted] •Artemisia annua L., important in the treatment of malaria, is a rich source of both artemisinin and essential oil.•Chemical and…”
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Prenylated β-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites
Published in Food and chemical toxicology (01-08-2018)“…Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant…”
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Marrubiin Inhibits Peritoneal Inflammatory Response Induced by Carrageenan Application in C57 Mice
Published in International journal of molecular sciences (19-04-2024)“…Marrubiin is a diterpene with a long history of a wide range of biological activities. In this study, the anti-inflammatory effects of marrubiin were…”
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Distribution of methyl and isopropyl N-methylanthranilates and their metabolites in organs of rats treated with these two essential-oil constituents
Published in Food and chemical toxicology (01-06-2019)“…Two volatile alkaloids, methyl (MMA) and isopropyl N-methylanthranilates (IMA), identified in the essential oil of Choisya ternata Kunth (Rutaceae), have been…”
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Effects of Methyl and Isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on Experimental Anxiety and Depression in Mice
Published in Phytotherapy research (01-09-2013)“…Choisya ternata Kunth (Rutaceae) is a plant species used in Mexican folk medicine for its antispasmodic and simulative properties. Recently, we identified a…”
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Melatonin treatment prevents carbon-tetrachloride induced rat brain injury
Published in Toxicology research (Cambridge) (01-10-2023)“…Abstract Introduction Herein the neuroprotective properties of melatonin, a highly effective antioxidant, administered in a single dose 50 mg/kg…”
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Distinct urinary metabolite profiles of two pharmacologically active N-methylanthranilates: Three approaches to xenobiotic metabolite identification
Published in Food and chemical toxicology (01-11-2017)“…Two volatile alkaloids, isopropyl N-methylanthranilate (IMA) and methyl N-methylanthranilate (MMA), present in the human diet and cosmetic products, were…”
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Methyl and Isopropyl N‐Methylanthranilates Affect Primary Macrophage Function – An Insight into the Possible Immunomodulatory Mode of Action
Published in Chemistry & biodiversity (01-01-2022)“…To complement the knowledge on the anti‐inflammatory activity of methyl and isopropyl N‐methylanthranilates, two natural products with panacea‐like properties,…”
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Choosing the Right Essential Oil for a Mouthwash: Chemical, Antimicrobial and Cytotoxic Studies
Published in Chemistry & biodiversity (01-11-2020)“…Thirteen commercial essential oils were assessed for their possible inclusion in a mouthwash formulation based on their inhibitory effect against potentially…”
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An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters
Published in Oxidative medicine and cellular longevity (2021)“…Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that…”
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Anxiolytic‐Like Action of Selected 4‐(Alkylamino)‐3‐nitrocoumarin Derivatives in BALB/c Mice
Published in Chemistry & biodiversity (01-06-2020)“…In this work, we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens,…”
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Prevalence of self-medication practice with herbal products among non-psychotic psychiatric patients from southeastern Serbia: A cross-sectional study
Published in Saudi pharmaceutical journal (01-09-2017)“…The aim of this study was to evaluate the usage prevalence of herbal products (HP) and to ascertain the identity, mode and adverse effects of plant taxa used…”
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