Search Results - "Randis, Tara M"

Role of Pore-Forming Toxins in Bacterial Infectious Diseases by Los, Ferdinand C O, Randis, Tara M, Aroian, Raffi V, Ratner, Adam J

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Group B Streptococcus Drives Major Transcriptomic Changes in the Colonic Epithelium by Domínguez, Kristen, Lindon, April K, Gibbons, Justin, Darch, Sophie E, Randis, Tara M

“…Group B Streptococcus (GBS) is a leading cause of infant sepsis worldwide. Colonization of the gastrointestinal tract is a critical precursor to late-onset…”
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Vaginal carriage of Haemophilus influenzae in a non-pregnant reproductive-age population by Limaye, Meghana A, Brubaker, Sara, Randis, Tara M, Ratner, Adam J

“…Haemophilus influenzae (Hi) is an emerging cause of early onset neonatal sepsis, but mechanisms of transmission are not well understood. We aimed to determine…”
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Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy by Kuperwaser, Felicia, Avital, Gal, Vaz, Michelle J, Noble, Kristen N, Dammann, Allison N, Randis, Tara M, Aronoff, David M, Ratner, Adam J, Yanai, Itai

“…Group B Streptococcus (GBS) is a pathobiont that can ascend to the placenta and cause adverse pregnancy outcomes, in part through production of the toxin…”
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Chorioamnionitis: time for a new approach by Randis, Tara M, Polin, Richard A, Saade, George

“…The association between maternal chorioamnionitis and early-onset sepsis in the newborn has long been recognized, and established guidelines recommend treating…”
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Inerolysin, a Cholesterol-Dependent Cytolysin Produced by Lactobacillus iners by RAMPERSAUD, Ryan, PLANET, Paul J, RANDIS, Tara M, KULKARNI, Ritwij, AGUILAR, Jorge L, LEHRER, Robert I, RATNER, Adam J

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Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis by Hensel, Katherine J., MPH, Randis, Tara M., MD, Gelber, Shari E., MD, PhD, Ratner, Adam J., MD, MPH

“…Objective Recent data suggest vitamin D deficiency (VDD) is associated with bacterial vaginosis (BV) during pregnancy. We hypothesized that VDD is a risk…”
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Systematic Review of Literature Examining Bacterial Urinary Tract Infections in Diabetes by Paudel, Santosh, John, Preeti P., Poorbaghi, Seyedeh Leila, Randis, Tara M., Kulkarni, Ritwij

“…This systematic review addresses the central research question, “what is known from the published, peer-reviewed literature about the impact of diabetes on the…”
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Role of PI3Kδ and PI3Kγ in inflammatory arthritis and tissue localization of neutrophils by Randis, Tara M, Puri, Kamal D, Zhou, Hairu, Diacovo, Thomas G

“…The p110δ isoform of class I phosphoinositide 3-kinase (PI3K) plays a major role in B cell receptor signaling, while its p110γ counterpart is thought to…”
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High prevalence of Group B Streptococcus colonization among pregnant women in Amman, Jordan by Clouse, Kate, Shehabi, Asem, Suleimat, Abel Mani, Faouri, Samir, Khuri-Bulos, Najwa, Al Jammal, Abeer, Chappell, James, Fortner, Kimberly B, Chamby, Anna B, Randis, Tara M, Ratner, Adam J, Aronoff, David M, Halasa, Natasha

“…Little is known of the burden of Group B Streptococcus (GBS) colonization among pregnant women in Jordan. We conducted a pilot study to determine the…”
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Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes by LaRocca, Timothy J, Stivison, Elizabeth A, Hod, Eldad A, Spitalnik, Steven L, Cowan, Peter J, Randis, Tara M, Ratner, Adam J

“…A subgroup of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for…”
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Cigarette Smoke Inhibits Airway Epithelial Cell Innate Immune Responses to Bacteria by Kulkarni, Ritwij, Rampersaud, Ryan, Aguilar, Jorge L, Randis, Tara M, Kreindler, James L, Ratner, Adam J

“…The human upper respiratory tract, including the nasopharynx, is colonized by a diverse array of microorganisms. While the host generally exists in harmony…”
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Vaginolysin Drives Epithelial Ultrastructural Responses to Gardnerella vaginalis by Randis, Tara M, Zaklama, Joanne, LaRocca, Timothy J, Los, Ferdinand C O, Lewis, Emma L, Desai, Purnahamsi, Rampersaud, Ryan, Amaral, Fábio E, Ratner, Adam J

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β-Hemolysin/cytolysin of Group B Streptococcus enhances host inflammation but is dispensable for establishment of urinary tract infection by Kulkarni, Ritwij, Randis, Tara M, Antala, Swati, Wang, Alice, Amaral, Fábio E, Ratner, Adam J

“…Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionately affects neonates and women in the peripartum period and…”
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Rational manipulation of mRNA folding free energy allows rheostat control of pneumolysin production by Streptococcus pneumoniae by Amaral, Fábio E, Parker, Dane, Randis, Tara M, Kulkarni, Ritwij, Prince, Alice S, Shirasu-Hiza, Mimi M, Ratner, Adam J

“…The contribution of specific factors to bacterial virulence is generally investigated through creation of genetic "knockouts" that are then compared to…”
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What's new in the management of neonatal early-onset sepsis? by Fleiss, Noa, Schwabenbauer, Kathleen, Randis, Tara M, Polin, Richard A

“…The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and…”
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Gardnerella and Prevotella: Co-conspirators in the Pathogenesis of Bacterial Vaginosis by Randis, Tara M, Ratner, Adam J

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Antibody-based detection and inhibition of vaginolysin, the Gardnerella vaginalis cytolysin by Randis, Tara M, Kulkarni, Ritwij, Aguilar, Jorge L, Ratner, Adam J

“…Bacterial vaginosis (BV) is the most common vaginal infection worldwide and is associated with significant adverse sequelae. We have recently characterized…”
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Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores by Aguilar, Jorge L, Kulkarni, Ritwij, Randis, Tara M, Soman, Sandeep, Kikuchi, Alexander, Yin, Yuxin, Ratner, Adam J

“…Diverse bacterial species produce pore-forming toxins (PFT) that can puncture eukaryotic cell membranes. Host cells respond to sublytic concentrations of PFT…”
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Hyponatremic Seizures and Adrenal Hypoplasia Congenita in a Neonate with Congenital Diaphragmatic Hernia by Mally, Pradeep V., Pappas, John G., Breidbart, Emily, Purrier, Sheryl, Verma, Sourabh, Randis, Tara M.

“…Congenital diaphragmatic hernia (CDH) in neonates may occur as an isolated finding, in association with other anomalies, or as part of a genetic syndrome. We…”
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